ENSG00000146776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318724 ENSG00000146776 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L1 protein_coding protein_coding 3.759693 3.325454 4.466106 0.2265189 0.4794031 0.4243608 0.5884662 0.6171833 0.8160780 0.09512273 0.08084965 0.3973908 0.16065000 0.18410000 0.18966667 0.005566667 1.00000000 0.02989757 FALSE FALSE
ENST00000419735 ENSG00000146776 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L1 protein_coding protein_coding 3.759693 3.325454 4.466106 0.2265189 0.4794031 0.4243608 1.0123848 0.8579458 1.1201912 0.07124658 0.04304845 0.3808900 0.27393333 0.26293333 0.25803333 -0.004900000 1.00000000 0.02989757 FALSE TRUE
ENST00000464874 ENSG00000146776 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L1 protein_coding processed_transcript 3.759693 3.325454 4.466106 0.2265189 0.4794031 0.4243608 0.8049556 0.6132975 0.9502352 0.05851909 0.58859592 0.6234669 0.20435000 0.18386667 0.19136667 0.007500000 0.93338096 0.02989757 FALSE FALSE
MSTRG.30471.14 ENSG00000146776 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L1 protein_coding   3.759693 3.325454 4.466106 0.2265189 0.4794031 0.4243608 0.5397024 0.8451607 0.3826738 0.22209723 0.05708212 -1.1228644 0.14739167 0.24786667 0.08963333 -0.158233333 0.02989757 0.02989757 FALSE TRUE
MSTRG.30471.3 ENSG00000146776 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L1 protein_coding   3.759693 3.325454 4.466106 0.2265189 0.4794031 0.4243608 0.3050126 0.1822171 0.6652242 0.06570438 0.04487996 1.8126296 0.07589167 0.05776667 0.15016667 0.092400000 0.06552699 0.02989757 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146776 E001 102.5627541 0.0008648454 8.454029e-05 0.0004495440 7 105604772 105607770 2999 - 1.953 2.068 0.388
ENSG00000146776 E002 0.1482932 0.0413296966 3.813071e-01   7 105607771 105607780 10 - 0.000 0.136 11.480
ENSG00000146776 E003 0.1482932 0.0413296966 3.813071e-01   7 105607781 105607783 3 - 0.000 0.136 11.480
ENSG00000146776 E004 0.2934659 0.0289320271 8.504688e-01   7 105607784 105607786 3 - 0.110 0.136 0.352
ENSG00000146776 E005 9.3175615 0.0019121334 2.134458e-01 0.3425906423 7 105607787 105607890 104 - 0.943 1.067 0.458
ENSG00000146776 E006 6.2366903 0.0027065665 6.217010e-01 0.7386511122 7 105607891 105607893 3 - 0.882 0.814 -0.261
ENSG00000146776 E007 10.5698782 0.0017247406 8.537500e-01 0.9095019341 7 105610529 105610603 75 - 1.055 1.067 0.043
ENSG00000146776 E008 2.8814388 0.3683910999 9.509490e-01 0.9733184388 7 105613474 105613732 259 - 0.554 0.645 0.402
ENSG00000146776 E009 2.0240693 0.0072906838 1.101371e-01 0.2057320608 7 105613733 105613861 129 - 0.333 0.596 1.355
ENSG00000146776 E010 16.1487740 0.0013959944 9.319064e-01 0.9610913935 7 105613862 105614137 276 - 1.226 1.226 0.001
ENSG00000146776 E011 30.5515492 0.0008021709 1.055078e-04 0.0005473952 7 105614138 105614816 679 - 1.604 1.356 -0.851
ENSG00000146776 E012 1.1112941 0.0766950396 9.729857e-01 0.9871325146 7 105617792 105618097 306 - 0.333 0.322 -0.066
ENSG00000146776 E013 4.1128635 0.0074637573 6.123022e-01 0.7312489955 7 105620200 105620232 33 - 0.748 0.670 -0.324
ENSG00000146776 E014 6.1810669 0.0029184563 6.325713e-01 0.7473945534 7 105620233 105620321 89 - 0.830 0.882 0.203
ENSG00000146776 E015 14.9652965 0.0121989478 5.117749e-01 0.6467291974 7 105624075 105624267 193 - 1.171 1.227 0.201
ENSG00000146776 E016 6.3546067 0.0029710856 6.564390e-01 0.7660065784 7 105638353 105638368 16 - 0.898 0.838 -0.231
ENSG00000146776 E017 16.3233776 0.0012133245 4.801811e-02 0.1056643677 7 105638369 105638609 241 - 1.313 1.142 -0.604
ENSG00000146776 E018 9.9116404 0.0054967444 1.889970e-02 0.0491151061 7 105639487 105639569 83 - 1.145 0.882 -0.968
ENSG00000146776 E019 16.9211059 0.0448942986 6.334784e-02 0.1322751391 7 105642838 105643121 284 - 1.348 1.104 -0.863
ENSG00000146776 E020 0.4418608 0.0259997192 1.337245e-01 0.2393330006 7 105649407 105649560 154 - 0.270 0.000 -13.114
ENSG00000146776 E021 14.6529649 0.0423374589 1.368486e-02 0.0375042427 7 105665066 105665288 223 - 1.319 0.997 -1.151
ENSG00000146776 E022 0.0000000       7 105677946 105678023 78 -      
ENSG00000146776 E023 0.1515154 0.0427209975 6.212089e-01   7 105679052 105679206 155 - 0.110 0.000 -11.544
ENSG00000146776 E024 0.0000000       7 105691560 105691637 78 -      
ENSG00000146776 E025 3.6620215 0.0042393581 6.185162e-02 0.1297357497 7 105760373 105760553 181 - 0.791 0.506 -1.231
ENSG00000146776 E026 20.9793598 0.0011509222 4.810584e-01 0.6193050692 7 105760554 105761463 910 - 1.325 1.370 0.155
ENSG00000146776 E027 3.8383204 0.0052569620 1.305872e-02 0.0360484755 7 105779985 105780154 170 - 0.479 0.838 1.546
ENSG00000146776 E028 0.0000000       7 105788123 105788603 481 -      
ENSG00000146776 E029 20.7576860 0.0088900646 4.326627e-01 0.5751117127 7 105788604 105788708 105 - 1.313 1.374 0.212
ENSG00000146776 E030 3.5594556 0.1129539848 7.614548e-01 0.8453236757 7 105875091 105875234 144 - 0.648 0.671 0.099
ENSG00000146776 E031 21.2034319 0.0011444044 1.840821e-01 0.3063539700 7 105875812 105875880 69 - 1.307 1.396 0.310
ENSG00000146776 E032 20.9413049 0.0014673895 6.587572e-01 0.7677752685 7 105876378 105876599 222 - 1.337 1.363 0.090