ENSG00000146802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312814 ENSG00000146802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM168 protein_coding protein_coding 7.291872 1.395446 12.07337 0.20613 0.3162029 3.103923 2.0935162 0.87124148 3.1115803 0.20339997 0.21986827 1.8246673 0.36535417 0.6580333 0.25733333 -0.4007000 3.547367e-01 7.545499e-09 FALSE TRUE
ENST00000418785 ENSG00000146802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM168 protein_coding protein_coding 7.291872 1.395446 12.07337 0.20613 0.3162029 3.103923 0.4768867 0.19463794 0.2878577 0.12913677 0.15810107 0.5415498 0.07552500 0.1585000 0.02453333 -0.1339667 6.719685e-01 7.545499e-09 FALSE TRUE
ENST00000447395 ENSG00000146802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM168 protein_coding protein_coding 7.291872 1.395446 12.07337 0.20613 0.3162029 3.103923 0.3913910 0.25197006 0.1728468 0.25197006 0.17284682 -0.5187665 0.12461667 0.1402667 0.01480000 -0.1254667 7.447175e-01 7.545499e-09 FALSE TRUE
ENST00000454074 ENSG00000146802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM168 protein_coding protein_coding 7.291872 1.395446 12.07337 0.20613 0.3162029 3.103923 3.2144310 0.07759629 5.8552924 0.07759629 0.18393054 6.0651894 0.33007917 0.0432000 0.48500000 0.4418000 3.412272e-03 7.545499e-09 FALSE TRUE
MSTRG.30529.6 ENSG00000146802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM168 protein_coding   7.291872 1.395446 12.07337 0.20613 0.3162029 3.103923 0.9253907 0.00000000 2.2861153 0.00000000 0.02293797 7.8430513 0.07537917 0.0000000 0.18963333 0.1896333 7.545499e-09 7.545499e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146802 E001 211.945713 0.0031588781 6.135591e-15 2.085341e-13 7 112762377 112767084 4708 - 2.146 2.425 0.930
ENSG00000146802 E002 30.645100 0.0006901277 1.236205e-01 2.251142e-01 7 112767085 112767135 51 - 1.352 1.493 0.487
ENSG00000146802 E003 29.867153 0.0006781763 2.765592e-01 4.160171e-01 7 112767136 112767174 39 - 1.350 1.459 0.377
ENSG00000146802 E004 53.693245 0.0004675970 2.446873e-01 3.796776e-01 7 112767175 112767373 199 - 1.601 1.693 0.315
ENSG00000146802 E005 58.192487 0.0005083246 6.151175e-02 1.291773e-01 7 112767374 112767540 167 - 1.629 1.758 0.438
ENSG00000146802 E006 66.915041 0.0035119639 1.975789e-01 3.231858e-01 7 112767541 112767744 204 - 1.692 1.792 0.337
ENSG00000146802 E007 31.491478 0.0006898751 5.226355e-01 6.564088e-01 7 112772781 112772801 21 - 1.396 1.365 -0.107
ENSG00000146802 E008 28.771379 0.0007004988 4.469932e-01 5.884216e-01 7 112772802 112772818 17 - 1.362 1.318 -0.153
ENSG00000146802 E009 46.987711 0.0005228691 9.177601e-01 9.520081e-01 7 112772819 112772945 127 - 1.558 1.574 0.054
ENSG00000146802 E010 39.479638 0.0005605199 5.649551e-01 6.921533e-01 7 112772946 112773014 69 - 1.490 1.470 -0.068
ENSG00000146802 E011 37.507642 0.0006018621 1.718609e-01 2.906363e-01 7 112773015 112773055 41 - 1.479 1.394 -0.292
ENSG00000146802 E012 53.197364 0.0006147940 2.630467e-01 4.009112e-01 7 112775176 112775318 143 - 1.623 1.573 -0.170
ENSG00000146802 E013 1.526201 0.0609399556 6.869415e-01 7.893671e-01 7 112778223 112778656 434 - 0.343 0.254 -0.601
ENSG00000146802 E014 36.888338 0.0006077211 6.089493e-01 7.285356e-01 7 112783698 112783756 59 - 1.463 1.446 -0.058
ENSG00000146802 E015 29.587474 0.0007158208 3.671367e-01 5.115241e-01 7 112783757 112783783 27 - 1.375 1.318 -0.196
ENSG00000146802 E016 79.304329 0.0003860935 2.031934e-01 3.302225e-01 7 112783784 112784094 311 - 1.791 1.746 -0.152
ENSG00000146802 E017 111.604118 0.0002812251 7.670123e-07 6.532760e-06 7 112784095 112784724 630 - 1.959 1.740 -0.738
ENSG00000146802 E018 36.482416 0.0121229309 2.470774e-03 8.676033e-03 7 112784725 112784821 97 - 1.492 1.184 -1.075
ENSG00000146802 E019 25.595624 0.0007816024 4.521096e-04 1.975114e-03 7 112784822 112784854 33 - 1.350 0.988 -1.293
ENSG00000146802 E020 38.175740 0.0005522636 1.096621e-06 9.025150e-06 7 112784855 112784953 99 - 1.523 1.083 -1.542
ENSG00000146802 E021 2.825747 0.0073288064 2.635603e-02 6.465783e-02 7 112788454 112788544 91 - 0.549 0.001 -10.340
ENSG00000146802 E022 39.904689 0.0005404801 7.898933e-08 8.184365e-07 7 112790160 112790423 264 - 1.545 1.053 -1.725