ENSG00000146592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000478078 ENSG00000146592 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB5 protein_coding retained_intron 9.454599 13.21313 4.796289 0.8722413 0.4013693 -1.460068 6.0523040 9.69130199 1.6477104 0.60721939 0.25909208 -2.548986 0.58459583 0.7345 0.3391333 -0.3953667 2.461483e-10 8.326519e-20 FALSE FALSE
ENST00000482692 ENSG00000146592 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB5 protein_coding processed_transcript 9.454599 13.21313 4.796289 0.8722413 0.4013693 -1.460068 0.6689216 1.14980132 0.1846382 0.25588217 0.09596888 -2.575011 0.06128333 0.0864 0.0422000 -0.0442000 5.308912e-01 8.326519e-20   TRUE
MSTRG.29630.2 ENSG00000146592 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB5 protein_coding   9.454599 13.21313 4.796289 0.8722413 0.4013693 -1.460068 1.2502090 0.63297571 1.8551068 0.07721065 0.16522129 1.536422 0.18831667 0.0482 0.3891000 0.3409000 8.326519e-20 8.326519e-20 FALSE TRUE
MSTRG.29630.4 ENSG00000146592 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB5 protein_coding   9.454599 13.21313 4.796289 0.8722413 0.4013693 -1.460068 0.1944364 0.05325687 0.3265886 0.05325687 0.14868143 2.411692 0.02713333 0.0037 0.0650000 0.0613000 2.321803e-02 8.326519e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146592 E001 0.0000000       7 28299321 28299441 121 +      
ENSG00000146592 E002 0.2214452 0.0371772973 6.325435e-01   7 28409254 28409278 25 + 0.000 0.099 9.049
ENSG00000146592 E003 0.5911836 0.0233667852 1.393218e-01 2.471195e-01 7 28409279 28409297 19 + 0.000 0.248 12.617
ENSG00000146592 E004 0.7728880 0.0162529273 6.963712e-02 1.427533e-01 7 28409298 28409305 8 + 0.000 0.307 13.048
ENSG00000146592 E005 1.5855168 0.0660750823 8.810354e-03 2.580982e-02 7 28409306 28409334 29 + 0.000 0.489 13.725
ENSG00000146592 E006 3.0581407 0.0157072725 6.917355e-05 3.760430e-04 7 28409335 28409366 32 + 0.000 0.710 14.809
ENSG00000146592 E007 5.4637921 0.0708729528 8.463682e-02 1.668143e-01 7 28409367 28409375 9 + 0.590 0.848 1.067
ENSG00000146592 E008 33.3846107 0.0007976380 5.775336e-12 1.248710e-10 7 28409376 28409386 11 + 1.200 1.606 1.405
ENSG00000146592 E009 49.1521430 0.0014880263 7.270152e-17 3.180851e-15 7 28409387 28409423 37 + 1.343 1.771 1.462
ENSG00000146592 E010 9.3150559 0.0027289141 1.916118e-07 1.842841e-06 7 28409658 28409895 238 + 0.486 1.117 2.550
ENSG00000146592 E011 57.8453748 0.0019117507 2.037099e-30 3.530854e-28 7 28409896 28410014 119 + 1.233 1.868 2.177
ENSG00000146592 E012 139.8680639 0.0003812916 7.358000e-82 1.482927e-78 7 28410015 28410726 712 + 1.630 2.251 2.090
ENSG00000146592 E013 13.0271543 0.0037509501 1.172108e-06 9.594378e-06 7 28410727 28410770 44 + 0.743 1.223 1.792
ENSG00000146592 E014 1.7358017 0.0265454623 6.947786e-01 7.955258e-01 7 28412518 28412917 400 + 0.423 0.445 0.116
ENSG00000146592 E015 0.0000000       7 28435615 28435688 74 +      
ENSG00000146592 E016 7.9333349 0.0030021959 1.139893e-03 4.437010e-03 7 28488175 28488246 72 + 1.165 0.730 -1.641
ENSG00000146592 E017 0.0000000       7 28491130 28491263 134 +      
ENSG00000146592 E018 10.0284693 0.0017737935 4.078136e-04 1.804402e-03 7 28494906 28494999 94 + 1.253 0.823 -1.582
ENSG00000146592 E019 13.3195269 0.0161187547 7.933525e-03 2.361186e-02 7 28507616 28507737 122 + 1.335 0.976 -1.285
ENSG00000146592 E020 0.0000000       7 28513464 28513838 375 +      
ENSG00000146592 E021 10.5909853 0.0017859280 3.897743e-03 1.285722e-02 7 28570365 28570437 73 + 1.243 0.885 -1.305
ENSG00000146592 E022 15.2639010 0.0014062974 7.364919e-05 3.977031e-04 7 28570438 28570537 100 + 1.411 1.000 -1.461
ENSG00000146592 E023 0.0000000       7 28609061 28609120 60 +      
ENSG00000146592 E024 0.0000000       7 28685981 28686136 156 +      
ENSG00000146592 E025 0.7416549 0.0608947329 7.788402e-01 8.577354e-01 7 28686137 28686197 61 + 0.261 0.181 -0.672
ENSG00000146592 E026 15.6162391 0.0011274690 2.907678e-06 2.182106e-05 7 28718753 28718879 127 + 1.444 0.977 -1.661
ENSG00000146592 E027 10.0052776 0.0017737712 5.127202e-06 3.639734e-05 7 28724222 28724299 78 + 1.291 0.750 -2.005
ENSG00000146592 E028 7.3428919 0.0022729263 2.213128e-05 1.358137e-04 7 28724300 28724332 33 + 1.177 0.611 -2.185
ENSG00000146592 E029 0.1817044 0.0398475579 6.325464e-01   7 28724333 28724676 344 + 0.000 0.099 11.001
ENSG00000146592 E030 0.0000000       7 28726681 28726731 51 +      
ENSG00000146592 E031 1.1823723 0.0108249506 4.692654e-04 2.042478e-03 7 28749295 28749545 251 + 0.633 0.000 -15.794
ENSG00000146592 E032 0.0000000       7 28778945 28779228 284 +      
ENSG00000146592 E033 19.0584179 0.0065107143 1.755774e-10 2.971203e-09 7 28804199 28804522 324 + 1.581 0.953 -2.220
ENSG00000146592 E034 15.1529391 0.0013345922 1.108686e-07 1.117100e-06 7 28809187 28809408 222 + 1.457 0.927 -1.892
ENSG00000146592 E035 5.5438753 0.0682415147 8.334427e-02 1.648034e-01 7 28809409 28809414 6 + 1.002 0.637 -1.440
ENSG00000146592 E036 11.4410332 0.0396572737 1.305704e-03 4.995895e-03 7 28818071 28818179 109 + 1.334 0.839 -1.804
ENSG00000146592 E037 1.0673886 0.0606946190 2.719928e-02 6.639636e-02 7 28818761 28818789 29 + 0.541 0.099 -3.267
ENSG00000146592 E038 328.3817844 0.0044638761 1.251290e-24 1.318427e-22 7 28819116 28825894 6779 + 2.675 2.359 -1.056