ENSG00000146122

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274867 ENSG00000146122 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM2 protein_coding protein_coding 3.254377 5.171107 2.505799 0.5795045 0.09397029 -1.042244 2.5114301 3.82217914 1.9593582 0.286308771 0.09086109 -0.9604395 0.78589167 0.74490000 0.78153333 0.03663333 0.7899799 0.0220355 FALSE TRUE
ENST00000405961 ENSG00000146122 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM2 protein_coding protein_coding 3.254377 5.171107 2.505799 0.5795045 0.09397029 -1.042244 0.3264821 0.81144134 0.1682999 0.048648467 0.08551177 -2.2038520 0.07878333 0.15983333 0.06473333 -0.09510000 0.3081574 0.0220355 FALSE TRUE
ENST00000491083 ENSG00000146122 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM2 protein_coding retained_intron 3.254377 5.171107 2.505799 0.5795045 0.09397029 -1.042244 0.0917779 0.09464095 0.1738205 0.007868504 0.01373528 0.8128503 0.03291667 0.01886667 0.06920000 0.05033333 0.0220355 0.0220355 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146122 E001 1.0684302 0.0118095052 3.674448e-01 5.118253e-01 6 39792298 39792373 76 + 0.164 0.333 1.327
ENSG00000146122 E002 1.2167234 0.0111457090 2.594208e-01 3.968067e-01 6 39792374 39792375 2 + 0.164 0.377 1.589
ENSG00000146122 E003 1.2167234 0.0111457090 2.594208e-01 3.968067e-01 6 39792376 39792378 3 + 0.164 0.377 1.589
ENSG00000146122 E004 3.5666230 0.0045792702 6.704549e-02 1.384563e-01 6 39792379 39792395 17 + 0.376 0.692 1.508
ENSG00000146122 E005 10.5611960 0.0017184831 8.309620e-02 1.644073e-01 6 39792396 39792465 70 + 0.871 1.073 0.752
ENSG00000146122 E006 0.0000000       6 39792997 39793017 21 +      
ENSG00000146122 E007 0.0000000       6 39793018 39793143 126 +      
ENSG00000146122 E008 1.1382859 0.0393023127 4.033200e-02 9.163909e-02 6 39848566 39848936 371 + 0.000 0.415 12.354
ENSG00000146122 E009 36.7987688 0.0007338812 2.085059e-01 3.366815e-01 6 39856247 39856470 224 + 1.476 1.559 0.285
ENSG00000146122 E010 28.9153816 0.0007538171 5.808449e-01 7.055286e-01 6 39860928 39861017 90 + 1.404 1.447 0.147
ENSG00000146122 E011 10.0966207 0.0046084580 1.899840e-02 4.932965e-02 6 39861018 39861122 105 + 0.782 1.073 1.100
ENSG00000146122 E012 1.3275530 0.0141850452 2.590172e-01 3.963813e-01 6 39861123 39861328 206 + 0.164 0.378 1.593
ENSG00000146122 E013 0.8544736 0.0156537961 7.523267e-01 8.385619e-01 6 39861329 39862819 1491 + 0.283 0.228 -0.410
ENSG00000146122 E014 14.8425929 0.0012442606 3.831448e-02 8.793888e-02 6 39864433 39864507 75 + 1.277 1.098 -0.637
ENSG00000146122 E015 17.3137914 0.0014636543 1.439310e-01 2.533682e-01 6 39864980 39865074 95 + 1.298 1.178 -0.421
ENSG00000146122 E016 0.0000000       6 39867313 39867509 197 +      
ENSG00000146122 E017 33.6515329 0.0244901891 1.321178e-01 2.370561e-01 6 39867510 39867843 334 + 1.587 1.451 -0.466
ENSG00000146122 E018 0.0000000       6 39867844 39868822 979 +      
ENSG00000146122 E019 16.6546132 0.0164502453 3.079932e-01 4.502280e-01 6 39868823 39868933 111 + 1.266 1.169 -0.343
ENSG00000146122 E020 14.7914514 0.0017524888 6.510762e-02 1.352090e-01 6 39870340 39870443 104 + 1.266 1.106 -0.571
ENSG00000146122 E021 13.8250165 0.0095765884 5.723531e-02 1.218677e-01 6 39871506 39871572 67 + 1.255 1.073 -0.650
ENSG00000146122 E022 17.6903218 0.0194929635 2.449374e-02 6.083919e-02 6 39873238 39873355 118 + 1.380 1.162 -0.764
ENSG00000146122 E023 18.9299254 0.0170677154 5.255274e-03 1.662485e-02 6 39875330 39875468 139 + 1.434 1.170 -0.926
ENSG00000146122 E024 13.1177646 0.0053859526 9.946661e-02 1.896675e-01 6 39878203 39878261 59 + 1.221 1.064 -0.560
ENSG00000146122 E025 20.9045107 0.0065499985 1.407742e-02 3.839899e-02 6 39878404 39878588 185 + 1.434 1.234 -0.699
ENSG00000146122 E026 21.8162887 0.0009402164 1.197786e-01 2.196680e-01 6 39879178 39879477 300 + 1.396 1.283 -0.392
ENSG00000146122 E027 4.4629323 0.0112680497 1.623601e-01 2.782076e-01 6 39879478 39880017 540 + 0.843 0.648 -0.793
ENSG00000146122 E028 19.5462047 0.0323417354 8.601566e-01 9.137886e-01 6 39883962 39884069 108 + 1.256 1.283 0.095
ENSG00000146122 E029 0.9191074 0.0131854358 9.786554e-02 1.872591e-01 6 39885924 39886420 497 + 0.453 0.165 -1.996
ENSG00000146122 E030 0.7707125 0.0149556748 7.497389e-01 8.366021e-01 6 39886421 39886447 27 + 0.283 0.228 -0.413
ENSG00000146122 E031 1.1103636 0.0116531780 4.131163e-02 9.345360e-02 6 39886448 39887404 957 + 0.518 0.165 -2.317
ENSG00000146122 E032 0.3634088 0.2602113238 5.401821e-01   6 39887405 39887485 81 + 0.000 0.165 10.120
ENSG00000146122 E033 24.7105353 0.0421353893 5.892127e-01 7.122775e-01 6 39887486 39887592 107 + 1.405 1.352 -0.183
ENSG00000146122 E034 0.7019140 0.0174746817 4.931636e-01 6.302039e-01 6 39887593 39888678 1086 + 0.283 0.165 -0.994
ENSG00000146122 E035 23.0562669 0.0098664303 3.383888e-01 4.822630e-01 6 39888679 39888763 85 + 1.388 1.312 -0.266
ENSG00000146122 E036 21.5317415 0.0114200732 3.994658e-01 5.432160e-01 6 39891341 39891447 107 + 1.354 1.282 -0.252
ENSG00000146122 E037 14.4923551 0.0491004016 4.243429e-01 5.673282e-01 6 39891634 39891722 89 + 1.209 1.110 -0.351
ENSG00000146122 E038 21.2640640 0.0216194798 2.134006e-01 3.425384e-01 6 39896812 39896980 169 + 1.388 1.262 -0.439
ENSG00000146122 E039 26.1181540 0.0051722799 1.741043e-01 2.934958e-01 6 39897175 39897282 108 + 1.463 1.364 -0.341
ENSG00000146122 E040 23.3638053 0.0123449253 4.539784e-01 5.946778e-01 6 39898877 39898937 61 + 1.396 1.338 -0.203
ENSG00000146122 E041 13.2403461 0.0103104763 7.678820e-01 8.500217e-01 6 39900077 39900079 3 + 1.097 1.134 0.134
ENSG00000146122 E042 29.0281397 0.0006770735 5.247143e-01 6.581651e-01 6 39900080 39900208 129 + 1.463 1.425 -0.132
ENSG00000146122 E043 29.2847925 0.0012059768 7.194474e-01 8.142783e-01 6 39901302 39901472 171 + 1.449 1.429 -0.069
ENSG00000146122 E044 31.2582408 0.0008708259 2.834068e-01 4.235007e-01 6 39901813 39902079 267 + 1.515 1.450 -0.221
ENSG00000146122 E045 69.9335360 0.0057156564 8.220584e-01 8.877967e-01 6 39902080 39902759 680 + 1.818 1.814 -0.016
ENSG00000146122 E046 172.4596558 0.0020977427 2.603654e-04 1.218243e-03 6 39902760 39904070 1311 + 2.107 2.232 0.420
ENSG00000146122 E047 104.7398573 0.0052569509 1.278730e-10 2.217406e-09 6 39904071 39904877 807 + 1.720 2.058 1.139