ENSG00000146457

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337387 ENSG00000146457 HEK293_OSMI2_2hA HEK293_TMG_2hB WTAP protein_coding protein_coding 52.54796 32.52614 80.78268 2.669759 2.030063 1.312182 11.850242 9.360984 11.66267 0.4950161 0.4501743 0.3168617 0.2437708 0.2933000 0.1443333 -0.14896667 0.000810889 0.000810889 FALSE TRUE
ENST00000614346 ENSG00000146457 HEK293_OSMI2_2hA HEK293_TMG_2hB WTAP protein_coding protein_coding 52.54796 32.52614 80.78268 2.669759 2.030063 1.312182 8.985850 4.172136 17.68170 0.4699751 0.5397767 2.0807607 0.1528833 0.1293667 0.2188667 0.08950000 0.002534931 0.000810889 FALSE TRUE
ENST00000621533 ENSG00000146457 HEK293_OSMI2_2hA HEK293_TMG_2hB WTAP protein_coding protein_coding 52.54796 32.52614 80.78268 2.669759 2.030063 1.312182 19.488251 10.816322 34.64403 1.3982866 0.9014915 1.6784801 0.3636333 0.3303000 0.4289333 0.09863333 0.006615897 0.000810889 FALSE TRUE
MSTRG.29279.5 ENSG00000146457 HEK293_OSMI2_2hA HEK293_TMG_2hB WTAP protein_coding   52.54796 32.52614 80.78268 2.669759 2.030063 1.312182 9.695855 6.376616 14.02599 0.7913384 0.5006355 1.1360075 0.1848958 0.1947333 0.1736333 -0.02110000 0.506654500 0.000810889 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146457 E001 2.8933854 0.0086459667 1.354028e-01 2.416776e-01 6 159725585 159726995 1411 + 0.644 0.396 -1.192
ENSG00000146457 E002 0.1472490 0.0430753280 1.000000e+00   6 159726996 159726997 2 + 0.084 0.000 -8.005
ENSG00000146457 E003 159.2490355 0.0002069064 6.134725e-14 1.796854e-12 6 159726998 159727299 302 + 2.246 2.025 -0.740
ENSG00000146457 E004 146.3112032 0.0002122085 2.201507e-10 3.658179e-09 6 159727300 159727333 34 + 2.203 2.013 -0.636
ENSG00000146457 E005 7.5589288 0.0022814385 1.032350e-01 1.954042e-01 6 159727506 159727529 24 + 0.969 0.776 -0.739
ENSG00000146457 E006 31.3683231 0.0039746330 3.959991e-12 8.801131e-11 6 159727530 159727565 36 + 1.615 1.019 -2.090
ENSG00000146457 E007 43.1580035 0.0976864419 3.818148e-04 1.704496e-03 6 159727566 159727587 22 + 1.748 1.174 -1.981
ENSG00000146457 E008 99.2619915 0.0380509656 4.040389e-03 1.325528e-02 6 159727588 159727703 116 + 2.056 1.767 -0.972
ENSG00000146457 E009 271.8378395 0.0002673773 2.297062e-19 1.368894e-17 6 159736258 159736295 38 + 2.473 2.267 -0.685
ENSG00000146457 E010 0.4751703 0.0207246621 2.076270e-01 3.356286e-01 6 159736296 159736718 423 + 0.084 0.300 2.223
ENSG00000146457 E011 324.9509727 0.0012902106 1.969693e-08 2.299719e-07 6 159738990 159739045 56 + 2.532 2.395 -0.456
ENSG00000146457 E012 5.1926003 0.0258585048 9.502501e-01 9.728607e-01 6 159741593 159742087 495 + 0.771 0.776 0.019
ENSG00000146457 E013 356.0408253 0.0001479341 2.520190e-05 1.526741e-04 6 159742088 159742146 59 + 2.552 2.485 -0.222
ENSG00000146457 E014 416.3722514 0.0001749328 4.273236e-04 1.879313e-03 6 159743665 159743792 128 + 2.614 2.566 -0.158
ENSG00000146457 E015 522.9246779 0.0014137748 5.031064e-01 6.390987e-01 6 159748191 159748369 179 + 2.686 2.717 0.101
ENSG00000146457 E016 373.9361701 0.0012667756 9.759877e-11 1.724794e-09 6 159748370 159748589 220 + 2.484 2.657 0.574
ENSG00000146457 E017 508.8847639 0.0004897636 5.224054e-12 1.138874e-10 6 159748590 159748934 345 + 2.631 2.774 0.474
ENSG00000146457 E018 505.0786250 0.0002087507 2.304566e-33 4.989635e-31 6 159748935 159750010 1076 + 2.598 2.814 0.720
ENSG00000146457 E019 302.5243361 0.0001509357 7.450543e-08 7.756680e-07 6 159753460 159753614 155 + 2.493 2.393 -0.334
ENSG00000146457 E020 985.9328513 0.0126624149 2.130661e-01 3.421581e-01 6 159755028 159756319 1292 + 2.941 3.026 0.285