ENSG00000146373

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000454842 ENSG00000146373 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF217 protein_coding processed_transcript 3.96643 5.757652 3.036404 0.4803322 0.3095308 -0.920877 0.32212810 0.31696354 0.3422718 0.09986190 0.08634751 0.1075594 0.08691250 0.055866667 0.1125667 0.05670000 3.183849e-01 9.727172e-11   FALSE
ENST00000521654 ENSG00000146373 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF217 protein_coding protein_coding 3.96643 5.757652 3.036404 0.4803322 0.3095308 -0.920877 0.90338389 0.47615396 1.4713505 0.03594334 0.03151884 1.6074279 0.25082500 0.083966667 0.4946667 0.41070000 9.727172e-11 9.727172e-11 FALSE TRUE
MSTRG.28911.3 ENSG00000146373 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF217 protein_coding   3.96643 5.757652 3.036404 0.4803322 0.3095308 -0.920877 2.13716178 4.52947004 0.6322982 0.54724347 0.22973756 -2.8212087 0.48705833 0.786266667 0.1987333 -0.58753333 2.020472e-06 9.727172e-11   FALSE
MSTRG.28911.5 ENSG00000146373 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF217 protein_coding   3.96643 5.757652 3.036404 0.4803322 0.3095308 -0.920877 0.08590662 0.01468835 0.1953438 0.01468835 0.02685082 3.0561395 0.02612917 0.002233333 0.0669000 0.06466667 3.732669e-05 9.727172e-11 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146373 E001 5.0491106 0.003340669 4.871825e-01 6.248739e-01 6 124962437 124962544 108 + 0.791 0.741 -0.202
ENSG00000146373 E002 42.2537897 0.003810736 5.243767e-11 9.700381e-10 6 124962545 124963248 704 + 1.523 1.732 0.711
ENSG00000146373 E003 17.5051519 0.001912357 3.528027e-07 3.216275e-06 6 124963249 124963307 59 + 1.128 1.379 0.884
ENSG00000146373 E004 27.9813805 0.003461807 1.216022e-13 3.414432e-12 6 124963308 124963426 119 + 1.276 1.614 1.168
ENSG00000146373 E005 11.7024613 0.001601388 2.354780e-20 1.567484e-18 6 124963703 124963821 119 + 0.585 1.386 3.032
ENSG00000146373 E006 2.8775649 0.144430266 3.147400e-01 4.574833e-01 6 124964725 124964893 169 + 0.688 0.354 -1.620
ENSG00000146373 E007 0.5891098 0.018324714 1.963770e-01 3.216975e-01 6 124971255 124971477 223 + 0.309 0.000 -13.784
ENSG00000146373 E008 2.8775874 0.005746056 1.357655e-01 2.421743e-01 6 124971478 124971500 23 + 0.522 0.631 0.491
ENSG00000146373 E009 4.9371336 0.003640184 1.168258e-01 2.154310e-01 6 124971501 124971598 98 + 0.733 0.801 0.273
ENSG00000146373 E010 0.1482932 0.041469098 2.040210e-01   6 124983364 124983367 4 + 0.000 0.149 11.943
ENSG00000146373 E011 0.1482932 0.041469098 2.040210e-01   6 124983368 124983521 154 + 0.000 0.149 11.943
ENSG00000146373 E012 0.3268771 0.030052723 5.261274e-01   6 124996575 124996655 81 + 0.100 0.149 0.660
ENSG00000146373 E013 0.0000000       6 125006076 125006177 102 +      
ENSG00000146373 E014 0.3332198 0.030387515 5.266474e-01   6 125008755 125008922 168 + 0.100 0.149 0.660
ENSG00000146373 E015 1.4350637 0.192627908 8.853283e-01 9.306610e-01 6 125009174 125009282 109 + 0.407 0.349 -0.333
ENSG00000146373 E016 0.7019140 0.016603742 3.981830e-01 5.419245e-01 6 125009283 125009489 207 + 0.181 0.260 0.661
ENSG00000146373 E017 12.7464845 0.001688229 2.295431e-02 5.765002e-02 6 125045211 125045302 92 + 1.111 1.161 0.181
ENSG00000146373 E018 16.5985613 0.008679678 1.128938e-02 3.185064e-02 6 125045303 125045444 142 + 1.204 1.271 0.236
ENSG00000146373 E019 2.3134697 0.018785664 2.105733e-02 5.371494e-02 6 125045507 125045554 48 + 0.361 0.632 1.345
ENSG00000146373 E020 0.0000000       6 125046600 125046606 7 +      
ENSG00000146373 E021 0.0000000       6 125046607 125046661 55 +      
ENSG00000146373 E022 0.2214452 0.037908224 2.024747e-01   6 125048152 125048259 108 + 0.000 0.149 11.966
ENSG00000146373 E023 17.6479043 0.001030902 9.143106e-01 9.497390e-01 6 125057942 125058106 165 + 1.337 1.161 -0.618
ENSG00000146373 E024 21.1728341 0.002393146 6.256693e-01 7.417516e-01 6 125076657 125076858 202 + 1.425 1.218 -0.723
ENSG00000146373 E025 11.4913621 0.003943649 1.851236e-01 3.076320e-01 6 125081436 125081507 72 + 1.205 0.900 -1.112
ENSG00000146373 E026 0.2987644 0.027439108 5.573193e-01   6 125082449 125082563 115 + 0.181 0.000 -12.845
ENSG00000146373 E027 264.7371568 0.017933287 1.301899e-13 3.643683e-12 6 125082864 125092633 9770 + 2.562 2.118 -1.482