ENSG00000146576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344417 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding protein_coding 29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 16.465981 22.881755 15.2625324 3.9740635 0.28366719 -0.5838888 0.58459583 0.51486667 0.77253333 0.25766667 0.008216431 0.008216431 FALSE TRUE
ENST00000445375 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding protein_coding 29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 2.130030 2.705750 1.0292270 0.2727526 0.05602343 -1.3858396 0.06996250 0.06123333 0.05213333 -0.00910000 0.650372349 0.008216431 FALSE TRUE
ENST00000472693 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding processed_transcript 29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 1.101058 3.860320 0.0000000 2.5784142 0.00000000 -8.5963091 0.02767917 0.09346667 0.00000000 -0.09346667 0.248843643 0.008216431 FALSE TRUE
ENST00000477298 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding retained_intron 29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 2.738524 2.557107 1.9733801 0.4908007 0.12518091 -0.3721821 0.10127500 0.05726667 0.09986667 0.04260000 0.035221397 0.008216431 FALSE TRUE
MSTRG.29472.3 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding   29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 3.375002 6.410319 0.3251595 0.9111618 0.21710414 -4.2597252 0.10913333 0.14846667 0.01680000 -0.13166667 0.038259578 0.008216431 FALSE TRUE
MSTRG.29472.4 ENSG00000146576 HEK293_OSMI2_2hA HEK293_TMG_2hB C7orf26 protein_coding   29.06366 43.9976 19.75606 2.465365 0.3099091 -1.154727 2.550821 5.088442 0.7272041 1.2157994 0.27060926 -2.7899203 0.08100000 0.11330000 0.03650000 -0.07680000 0.103718594 0.008216431 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146576 E001 33.474361 0.1015793595 6.245480e-03 1.925729e-02 7 6590021 6590143 123 + 1.738 1.331 -1.392
ENSG00000146576 E002 27.123054 0.0807530335 7.610374e-03 2.279935e-02 7 6590144 6590162 19 + 1.633 1.255 -1.304
ENSG00000146576 E003 21.855719 0.0821484252 3.015939e-02 7.227866e-02 7 6590163 6590174 12 + 1.508 1.191 -1.105
ENSG00000146576 E004 167.135674 0.0144411974 2.272452e-01 3.591109e-01 7 6590175 6590475 301 + 2.213 2.143 -0.235
ENSG00000146576 E005 138.190315 0.0049226230 7.123040e-01 8.090838e-01 7 6591646 6591702 57 + 2.094 2.075 -0.064
ENSG00000146576 E006 159.488636 0.0003433729 6.497814e-02 1.349993e-01 7 6591703 6591752 50 + 2.185 2.123 -0.207
ENSG00000146576 E007 127.983854 0.0002960481 3.183666e-02 7.553930e-02 7 6591753 6591756 4 + 2.102 2.024 -0.261
ENSG00000146576 E008 290.714931 0.0002921491 4.087086e-03 1.338669e-02 7 6591757 6591867 111 + 2.451 2.380 -0.235
ENSG00000146576 E009 1.368239 0.0095540343 7.973856e-01 8.707062e-01 7 6594412 6594434 23 + 0.306 0.351 0.284
ENSG00000146576 E010 384.534079 0.0001482033 3.097609e-02 7.387027e-02 7 6594435 6594600 166 + 2.554 2.508 -0.155
ENSG00000146576 E011 248.597172 0.0025820971 9.900285e-01 9.978570e-01 7 6599829 6599892 64 + 2.335 2.333 -0.009
ENSG00000146576 E012 250.080211 0.0010248404 1.513966e-01 2.635670e-01 7 6599893 6599973 81 + 2.306 2.344 0.127
ENSG00000146576 E013 220.668002 0.0027727210 1.660834e-01 2.831076e-01 7 6599974 6600036 63 + 2.247 2.295 0.160
ENSG00000146576 E014 255.202410 0.0005216655 8.881121e-01 9.324801e-01 7 6600037 6600126 90 + 2.346 2.345 -0.001
ENSG00000146576 E015 222.954832 0.0002047045 3.142634e-01 4.569764e-01 7 6600127 6600199 73 + 2.269 2.291 0.075
ENSG00000146576 E016 267.165547 0.0002025796 7.594070e-02 1.530146e-01 7 6600200 6600356 157 + 2.333 2.372 0.131
ENSG00000146576 E017 133.041131 0.0006931013 9.673349e-03 2.795794e-02 7 6602101 6602140 40 + 1.991 2.083 0.308
ENSG00000146576 E018 16.386265 0.0010865444 5.097525e-02 1.109031e-01 7 6602141 6602316 176 + 1.299 1.122 -0.625
ENSG00000146576 E019 12.548892 0.0045692970 2.322411e-03 8.220330e-03 7 6602664 6602752 89 + 1.276 0.969 -1.104
ENSG00000146576 E020 23.404850 0.0009319046 1.942555e-02 5.025758e-02 7 6607537 6607597 61 + 1.170 1.365 0.687
ENSG00000146576 E021 21.383981 0.0008955151 4.491322e-01 5.903350e-01 7 6607598 6607851 254 + 1.239 1.298 0.209
ENSG00000146576 E022 586.958208 0.0013326880 8.703591e-07 7.322450e-06 7 6607960 6608726 767 + 2.624 2.731 0.355