ENSG00000146463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314607 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding protein_coding 17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 3.277482 0.4201232 5.718958 0.04948019 0.4243398 3.7354509 0.16285417 0.06646667 0.2069000 0.1404333 2.417124e-05 2.417124e-05 FALSE TRUE
MSTRG.818.1 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding   17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 1.138921 0.1753258 3.023787 0.07614439 0.3513427 4.0329844 0.05425417 0.02783333 0.1102333 0.0824000 6.063909e-03 2.417124e-05 FALSE TRUE
MSTRG.818.10 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding   17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 1.665774 0.0000000 2.145731 0.00000000 2.1457312 7.7520335 0.10921667 0.00000000 0.0820000 0.0820000 1.000000e+00 2.417124e-05 FALSE TRUE
MSTRG.818.5 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding   17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 2.509933 0.1947543 7.216294 0.19475431 3.6242551 5.1412902 0.09765417 0.03370000 0.2545333 0.2208333 5.109913e-01 2.417124e-05 FALSE TRUE
MSTRG.818.6 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding   17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 3.229055 1.5248043 3.391637 0.85019663 0.6727502 1.1481746 0.14325833 0.22386667 0.1210000 -0.1028667 9.779448e-01 2.417124e-05 FALSE TRUE
MSTRG.818.7 ENSG00000146463 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM4 protein_coding   17.57407 6.413005 27.70293 0.3726868 1.037945 2.109239 3.494665 3.7439058 3.207742 0.45683669 0.5239003 -0.2223438 0.31629167 0.59586667 0.1175000 -0.4783667 1.027108e-04 2.417124e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146463 E001 0.8867284 0.0170630891 8.998911e-01 9.401383e-01 1 35268638 35268708 71 + 0.238 0.236 -0.015
ENSG00000146463 E002 31.5704560 0.0077686573 7.620717e-09 9.600492e-08 1 35268709 35269032 324 + 1.487 0.876 -2.187
ENSG00000146463 E003 33.9354376 0.0011654785 4.305577e-08 4.705657e-07 1 35269033 35269085 53 + 1.507 1.047 -1.619
ENSG00000146463 E004 2.5185639 0.0065479791 1.468479e-02 3.977792e-02 1 35269086 35269094 9 + 0.542 0.000 -12.132
ENSG00000146463 E005 3.4613787 0.0178082977 4.329941e-02 9.711131e-02 1 35284673 35284706 34 + 0.625 0.237 -2.149
ENSG00000146463 E006 0.0000000       1 35294277 35294336 60 +      
ENSG00000146463 E007 20.4944803 0.0059787416 1.528814e-06 1.220108e-05 1 35295927 35295988 62 + 1.304 0.728 -2.139
ENSG00000146463 E008 1.5510666 0.0228338443 4.467781e-01 5.882447e-01 1 35305564 35305686 123 + 0.365 0.237 -0.859
ENSG00000146463 E009 0.2966881 0.0269176518 1.000000e+00   1 35322711 35322832 122 + 0.111 0.000 -9.044
ENSG00000146463 E010 42.6592283 0.0004775553 1.110725e-09 1.632964e-08 1 35325360 35325405 46 + 1.601 1.147 -1.577
ENSG00000146463 E011 195.3363489 0.0002648607 8.077235e-18 4.014186e-16 1 35358925 35359446 522 + 2.231 1.982 -0.835
ENSG00000146463 E012 67.6710190 0.0004494203 2.478594e-04 1.166266e-03 1 35361194 35361255 62 + 1.761 1.611 -0.510
ENSG00000146463 E013 76.4139742 0.0003569212 4.861081e-05 2.747419e-04 1 35361619 35361704 86 + 1.815 1.655 -0.542
ENSG00000146463 E014 42.8043224 0.0031472881 3.836420e-05 2.221266e-04 1 35361705 35361716 12 + 1.586 1.313 -0.942
ENSG00000146463 E015 74.5512734 0.0026097388 4.058022e-06 2.946986e-05 1 35361717 35361789 73 + 1.814 1.588 -0.766
ENSG00000146463 E016 88.2686186 0.0112352392 2.366162e-05 1.443086e-04 1 35370029 35370113 85 + 1.890 1.637 -0.853
ENSG00000146463 E017 134.1523992 0.0055016368 6.425737e-07 5.560646e-06 1 35370372 35370627 256 + 2.066 1.850 -0.723
ENSG00000146463 E018 0.7708142 0.0153787590 9.857486e-01 9.951195e-01 1 35370628 35370853 226 + 0.200 0.237 0.309
ENSG00000146463 E019 109.0644357 0.0008004493 3.548440e-06 2.613284e-05 1 35381259 35381433 175 + 1.968 1.811 -0.526
ENSG00000146463 E020 134.6052854 0.0026457829 4.871206e-06 3.478198e-05 1 35381546 35381758 213 + 2.059 1.903 -0.522
ENSG00000146463 E021 112.2069703 0.0002960470 1.160060e-05 7.595036e-05 1 35385442 35385592 151 + 1.977 1.844 -0.448
ENSG00000146463 E022 89.1343777 0.0002880726 3.815587e-03 1.262446e-02 1 35386074 35386189 116 + 1.869 1.791 -0.262
ENSG00000146463 E023 143.3267910 0.0002730339 6.554459e-06 4.543109e-05 1 35387003 35387278 276 + 2.079 1.965 -0.383
ENSG00000146463 E024 109.5513501 0.0003077737 9.186384e-02 1.780240e-01 1 35387454 35387604 151 + 1.945 1.937 -0.028
ENSG00000146463 E025 128.8191316 0.0047375160 5.105698e-01 6.457607e-01 1 35388910 35389082 173 + 2.007 2.038 0.103
ENSG00000146463 E026 136.7432348 0.0007100563 9.686062e-02 1.856926e-01 1 35389948 35390098 151 + 2.039 2.037 -0.005
ENSG00000146463 E027 111.9500779 0.0004510714 3.966967e-01 5.404669e-01 1 35392212 35392352 141 + 1.947 1.975 0.096
ENSG00000146463 E028 72.5510265 0.0004613482 2.112094e-01 3.399256e-01 1 35392647 35392679 33 + 1.767 1.765 -0.006
ENSG00000146463 E029 51.4124929 0.0010311529 1.279075e-01 2.312512e-01 1 35392680 35392684 5 + 1.629 1.595 -0.113
ENSG00000146463 E030 133.2142090 0.0002751590 2.176737e-01 3.475933e-01 1 35393595 35393739 145 + 2.026 2.043 0.057
ENSG00000146463 E031 63.2052859 0.0011991192 9.880127e-01 9.965523e-01 1 35396552 35396554 3 + 1.696 1.760 0.214
ENSG00000146463 E032 139.0029743 0.0002166440 5.585899e-01 6.867980e-01 1 35396555 35396670 116 + 2.028 2.114 0.286
ENSG00000146463 E033 0.5964967 0.0228530070 7.591222e-01 8.435350e-01 1 35397052 35397123 72 + 0.158 0.236 0.721
ENSG00000146463 E034 195.0474419 0.0002687708 8.864733e-02 1.730659e-01 1 35397377 35397545 169 + 2.191 2.201 0.032
ENSG00000146463 E035 133.5886811 0.0002766081 8.038116e-03 2.387577e-02 1 35398413 35398466 54 + 2.038 1.998 -0.136
ENSG00000146463 E036 217.2747108 0.0029187484 3.371716e-02 7.919064e-02 1 35398864 35399043 180 + 2.243 2.221 -0.072
ENSG00000146463 E037 157.2187244 0.0021030384 9.854205e-01 9.949102e-01 1 35399482 35399576 95 + 2.085 2.148 0.211
ENSG00000146463 E038 0.8815316 0.0136968632 2.380972e-01 3.719289e-01 1 35404844 35405022 179 + 0.274 0.000 -10.629
ENSG00000146463 E039 198.1525982 0.0001994998 9.519324e-01 9.739101e-01 1 35405023 35405194 172 + 2.184 2.250 0.221
ENSG00000146463 E040 120.4562904 0.0002796679 5.109733e-01 6.461029e-01 1 35405373 35405468 96 + 1.964 2.054 0.302
ENSG00000146463 E041 131.9683616 0.0002699133 5.384275e-02 1.159776e-01 1 35408008 35408159 152 + 1.993 2.128 0.453
ENSG00000146463 E042 123.1982822 0.0002886952 1.375721e-01 2.447057e-01 1 35413972 35414083 112 + 1.968 2.089 0.406
ENSG00000146463 E043 231.9767249 0.0026395779 5.402855e-03 1.702293e-02 1 35415466 35415714 249 + 2.230 2.395 0.552
ENSG00000146463 E044 196.4658780 0.0001922588 8.248117e-10 1.241821e-08 1 35418443 35418572 130 + 2.136 2.378 0.806
ENSG00000146463 E045 1000.8701485 0.0070450015 1.016746e-14 3.340029e-13 1 35419470 35422058 2589 + 2.813 3.144 1.099