ENSG00000146263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000496119 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding nonsense_mediated_decay 10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 1.0464556 0.25937812 1.912273 0.25937812 0.19483274 2.835109 0.06805417 0.07966667 0.11403333 0.03436667 4.273594e-01 3.499296e-06 FALSE TRUE
ENST00000506256 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding processed_transcript 10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 1.2471117 0.49426080 2.319944 0.02603019 0.14656160 2.208053 0.12069167 0.18196667 0.13850000 -0.04346667 4.667848e-01 3.499296e-06 FALSE TRUE
ENST00000511335 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding retained_intron 10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 0.6962856 0.29322359 1.331606 0.01060468 0.09135681 2.145507 0.08900417 0.10903333 0.07983333 -0.02920000 5.516129e-01 3.499296e-06   FALSE
ENST00000683635 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding protein_coding 10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 3.0203251 1.25401356 4.059106 0.05703821 0.40633944 1.686700 0.36847083 0.46640000 0.24350000 -0.22290000 1.462289e-02 3.499296e-06 FALSE TRUE
MSTRG.28676.13 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding   10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 1.1585794 0.24205781 2.437390 0.05156546 0.16416116 3.279418 0.11017083 0.08810000 0.14583333 0.05773333 1.750980e-01 3.499296e-06 FALSE TRUE
MSTRG.28676.4 ENSG00000146263 HEK293_OSMI2_2hA HEK293_TMG_2hB MMS22L protein_coding   10.7862 2.750366 16.72757 0.2712779 0.2821589 2.600159 2.0975807 0.04828251 2.939912 0.04828251 0.29789487 5.661465 0.12402500 0.01483333 0.17546667 0.16063333 3.499296e-06 3.499296e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146263 E001 297.2656154 0.0021796648 3.334415e-10 5.383667e-09 6 97142161 97146544 4384 - 2.339 2.530 0.636
ENSG00000146263 E002 12.9765167 0.0163337700 1.669567e-02 4.426608e-02 6 97146545 97146736 192 - 0.980 1.266 1.028
ENSG00000146263 E003 28.0246415 0.0011377348 5.949056e-05 3.289160e-04 6 97146737 97146887 151 - 1.296 1.600 1.046
ENSG00000146263 E004 47.1653481 0.0128979621 1.213161e-01 2.218009e-01 6 97149853 97150020 168 - 1.565 1.708 0.486
ENSG00000146263 E005 0.1451727 0.0433363903 1.000000e+00   6 97151578 97151770 193 - 0.062 0.000 -8.425
ENSG00000146263 E006 39.6988443 0.0006638904 6.246748e-01 7.409436e-01 6 97151771 97151867 97 - 1.514 1.560 0.161
ENSG00000146263 E007 47.9975030 0.0005080099 7.178460e-01 8.131180e-01 6 97162002 97162165 164 - 1.593 1.629 0.123
ENSG00000146263 E008 33.8614524 0.0007864643 3.654958e-02 8.462318e-02 6 97165246 97165339 94 - 1.418 1.577 0.543
ENSG00000146263 E009 32.2445121 0.0006795449 1.682539e-01 2.859300e-01 6 97165340 97165457 118 - 1.413 1.526 0.387
ENSG00000146263 E010 41.4663707 0.0007097942 3.688666e-01 5.132850e-01 6 97168071 97168240 170 - 1.528 1.600 0.247
ENSG00000146263 E011 38.1810271 0.0005303562 9.004779e-01 9.405065e-01 6 97173063 97173222 160 - 1.503 1.526 0.078
ENSG00000146263 E012 33.1806295 0.0008084146 4.114157e-01 5.549805e-01 6 97178443 97178585 143 - 1.462 1.414 -0.165
ENSG00000146263 E013 32.2888501 0.0011278510 9.957231e-01 1.000000e+00 6 97179408 97179559 152 - 1.433 1.448 0.049
ENSG00000146263 E014 31.7152518 0.0006348468 1.222935e-01 2.232170e-01 6 97181904 97182054 151 - 1.448 1.338 -0.379
ENSG00000146263 E015 37.5437430 0.0005941556 1.813867e-02 4.742822e-02 6 97186497 97186690 194 - 1.530 1.365 -0.567
ENSG00000146263 E016 69.5825812 0.0003820356 2.439593e-05 1.483894e-04 6 97228894 97229403 510 - 1.800 1.569 -0.783
ENSG00000146263 E017 2.1110567 0.0072575072 7.909159e-01 8.662903e-01 6 97230269 97231425 1157 - 0.428 0.488 0.306
ENSG00000146263 E018 39.9432667 0.0072770396 3.123886e-01 4.549382e-01 6 97231426 97231652 227 - 1.539 1.469 -0.241
ENSG00000146263 E019 29.1732444 0.0013027429 6.729079e-01 7.787297e-01 6 97233861 97233980 120 - 1.398 1.378 -0.069
ENSG00000146263 E020 0.7436440 0.1137222933 6.942482e-02 1.424028e-01 6 97245979 97246156 178 - 0.116 0.483 2.740
ENSG00000146263 E021 21.5255561 0.0015523210 2.564333e-01 3.933984e-01 6 97246628 97246690 63 - 1.286 1.192 -0.333
ENSG00000146263 E022 0.1515154 0.0432958052 1.000000e+00   6 97253465 97254556 1092 - 0.062 0.000 -8.426
ENSG00000146263 E023 39.4748601 0.0005709898 5.665280e-05 3.148898e-04 6 97254557 97254733 177 - 1.569 1.263 -1.057
ENSG00000146263 E024 62.1960682 0.0046347943 1.674039e-05 1.056611e-04 6 97258663 97259371 709 - 1.646 1.909 0.892
ENSG00000146263 E025 36.1691300 0.0007568744 4.521123e-01 5.930053e-01 6 97259372 97259662 291 - 1.469 1.535 0.228
ENSG00000146263 E026 7.5725447 0.0027422080 5.004160e-01 6.366713e-01 6 97259663 97259669 7 - 0.833 0.936 0.393
ENSG00000146263 E027 75.9255392 0.0158690727 6.576326e-02 1.363070e-01 6 97259670 97261084 1415 - 1.824 1.684 -0.474
ENSG00000146263 E028 40.0380644 0.0006554128 3.333860e-02 7.845933e-02 6 97261085 97261974 890 - 1.554 1.414 -0.481
ENSG00000146263 E029 16.5869474 0.0130436819 2.458051e-03 8.637924e-03 6 97261975 97262178 204 - 1.219 0.817 -1.486
ENSG00000146263 E030 53.3763851 0.0004739528 4.161020e-04 1.836185e-03 6 97263335 97263448 114 - 1.686 1.469 -0.741
ENSG00000146263 E031 3.6494352 0.0042961320 1.747232e-01 2.943469e-01 6 97263449 97265719 2271 - 0.537 0.767 0.990
ENSG00000146263 E032 2.8235693 0.0073474640 3.379950e-01 4.818795e-01 6 97265720 97267871 2152 - 0.556 0.378 -0.907
ENSG00000146263 E033 33.4322823 0.0006199063 7.808456e-02 1.563952e-01 6 97267872 97267903 32 - 1.475 1.352 -0.426
ENSG00000146263 E034 47.8591077 0.0007932552 2.078518e-02 5.313662e-02 6 97267904 97268002 99 - 1.629 1.489 -0.480
ENSG00000146263 E035 51.6227746 0.0005463146 2.181282e-03 7.784005e-03 6 97269902 97269992 91 - 1.666 1.479 -0.640
ENSG00000146263 E036 0.9360593 0.4104275483 3.867461e-01 5.309229e-01 6 97269993 97270106 114 - 0.209 0.374 1.148
ENSG00000146263 E037 7.0149747 0.0023089939 3.188282e-01 4.618135e-01 6 97270107 97270283 177 - 0.852 0.713 -0.555
ENSG00000146263 E038 7.0359102 0.0054763898 3.510358e-03 1.175561e-02 6 97270284 97272703 2420 - 0.723 1.106 1.459
ENSG00000146263 E039 70.0806608 0.0003769677 5.414263e-02 1.165030e-01 6 97272704 97272881 178 - 1.783 1.695 -0.300
ENSG00000146263 E040 46.5893259 0.0005034344 8.666746e-01 9.181911e-01 6 97272975 97273062 88 - 1.590 1.615 0.085
ENSG00000146263 E041 0.1817044 0.0419275831 9.332776e-02   6 97273063 97273105 43 - 0.000 0.229 11.930
ENSG00000146263 E042 36.7409920 0.0005903520 6.919785e-01 7.933236e-01 6 97278849 97278898 50 - 1.493 1.479 -0.048
ENSG00000146263 E043 58.2277768 0.0004383045 1.558104e-01 2.695149e-01 6 97281237 97281362 126 - 1.698 1.629 -0.233
ENSG00000146263 E044 82.1360350 0.0003741410 1.855192e-01 3.081545e-01 6 97282314 97282553 240 - 1.843 1.792 -0.169
ENSG00000146263 E045 0.8877605 0.3982834729 4.552050e-01 5.957337e-01 6 97282987 97283044 58 - 0.283 0.000 -10.853
ENSG00000146263 E046 4.9290880 0.0395759923 3.636935e-01 5.081094e-01 6 97283045 97283077 33 - 0.735 0.575 -0.686
ENSG00000146263 E047 6.1188472 0.0601251803 3.464530e-01 4.905850e-01 6 97283078 97283095 18 - 0.813 0.646 -0.686
ENSG00000146263 E048 40.2760731 0.0005626998 6.820131e-02 1.403872e-01 6 97283096 97283221 126 - 1.552 1.437 -0.397