ENSG00000146094

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000500323 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding retained_intron 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 0.8174477 0.3550887 0.9706746 0.04594237 0.03203721 1.42552758 0.07828333 0.05433333 0.085433333 0.031100000 0.37901837 0.0432051 FALSE TRUE
ENST00000501403 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding protein_coding 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 0.7035060 0.4148487 0.5321997 0.08158796 0.01791269 0.35187526 0.06553333 0.05816667 0.047400000 -0.010766667 0.79386971 0.0432051 FALSE TRUE
ENST00000502380 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding retained_intron 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 1.0363080 0.6022695 1.0800158 0.22945989 0.16441040 0.83211031 0.09413750 0.07676667 0.093033333 0.016266667 0.78746330 0.0432051 FALSE FALSE
ENST00000509310 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding protein_coding 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 0.3614572 0.6805620 0.1316808 0.20939154 0.13168078 -2.28512686 0.04040833 0.10173333 0.009966667 -0.091766667 0.08343099 0.0432051 TRUE FALSE
ENST00000510389 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding protein_coding 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 3.1878195 1.5545941 3.4428083 0.80160336 0.39879683 1.14198181 0.29384167 0.18786667 0.298533333 0.110666667 0.72385707 0.0432051 TRUE FALSE
ENST00000510898 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding protein_coding 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 2.7793630 2.5802002 2.7466992 0.38794762 0.24411249 0.08987825 0.28622917 0.35983333 0.241633333 -0.118200000 0.04320510 0.0432051 FALSE TRUE
ENST00000512660 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding retained_intron 10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 0.4064220 0.1561936 1.1972306 0.15619363 0.20171262 2.86076428 0.03870000 0.03010000 0.104100000 0.074000000 0.18487829 0.0432051 FALSE FALSE
MSTRG.27394.3 ENSG00000146094 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK3 protein_coding   10.28606 7.24442 11.47643 1.234838 1.02033 0.6629988 0.5405127 0.6045687 1.0750878 0.13061018 0.03086321 0.82016543 0.05630000 0.08970000 0.095466667 0.005766667 0.93122193 0.0432051 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146094 E001 0.6537541 0.4816272320 0.910865374 0.94736540 5 177501904 177501906 3 - 0.203 0.234 0.265
ENSG00000146094 E002 37.4549873 0.0035379254 0.008400297 0.02478949 5 177501907 177502087 181 - 1.485 1.654 0.578
ENSG00000146094 E003 165.8385742 0.0056890529 0.132194088 0.23716144 5 177502088 177503047 960 - 2.185 2.253 0.229
ENSG00000146094 E004 36.4540295 0.0025141529 0.159792109 0.27483895 5 177503048 177503216 169 - 1.526 1.614 0.301
ENSG00000146094 E005 20.5928526 0.0173865773 0.610147498 0.72949463 5 177503217 177503254 38 - 1.310 1.361 0.179
ENSG00000146094 E006 24.6138976 0.0090200579 0.346098618 0.49025979 5 177503255 177503318 64 - 1.369 1.446 0.267
ENSG00000146094 E007 20.9333059 0.0112403930 0.498232570 0.63472487 5 177503319 177503374 56 - 1.310 1.369 0.206
ENSG00000146094 E008 17.3584331 0.0144225845 0.675071774 0.78045197 5 177503375 177503392 18 - 1.233 1.277 0.152
ENSG00000146094 E009 15.6695452 0.0171561466 0.698440165 0.79840578 5 177503393 177503427 35 - 1.194 1.233 0.140
ENSG00000146094 E010 44.4655826 0.0005561214 0.623115187 0.73978619 5 177503428 177503749 322 - 1.635 1.663 0.098
ENSG00000146094 E011 16.5473493 0.0010760296 0.088122209 0.17226796 5 177503750 177503783 34 - 1.160 1.304 0.511
ENSG00000146094 E012 41.3900905 0.0005435953 0.082676744 0.16373812 5 177503784 177504060 277 - 1.566 1.663 0.330
ENSG00000146094 E013 38.9649486 0.0077311829 0.727159210 0.81996935 5 177504061 177504353 293 - 1.573 1.608 0.119
ENSG00000146094 E014 18.9458199 0.0010601374 0.904201664 0.94302847 5 177504354 177504468 115 - 1.284 1.297 0.046
ENSG00000146094 E015 21.8710900 0.0010328803 0.444162327 0.58574108 5 177504469 177504660 192 - 1.329 1.387 0.204
ENSG00000146094 E016 9.6536667 0.0209974545 0.667526225 0.77474781 5 177504743 177504746 4 - 1.059 1.007 -0.188
ENSG00000146094 E017 27.7770108 0.0008050037 0.323936920 0.46727690 5 177504747 177504915 169 - 1.421 1.488 0.231
ENSG00000146094 E018 12.4259607 0.0014322225 0.978858880 0.99084121 5 177505011 177505012 2 - 1.122 1.128 0.020
ENSG00000146094 E019 14.7134323 0.0020270282 0.513523066 0.64833777 5 177505013 177505050 38 - 1.160 1.220 0.216
ENSG00000146094 E020 20.5894937 0.0065762860 0.686541964 0.78904678 5 177505051 177505110 60 - 1.310 1.349 0.136
ENSG00000146094 E021 35.2538106 0.0027429169 0.705562153 0.80389861 5 177508237 177508477 241 - 1.559 1.542 -0.061
ENSG00000146094 E022 15.3169048 0.0160028118 0.361278007 0.50567817 5 177508478 177508542 65 - 1.249 1.162 -0.307
ENSG00000146094 E023 11.0778764 0.0016323723 0.005408706 0.01703776 5 177508543 177508783 241 - 1.202 0.927 -1.004
ENSG00000146094 E024 17.5673308 0.0011008506 0.041209319 0.09326447 5 177508784 177509165 382 - 1.335 1.171 -0.575
ENSG00000146094 E025 21.1013193 0.0016597492 0.006220303 0.01919435 5 177509166 177509474 309 - 1.426 1.221 -0.718
ENSG00000146094 E026 16.4111515 0.0012641884 0.015176491 0.04088827 5 177509475 177509501 27 - 1.329 1.127 -0.711
ENSG00000146094 E027 22.6395800 0.0141746088 0.134980057 0.24106836 5 177509502 177509575 74 - 1.422 1.295 -0.441
ENSG00000146094 E028 12.6832321 0.0518956805 0.434480369 0.57685004 5 177509576 177509584 9 - 1.159 1.082 -0.278
ENSG00000146094 E029 12.8369376 0.0467552799 0.373692840 0.51810182 5 177509585 177509595 11 - 1.168 1.081 -0.314
ENSG00000146094 E030 18.9032501 0.0185688608 0.224014443 0.35520828 5 177509596 177509657 62 - 1.341 1.227 -0.398
ENSG00000146094 E031 9.2814762 0.0020457493 0.081588287 0.16203935 5 177509758 177509801 44 - 1.092 0.908 -0.678
ENSG00000146094 E032 12.9424641 0.0015682505 0.040983489 0.09285098 5 177509802 177509935 134 - 1.226 1.039 -0.673
ENSG00000146094 E033 16.9486418 0.0012378137 0.671488117 0.77768994 5 177510150 177510259 110 - 1.226 1.265 0.135
ENSG00000146094 E034 27.2660751 0.0007260608 0.073660027 0.14938682 5 177510260 177510542 283 - 1.502 1.388 -0.394
ENSG00000146094 E035 16.0235639 0.0011506027 0.273419323 0.41245746 5 177510543 177510579 37 - 1.270 1.181 -0.313
ENSG00000146094 E036 11.4151708 0.0061554473 0.175344437 0.29511824 5 177510580 177510581 2 - 1.160 1.024 -0.491
ENSG00000146094 E037 59.1584667 0.0021730959 0.360913416 0.50529105 5 177510920 177511283 364 - 1.796 1.754 -0.142