ENSG00000146556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538033 ENSG00000146556 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH2P transcribed_unprocessed_pseudogene retained_intron 8.659368 11.81997 5.288089 1.068068 0.5267887 -1.158902 5.1892183 5.0647820 3.05751610 0.53218783 0.25925957 -0.72627494 0.59225417 0.42753333 0.57983333 0.15230000 0.001031105 0.001031105 TRUE FALSE
MSTRG.19093.12 ENSG00000146556 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH2P transcribed_unprocessed_pseudogene   8.659368 11.81997 5.288089 1.068068 0.5267887 -1.158902 0.9839409 1.7653039 1.04185073 0.25295083 0.14911931 -0.75513604 0.12532917 0.14810000 0.19556667 0.04746667 0.334343176 0.001031105 TRUE TRUE
MSTRG.19093.16 ENSG00000146556 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH2P transcribed_unprocessed_pseudogene   8.659368 11.81997 5.288089 1.068068 0.5267887 -1.158902 0.3301540 1.3436692 0.08660303 0.38382187 0.08660303 -3.80866291 0.03206250 0.10986667 0.01376667 -0.09610000 0.063425438 0.001031105 TRUE TRUE
MSTRG.19093.17 ENSG00000146556 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH2P transcribed_unprocessed_pseudogene   8.659368 11.81997 5.288089 1.068068 0.5267887 -1.158902 0.2952932 1.0189825 0.05057385 0.17135310 0.05057385 -4.08637942 0.02979167 0.08533333 0.01123333 -0.07410000 0.041976007 0.001031105 TRUE FALSE
MSTRG.19093.9 ENSG00000146556 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH2P transcribed_unprocessed_pseudogene   8.659368 11.81997 5.288089 1.068068 0.5267887 -1.158902 0.3430300 0.4455773 0.46421053 0.02696923 0.08427410 0.05783177 0.04488333 0.03790000 0.09090000 0.05300000 0.064193417 0.001031105 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146556 E001 0.5138669 0.0208743454 0.2069238686 0.334866152 2 113583593 113583603 11 + 0.297 0.085 -2.181
ENSG00000146556 E002 0.6590396 0.0299406641 0.0747510090 0.151135052 2 113583604 113583622 19 + 0.393 0.085 -2.764
ENSG00000146556 E003 0.5138669 0.0208743454 0.2069238686 0.334866152 2 113583623 113583636 14 + 0.297 0.085 -2.181
ENSG00000146556 E004 0.5138669 0.0208743454 0.2069238686 0.334866152 2 113583637 113583639 3 + 0.297 0.085 -2.181
ENSG00000146556 E005 0.5138669 0.0208743454 0.2069238686 0.334866152 2 113583640 113583647 8 + 0.297 0.085 -2.181
ENSG00000146556 E006 0.6213751 0.0215423611 0.0732880615 0.148777388 2 113583648 113583654 7 + 0.393 0.085 -2.767
ENSG00000146556 E007 1.5060246 0.0093905011 0.3948917109 0.538728342 2 113583655 113583684 30 + 0.471 0.318 -0.860
ENSG00000146556 E008 3.7139737 0.0050243626 0.8221972289 0.887881335 2 113583685 113583735 51 + 0.596 0.628 0.141
ENSG00000146556 E009 8.8703255 0.0021066294 0.4317331631 0.574262974 2 113583736 113583922 187 + 1.014 0.921 -0.344
ENSG00000146556 E010 5.3025686 0.0365676109 0.3407079300 0.484645787 2 113583923 113583928 6 + 0.868 0.722 -0.576
ENSG00000146556 E011 4.4254819 0.0049387183 0.0630814660 0.131840988 2 113583929 113584024 96 + 0.868 0.605 -1.076
ENSG00000146556 E012 1.4005186 0.0116757675 0.8654411218 0.917314133 2 113584025 113584049 25 + 0.393 0.360 -0.187
ENSG00000146556 E013 0.4470576 0.0213558110 0.2057988074 0.333412864 2 113584050 113584102 53 + 0.297 0.085 -2.185
ENSG00000146556 E014 0.4460135 0.0247901669 0.0159017540 0.042514735 2 113584103 113584103 1 + 0.393 0.000 -11.563
ENSG00000146556 E015 0.7394793 0.0157048621 0.0246769690 0.061218853 2 113584104 113584108 5 + 0.472 0.085 -3.184
ENSG00000146556 E016 7.3469732 0.0060793954 0.1391508919 0.246894992 2 113584109 113584136 28 + 0.993 0.807 -0.707
ENSG00000146556 E017 18.1341397 0.0014358112 0.0825224109 0.163487656 2 113588550 113588703 154 + 1.334 1.189 -0.510
ENSG00000146556 E018 3.1762606 0.0056994642 0.7788424344 0.857735422 2 113594176 113594256 81 + 0.538 0.581 0.197
ENSG00000146556 E019 4.2198019 0.0050680117 0.3344379830 0.478186936 2 113594257 113594362 106 + 0.771 0.627 -0.598
ENSG00000146556 E020 3.8060537 0.0044101116 0.7205140220 0.815117855 2 113594363 113594389 27 + 0.596 0.649 0.232
ENSG00000146556 E021 5.0582660 0.0041842741 0.9309197720 0.960534830 2 113594390 113594516 127 + 0.733 0.743 0.039
ENSG00000146556 E022 10.9623773 0.0161959041 0.0906463237 0.176148057 2 113594517 113595049 533 + 1.168 0.972 -0.712
ENSG00000146556 E023 1.2929984 0.0118212081 0.2644477360 0.402416404 2 113595050 113595059 10 + 0.472 0.270 -1.184
ENSG00000146556 E024 1.6229960 0.0098547950 0.5421542264 0.672957672 2 113595060 113595062 3 + 0.472 0.361 -0.599
ENSG00000146556 E025 8.0339089 0.0022546719 0.6330813207 0.747843223 2 113595063 113595161 99 + 0.947 0.886 -0.228
ENSG00000146556 E026 17.4805119 0.0031174200 0.0257118498 0.063343253 2 113595369 113595515 147 + 1.053 1.262 0.747
ENSG00000146556 E027 24.1408606 0.0048420976 0.5638015363 0.691224068 2 113595693 113595829 137 + 1.314 1.355 0.143
ENSG00000146556 E028 11.2673277 0.0016498327 0.6575135353 0.766859961 2 113595830 113595909 80 + 1.071 1.021 -0.183
ENSG00000146556 E029 11.1020071 0.0058925080 0.9854066058 0.994901514 2 113595910 113596067 158 + 1.034 1.031 -0.011
ENSG00000146556 E030 24.2001191 0.0047827205 0.2494689453 0.385283153 2 113596068 113596203 136 + 1.282 1.371 0.310
ENSG00000146556 E031 17.5693246 0.0010482957 0.9979298191 1.000000000 2 113596381 113596578 198 + 1.223 1.219 -0.013
ENSG00000146556 E032 0.0000000       2 113596579 113596582 4 +      
ENSG00000146556 E033 1.6584824 0.0094302775 0.4496154368 0.590818097 2 113596671 113596829 159 + 0.297 0.435 0.815
ENSG00000146556 E034 22.6527096 0.0249828240 0.7562383393 0.841354983 2 113597486 113597638 153 + 1.344 1.320 -0.085
ENSG00000146556 E035 25.9197047 0.0009892638 0.9070258531 0.944999730 2 113598398 113598466 69 + 1.381 1.386 0.016
ENSG00000146556 E036 11.7737416 0.0017030132 0.2894261211 0.430103703 2 113598467 113598606 140 + 0.970 1.080 0.402
ENSG00000146556 E037 66.0109556 0.0005187162 0.0007257999 0.002991811 2 113598607 113599081 475 + 1.659 1.809 0.508