ENSG00000146555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389531 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding protein_coding 3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 0.5189946 0.36174084 0.8356958 0.24673503 0.23205367 1.18584168 0.1505125 0.1010000 0.2112333 0.1102333 3.636658e-01 2.623838e-11 FALSE TRUE
ENST00000404826 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding protein_coding 3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 1.5118847 2.07933045 1.5974452 0.21391189 0.08676864 -0.37827117 0.4141708 0.5290667 0.4061333 -0.1229333 1.428909e-01 2.623838e-11 FALSE TRUE
ENST00000466611 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding processed_transcript 3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 0.1509144 0.49425749 0.0000000 0.28896654 0.00000000 -5.65608869 0.0360250 0.1136333 0.0000000 -0.1136333 1.275758e-01 2.623838e-11 FALSE TRUE
ENST00000476701 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding retained_intron 3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 0.2552299 0.60361334 0.0000000 0.30183923 0.00000000 -5.93925795 0.0614625 0.1466000 0.0000000 -0.1466000 1.315718e-01 2.623838e-11 FALSE TRUE
MSTRG.29412.3 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding   3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 0.6621278 0.03767083 1.1983000 0.03767083 0.04981223 4.66372818 0.2022667 0.0111000 0.3042667 0.2931667 2.623838e-11 2.623838e-11 FALSE TRUE
MSTRG.29412.5 ENSG00000146555 HEK293_OSMI2_2hA HEK293_TMG_2hB SDK1 protein_coding   3.545141 3.940669 3.949963 0.455202 0.1022598 0.003389885 0.3293255 0.21124659 0.2195826 0.21124659 0.21958258 0.05335792 0.1047083 0.0623000 0.0540000 -0.0083000 1.000000e+00 2.623838e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146555 E001 4.7312980 0.1115359896 9.017771e-04 3.619853e-03 7 3301252 3301586 335 + 0.992 0.305 -3.114
ENSG00000146555 E002 1.1696869 0.1772611186 8.966403e-03 2.619526e-02 7 3301587 3301679 93 + 0.547 0.000 -14.422
ENSG00000146555 E003 0.2944980 0.3489775271 2.947209e-01   7 3301680 3301749 70 + 0.213 0.000 -12.119
ENSG00000146555 E004 2.7175537 0.0067047540 5.135202e-01 6.483378e-01 7 3301750 3301844 95 + 0.620 0.524 -0.436
ENSG00000146555 E005 4.0944270 0.0038152652 6.063708e-01 7.265427e-01 7 3301845 3301884 40 + 0.735 0.670 -0.269
ENSG00000146555 E006 14.8545450 0.0012287456 1.328349e-01 2.380497e-01 7 3619080 3619239 160 + 1.258 1.137 -0.428
ENSG00000146555 E007 17.2061316 0.0132473135 3.275857e-01 4.710495e-01 7 3639004 3639110 107 + 1.301 1.216 -0.298
ENSG00000146555 E008 31.0481261 0.0115923164 1.397215e-02 3.816073e-02 7 3641958 3642105 148 + 1.591 1.407 -0.630
ENSG00000146555 E009 32.6254652 0.0006634310 2.740701e-03 9.494261e-03 7 3821450 3821583 134 + 1.605 1.433 -0.589
ENSG00000146555 E010 0.2214452 0.0382177460 4.726015e-01   7 3950920 3950920 1 + 0.000 0.126 11.434
ENSG00000146555 E011 0.2214452 0.0382177460 4.726015e-01   7 3950921 3950922 2 + 0.000 0.126 11.434
ENSG00000146555 E012 25.4134674 0.0008104981 8.092704e-03 2.401495e-02 7 3950923 3951034 112 + 1.501 1.331 -0.590
ENSG00000146555 E013 25.5735923 0.0007795394 7.871487e-04 3.213311e-03 7 3951730 3951920 191 + 1.522 1.303 -0.760
ENSG00000146555 E014 0.1482932 0.0424881307 4.740572e-01   7 3951921 3952109 189 + 0.000 0.125 11.396
ENSG00000146555 E015 0.2998086 0.0303921335 9.826889e-01   7 3958040 3958287 248 + 0.119 0.125 0.076
ENSG00000146555 E016 16.3533517 0.0029755809 2.168453e-04 1.036031e-03 7 3958931 3959014 84 + 1.371 1.056 -1.114
ENSG00000146555 E017 29.2628236 0.0006897273 3.562937e-08 3.951918e-07 7 3962657 3962851 195 + 1.625 1.273 -1.215
ENSG00000146555 E018 25.3782141 0.0066546053 3.351888e-05 1.969497e-04 7 3967318 3967434 117 + 1.558 1.241 -1.099
ENSG00000146555 E019 28.0595331 0.0100402215 1.028396e-02 2.946517e-02 7 3969257 3969424 168 + 1.555 1.357 -0.680
ENSG00000146555 E020 25.5035362 0.0072786417 1.526864e-02 4.109563e-02 7 3971466 3971568 103 + 1.510 1.330 -0.623
ENSG00000146555 E021 30.8581257 0.0008014484 3.850533e-02 8.828814e-02 7 3974369 3974545 177 + 1.562 1.443 -0.407
ENSG00000146555 E022 0.3686942 0.0297411002 9.807812e-01 9.919708e-01 7 3974546 3974758 213 + 0.119 0.126 0.082
ENSG00000146555 E023 26.9158795 0.0007886345 5.234580e-02 1.133369e-01 7 3987186 3987322 137 + 1.506 1.388 -0.407
ENSG00000146555 E024 25.5732151 0.0018796856 4.066813e-03 1.332928e-02 7 4010966 4011113 148 + 1.514 1.324 -0.658
ENSG00000146555 E025 26.1617608 0.0169815270 4.035654e-01 5.473333e-01 7 4012095 4012235 141 + 1.461 1.402 -0.202
ENSG00000146555 E026 27.4132292 0.0057340994 2.103766e-03 7.545478e-03 7 4017171 4017352 182 + 1.554 1.338 -0.747
ENSG00000146555 E027 24.3854872 0.0053195867 8.684724e-05 4.603125e-04 7 4049348 4049463 116 + 1.535 1.241 -1.019
ENSG00000146555 E028 33.4330554 0.0091333507 2.190765e-03 7.813284e-03 7 4051638 4051830 193 + 1.635 1.419 -0.740
ENSG00000146555 E029 22.1487028 0.0008659074 3.420770e-05 2.005678e-04 7 4067838 4067936 99 + 1.493 1.196 -1.031
ENSG00000146555 E030 37.9755942 0.0140607320 3.799911e-02 8.735098e-02 7 4076998 4077189 192 + 1.666 1.514 -0.515
ENSG00000146555 E031 32.5706374 0.0124994885 7.336669e-01 8.248332e-01 7 4079463 4079584 122 + 1.534 1.519 -0.051
ENSG00000146555 E032 28.7786323 0.0037972027 5.073828e-01 6.429403e-01 7 4110663 4110772 110 + 1.441 1.498 0.196
ENSG00000146555 E033 34.4669556 0.0006226544 3.274502e-01 4.709177e-01 7 4113289 4113439 151 + 1.506 1.574 0.233
ENSG00000146555 E034 42.4357059 0.0105923176 6.229062e-01 7.396192e-01 7 4114037 4114274 238 + 1.605 1.653 0.165
ENSG00000146555 E035 27.8700402 0.0012276437 3.384840e-01 4.823516e-01 7 4127381 4127496 116 + 1.410 1.484 0.255
ENSG00000146555 E036 0.3729606 0.0301367135 9.811423e-01 9.922354e-01 7 4129685 4129907 223 + 0.119 0.126 0.082
ENSG00000146555 E037 35.2660263 0.0051593508 4.231976e-01 5.663012e-01 7 4129908 4130097 190 + 1.573 1.531 -0.142
ENSG00000146555 E038 26.6075805 0.0010861842 3.002057e-01 4.418660e-01 7 4132325 4132423 99 + 1.465 1.405 -0.206
ENSG00000146555 E039 32.4768790 0.0055383847 5.435170e-01 6.741060e-01 7 4145722 4145916 195 + 1.531 1.500 -0.104
ENSG00000146555 E040 37.5651711 0.0197061112 9.851609e-01 9.947329e-01 7 4149262 4149463 202 + 1.566 1.587 0.073
ENSG00000146555 E041 33.2347933 0.0140325161 8.016348e-01 8.736040e-01 7 4158448 4158551 104 + 1.527 1.523 -0.013
ENSG00000146555 E042 27.2320353 0.0027697686 8.606380e-01 9.141205e-01 7 4161786 4161856 71 + 1.441 1.439 -0.006
ENSG00000146555 E043 38.7697535 0.0006256323 7.137410e-01 8.101429e-01 7 4174222 4174357 136 + 1.573 1.604 0.105
ENSG00000146555 E044 17.6668581 0.0136214666 5.222506e-01 6.560842e-01 7 4175775 4175834 60 + 1.218 1.293 0.263
ENSG00000146555 E045 29.0562534 0.0007312423 5.635132e-01 6.909721e-01 7 4178485 4178586 102 + 1.446 1.493 0.162
ENSG00000146555 E046 0.0000000       7 4179124 4179258 135 +      
ENSG00000146555 E047 27.7432849 0.0007419506 4.185638e-01 5.618204e-01 7 4205879 4205994 116 + 1.421 1.483 0.216
ENSG00000146555 E048 35.1421691 0.0054629604 1.718223e-01 2.905829e-01 7 4208099 4208285 187 + 1.497 1.600 0.353
ENSG00000146555 E049 30.6892768 0.0008490351 5.233834e-02 1.133247e-01 7 4210025 4210162 138 + 1.426 1.558 0.453
ENSG00000146555 E050 41.0033599 0.0120966845 1.950391e-02 5.042221e-02 7 4220109 4220270 162 + 1.515 1.701 0.636
ENSG00000146555 E051 36.7666259 0.0149879816 2.036621e-01 3.307914e-01 7 4221239 4221364 126 + 1.514 1.631 0.397
ENSG00000146555 E052 0.1482932 0.0424881307 4.740572e-01   7 4227155 4227423 269 + 0.000 0.125 11.396
ENSG00000146555 E053 0.3697384 0.0249779345 1.907393e-01 3.146797e-01 7 4232887 4233254 368 + 0.000 0.222 12.513
ENSG00000146555 E054 41.9373395 0.0032283850 4.776874e-01 6.162006e-01 7 4233255 4233419 165 + 1.605 1.657 0.178
ENSG00000146555 E055 32.3476173 0.0009689173 5.697152e-02 1.214097e-01 7 4237647 4237784 138 + 1.446 1.574 0.438
ENSG00000146555 E056 33.5173409 0.0006259328 6.781266e-02 1.397360e-01 7 4241793 4241913 121 + 1.465 1.585 0.411
ENSG00000146555 E057 36.7294707 0.0006197304 5.828384e-02 1.236835e-01 7 4245676 4245805 130 + 1.506 1.625 0.407
ENSG00000146555 E058 26.2879719 0.0034374356 1.354334e-01 2.417185e-01 7 4265124 4265248 125 + 1.371 1.488 0.403
ENSG00000146555 E059 122.3839661 0.0024964609 3.823615e-07 3.460433e-06 7 4265249 4266095 847 + 1.957 2.169 0.709
ENSG00000146555 E060 180.4650714 0.0025133022 1.043908e-08 1.281776e-07 7 4266096 4268324 2229 + 2.131 2.338 0.692
ENSG00000146555 E061 46.3794913 0.0219999892 1.032707e-03 4.071574e-03 7 4268325 4268677 353 + 1.484 1.789 1.038
ENSG00000146555 E062 33.9613215 0.0352704264 3.104727e-02 7.400882e-02 7 4268678 4269000 323 + 1.388 1.646 0.884