ENSG00000146733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275605 ENSG00000146733 HEK293_OSMI2_2hA HEK293_TMG_2hB PSPH protein_coding protein_coding 24.50871 21.61506 27.85815 3.13841 0.3877229 0.365913 1.942506 2.6660016 2.165529 0.2808492 0.2116561 -0.29871299 0.08475833 0.12480000 0.07763333 -0.04716667 0.02848818 0.00471569 FALSE TRUE
ENST00000395471 ENSG00000146733 HEK293_OSMI2_2hA HEK293_TMG_2hB PSPH protein_coding protein_coding 24.50871 21.61506 27.85815 3.13841 0.3877229 0.365913 9.549391 10.8414857 10.698583 1.5029018 0.5563305 -0.01912494 0.40454583 0.50290000 0.38396667 -0.11893333 0.00471569 0.00471569 FALSE TRUE
ENST00000421626 ENSG00000146733 HEK293_OSMI2_2hA HEK293_TMG_2hB PSPH protein_coding protein_coding 24.50871 21.61506 27.85815 3.13841 0.3877229 0.365913 3.636559 1.5561785 4.948103 0.1187966 1.1354352 1.66253951 0.13832083 0.07623333 0.17740000 0.10116667 0.12181204 0.00471569 FALSE FALSE
MSTRG.29907.1 ENSG00000146733 HEK293_OSMI2_2hA HEK293_TMG_2hB PSPH protein_coding   24.50871 21.61506 27.85815 3.13841 0.3877229 0.365913 1.634485 0.9712201 2.490239 0.4151540 0.7086948 1.34941741 0.05835417 0.04136667 0.08980000 0.04843333 0.38235806 0.00471569 TRUE TRUE
MSTRG.29907.19 ENSG00000146733 HEK293_OSMI2_2hA HEK293_TMG_2hB PSPH protein_coding   24.50871 21.61506 27.85815 3.13841 0.3877229 0.365913 2.610377 1.3455263 1.841154 0.7041027 1.2027536 0.44957171 0.09584167 0.05533333 0.06643333 0.01110000 1.00000000 0.00471569 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146733 E001 50.4284427 0.0041310700 1.424571e-02 3.878488e-02 7 56010966 56011044 79 - 1.786 1.655 -0.442
ENSG00000146733 E002 28.3965811 0.0092245171 3.792849e-02 8.721462e-02 7 56011045 56011050 6 - 1.554 1.401 -0.526
ENSG00000146733 E003 32.8344235 0.0205489872 5.041088e-02 1.098986e-01 7 56011051 56011063 13 - 1.616 1.460 -0.535
ENSG00000146733 E004 28.0652330 0.0154197084 1.719066e-01 2.906839e-01 7 56011064 56011065 2 - 1.525 1.423 -0.350
ENSG00000146733 E005 27.8114062 0.0166996104 2.489596e-01 3.847035e-01 7 56011066 56011067 2 - 1.512 1.428 -0.289
ENSG00000146733 E006 36.4860982 0.0041109801 5.852105e-01 7.089676e-01 7 56011068 56011116 49 - 1.598 1.574 -0.082
ENSG00000146733 E007 50.5879878 0.0061253768 2.724143e-01 4.112915e-01 7 56011117 56011134 18 - 1.679 1.755 0.257
ENSG00000146733 E008 94.7252617 0.0020257969 4.764507e-02 1.049914e-01 7 56011135 56011233 99 - 1.940 2.027 0.292
ENSG00000146733 E009 147.3489466 0.0003724831 1.801058e-07 1.741731e-06 7 56011234 56011420 187 - 2.084 2.245 0.539
ENSG00000146733 E010 50.8609051 0.0222374160 4.211173e-01 5.642507e-01 7 56011421 56011425 5 - 1.676 1.748 0.246
ENSG00000146733 E011 99.8974122 0.0226187628 3.655312e-03 1.217026e-02 7 56011426 56011499 74 - 1.867 2.094 0.765
ENSG00000146733 E012 69.7046416 0.0072491087 7.499095e-06 5.125297e-05 7 56011500 56011501 2 - 1.687 1.960 0.918
ENSG00000146733 E013 95.8430625 0.0036604995 7.448481e-10 1.131862e-08 7 56011502 56011537 36 - 1.810 2.103 0.983
ENSG00000146733 E014 46.6724992 0.0067557474 7.729758e-06 5.268420e-05 7 56011538 56011540 3 - 1.498 1.801 1.028
ENSG00000146733 E015 45.5404942 0.0083801941 1.866803e-04 9.065424e-04 7 56011541 56011543 3 - 1.516 1.774 0.878
ENSG00000146733 E016 255.8652800 0.0002356243 6.029526e-08 6.389638e-07 7 56011544 56011869 326 - 2.345 2.471 0.420
ENSG00000146733 E017 84.4302457 0.0042919322 1.393128e-01 2.471129e-01 7 56015023 56015030 8 - 1.894 1.964 0.236
ENSG00000146733 E018 217.2370836 0.0003848628 9.004359e-01 9.404886e-01 7 56015031 56015171 141 - 2.345 2.347 0.007
ENSG00000146733 E019 133.5711184 0.0002462940 2.543982e-02 6.278902e-02 7 56017234 56017276 43 - 2.170 2.108 -0.205
ENSG00000146733 E020 189.7706030 0.0002405588 6.603359e-03 2.019500e-02 7 56017277 56017379 103 - 2.321 2.258 -0.212
ENSG00000146733 E021 198.9095018 0.0002698390 3.885324e-02 8.891152e-02 7 56019600 56019734 135 - 2.331 2.284 -0.157
ENSG00000146733 E022 0.4482035 0.0311653669 8.865527e-02 1.730707e-01 7 56019735 56019808 74 - 0.295 0.000 -10.973
ENSG00000146733 E023 207.3349110 0.0001979245 8.208104e-03 2.431094e-02 7 56021073 56021180 108 - 2.355 2.297 -0.196
ENSG00000146733 E024 141.4242466 0.0002744231 8.767650e-02 1.716003e-01 7 56021181 56021205 25 - 2.185 2.140 -0.149
ENSG00000146733 E025 130.0435373 0.0004829554 3.286512e-02 7.753768e-02 7 56021206 56021231 26 - 2.156 2.093 -0.210
ENSG00000146733 E026 127.5639073 0.0002665178 1.990013e-01 3.249681e-01 7 56031929 56031977 49 - 2.134 2.099 -0.115
ENSG00000146733 E027 117.0278743 0.0013154142 5.752771e-01 7.009237e-01 7 56031978 56032054 77 - 2.086 2.068 -0.060
ENSG00000146733 E028 1.5543008 0.0088182060 5.128217e-02 1.114377e-01 7 56032217 56032281 65 - 0.556 0.218 -1.994
ENSG00000146733 E029 0.8793535 0.1088311910 4.341861e-01 5.765743e-01 7 56033134 56033380 247 - 0.361 0.216 -1.009
ENSG00000146733 E030 20.1316130 0.0127345675 7.227635e-01 8.168247e-01 7 56033381 56033494 114 - 1.344 1.311 -0.115
ENSG00000146733 E031 130.6168759 0.0004286172 3.295136e-03 1.113585e-02 7 56033961 56034103 143 - 2.169 2.081 -0.293
ENSG00000146733 E032 56.1086542 0.0007057522 4.640370e-02 1.027643e-01 7 56034104 56034106 3 - 1.808 1.720 -0.299
ENSG00000146733 E033 66.8339519 0.0003981874 1.113379e-02 3.148717e-02 7 56034107 56034147 41 - 1.888 1.785 -0.348
ENSG00000146733 E034 46.7939299 0.0011256072 2.418398e-04 1.141059e-03 7 56034148 56034154 7 - 1.772 1.582 -0.645
ENSG00000146733 E035 11.7879143 0.0311756454 1.214343e-01 2.219737e-01 7 56034155 56034172 18 - 1.202 0.994 -0.751
ENSG00000146733 E036 35.7735928 0.0194792263 1.783403e-01 2.990577e-01 7 56042391 56042643 253 - 1.503 1.606 0.351
ENSG00000146733 E037 12.2257461 0.0021274295 7.925493e-01 8.673500e-01 7 56043148 56043261 114 - 1.136 1.116 -0.071
ENSG00000146733 E038 132.9448940 0.0111033592 2.808975e-02 6.818876e-02 7 56051138 56051313 176 - 2.199 2.053 -0.489
ENSG00000146733 E039 94.1120278 0.0126868555 1.009511e-02 2.899598e-02 7 56051314 56051604 291 - 2.068 1.883 -0.620