ENSG00000146247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275034 ENSG00000146247 HEK293_OSMI2_2hA HEK293_TMG_2hB PHIP protein_coding protein_coding 6.710558 0.8771063 11.04859 0.06536924 0.05868825 3.639917 4.205097 0.862397761 7.107045 0.053290061 0.2838935 3.028220 0.785550 0.9850 0.6431667 -0.3418333 2.550070e-07 2.55007e-07 FALSE TRUE
MSTRG.28553.2 ENSG00000146247 HEK293_OSMI2_2hA HEK293_TMG_2hB PHIP protein_coding   6.710558 0.8771063 11.04859 0.06536924 0.05868825 3.639917 2.196396 0.006662794 3.308008 0.006662794 0.3525544 7.637543 0.178875 0.0066 0.2994667 0.2928667 4.353555e-06 2.55007e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146247 E001 588.19481 0.0022979328 3.127170e-29 4.912379e-27 6 78934419 78940545 6127 - 2.487 2.824 1.120
ENSG00000146247 E002 131.14425 0.0003773435 3.752388e-04 1.678263e-03 6 78940546 78941330 785 - 1.894 1.759 -0.456
ENSG00000146247 E003 63.76813 0.0005409754 1.656708e-04 8.165528e-04 6 78945300 78945497 198 - 1.596 1.328 -0.919
ENSG00000146247 E004 64.88299 0.0004200775 1.724952e-05 1.085671e-04 6 78946001 78946260 260 - 1.605 1.280 -1.121
ENSG00000146247 E005 46.05749 0.0005470310 6.056573e-04 2.553977e-03 6 78946711 78946874 164 - 1.458 1.162 -1.033
ENSG00000146247 E006 58.33828 0.0335339838 1.644108e-03 6.102018e-03 6 78947623 78947775 153 - 1.560 1.203 -1.241
ENSG00000146247 E007 58.04095 0.0031496155 8.027934e-05 4.292115e-04 6 78954814 78954963 150 - 1.557 1.226 -1.147
ENSG00000146247 E008 32.09776 0.0023388268 1.133618e-03 4.416419e-03 6 78955232 78955282 51 - 1.312 0.949 -1.307
ENSG00000146247 E009 25.72866 0.0049269873 1.710578e-02 4.517625e-02 6 78955613 78955682 70 - 1.217 0.949 -0.972
ENSG00000146247 E010 19.88908 0.0106873578 2.535969e-03 8.871255e-03 6 78955683 78958474 2792 - 1.121 0.642 -1.851
ENSG00000146247 E011 37.66387 0.0008507899 6.617555e-07 5.713590e-06 6 78958475 78958600 126 - 1.389 0.741 -2.379
ENSG00000146247 E012 44.02837 0.0005000644 5.155013e-05 2.894934e-04 6 78961690 78961810 121 - 1.445 1.047 -1.403
ENSG00000146247 E013 48.79409 0.0015379814 5.811074e-04 2.463834e-03 6 78963097 78963252 156 - 1.484 1.195 -1.008
ENSG00000146247 E014 34.22795 0.0070637307 1.284241e-02 3.554615e-02 6 78965703 78965764 62 - 1.334 1.089 -0.868
ENSG00000146247 E015 38.43039 0.0005647165 5.589509e-04 2.380918e-03 6 78965945 78966056 112 - 1.387 1.047 -1.204
ENSG00000146247 E016 35.02150 0.0006799572 2.292166e-03 8.126127e-03 6 78969835 78969917 83 - 1.347 1.047 -1.064
ENSG00000146247 E017 40.60316 0.0005436382 4.204570e-03 1.371553e-02 6 78970049 78970173 125 - 1.405 1.162 -0.851
ENSG00000146247 E018 33.49927 0.0011354800 1.020227e-02 2.926385e-02 6 78970781 78970888 108 - 1.326 1.089 -0.840
ENSG00000146247 E019 31.67465 0.0006093235 8.035738e-03 2.387021e-02 6 78978592 78978711 120 - 1.304 1.047 -0.916
ENSG00000146247 E020 51.63036 0.0108515882 2.261481e-03 8.034685e-03 6 78982886 78983117 232 - 1.506 1.227 -0.969
ENSG00000146247 E021 35.69153 0.0033300082 5.590425e-02 1.195239e-01 6 78985352 78985428 77 - 1.343 1.196 -0.518
ENSG00000146247 E022 45.81529 0.0004923594 1.488283e-02 4.022753e-02 6 78988209 78988349 141 - 1.451 1.280 -0.593
ENSG00000146247 E023 46.35477 0.0032796505 8.749890e-03 2.566007e-02 6 78990868 78990982 115 - 1.457 1.254 -0.705
ENSG00000146247 E024 24.27920 0.0007796400 5.488920e-02 1.178035e-01 6 78990983 78990985 3 - 1.189 1.001 -0.680
ENSG00000146247 E025 57.53470 0.0011800444 4.996494e-05 2.816253e-04 6 78997414 78997597 184 - 1.555 1.225 -1.145
ENSG00000146247 E026 48.35619 0.0004510369 2.495266e-05 1.513384e-04 6 78998254 78998391 138 - 1.484 1.089 -1.386
ENSG00000146247 E027 51.59744 0.0004930385 6.641304e-05 3.627642e-04 6 79001899 79002124 226 - 1.508 1.162 -1.203
ENSG00000146247 E028 29.14131 0.0012249795 6.482249e-05 3.550077e-04 6 79003730 79003858 129 - 1.279 0.741 -1.999
ENSG00000146247 E029 33.67052 0.0094441179 3.874429e-06 2.827859e-05 6 79015082 79015216 135 - 1.343 0.642 -2.635
ENSG00000146247 E030 42.98019 0.0005643822 1.275892e-06 1.036064e-05 6 79015630 79015783 154 - 1.440 0.890 -1.973
ENSG00000146247 E031 38.98681 0.0024196707 1.634275e-03 6.070993e-03 6 79016544 79016642 99 - 1.390 1.089 -1.062
ENSG00000146247 E032 24.82369 0.0106770479 4.024167e-03 1.320961e-02 6 79017346 79017386 41 - 1.209 0.822 -1.429
ENSG00000146247 E033 29.55226 0.0086249111 1.678652e-03 6.214763e-03 6 79017483 79017583 101 - 1.281 0.890 -1.420
ENSG00000146247 E034 24.34445 0.0007461426 6.710275e-04 2.792526e-03 6 79019089 79019159 71 - 1.205 0.741 -1.736
ENSG00000146247 E035 29.53457 0.0006736382 7.173868e-03 2.167538e-02 6 79025519 79025619 101 - 1.277 1.001 -0.991
ENSG00000146247 E036 50.71513 0.0004234255 5.701045e-04 2.421899e-03 6 79025943 79026164 222 - 1.500 1.225 -0.955
ENSG00000146247 E037 45.35340 0.0004711848 7.219046e-06 4.954630e-05 6 79042843 79043003 161 - 1.461 1.001 -1.628
ENSG00000146247 E038 28.56942 0.0006959547 6.174998e-01 7.352851e-01 6 79060478 79060576 99 - 1.241 1.253 0.042
ENSG00000146247 E039 29.75777 0.0006460102 8.725928e-01 9.220508e-01 6 79060668 79060818 151 - 1.255 1.305 0.174
ENSG00000146247 E040 31.94681 0.0119048152 1.240060e-23 1.180531e-21 6 79077448 79077507 60 - 1.085 1.973 3.057
ENSG00000146247 E041 28.74666 0.0007668307 5.916870e-30 9.946170e-28 6 79077700 79077729 30 - 1.043 1.921 3.035
ENSG00000146247 E042 35.56411 0.0006413934 4.155612e-40 1.444529e-37 6 79077855 79077913 59 - 1.115 2.029 3.141
ENSG00000146247 E043 45.33847 0.0005097799 7.548879e-48 4.097743e-45 6 79078029 79078411 383 - 1.220 2.120 3.069