ENSG00000146083

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274811 ENSG00000146083 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF44 protein_coding protein_coding 18.44334 14.32179 15.84559 1.631047 0.6310939 0.145773 7.813633 8.9452198 5.303909 1.00479517 0.26203024 -0.7529553 0.43808750 0.62476667 0.33693333 -0.28783333 4.494358e-09 4.494358e-09 FALSE TRUE
ENST00000504434 ENSG00000146083 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF44 protein_coding retained_intron 18.44334 14.32179 15.84559 1.631047 0.6310939 0.145773 1.123215 0.3417900 1.165603 0.09725824 0.08403573 1.7406139 0.05704167 0.02303333 0.07363333 0.05060000 1.492858e-04 4.494358e-09   FALSE
ENST00000508478 ENSG00000146083 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF44 protein_coding retained_intron 18.44334 14.32179 15.84559 1.631047 0.6310939 0.145773 1.998291 0.5229823 2.087384 0.14911456 0.05924357 1.9764318 0.10387500 0.03630000 0.13250000 0.09620000 3.202530e-05 4.494358e-09   FALSE
ENST00000515051 ENSG00000146083 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF44 protein_coding retained_intron 18.44334 14.32179 15.84559 1.631047 0.6310939 0.145773 1.255162 0.4454976 1.534979 0.09215741 0.39895253 1.7620723 0.06439583 0.03356667 0.09520000 0.06163333 1.125865e-01 4.494358e-09 FALSE TRUE
MSTRG.27361.2 ENSG00000146083 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF44 protein_coding   18.44334 14.32179 15.84559 1.631047 0.6310939 0.145773 4.496240 3.1608557 4.248773 0.36465621 0.50421085 0.4255656 0.24637917 0.22056667 0.26640000 0.04583333 4.434873e-01 4.494358e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146083 E001 179.391138 0.0049877245 1.863688e-14 5.896295e-13 5 176526712 176527267 556 - 2.007 2.353 1.158
ENSG00000146083 E002 676.529278 0.0004247922 1.085220e-08 1.329142e-07 5 176527268 176528736 1469 - 2.760 2.851 0.305
ENSG00000146083 E003 113.245356 0.0008380814 4.589141e-01 5.991517e-01 5 176528737 176528938 202 - 2.051 2.038 -0.043
ENSG00000146083 E004 40.739947 0.0015021235 9.521186e-01 9.740209e-01 5 176528939 176528957 19 - 1.603 1.612 0.031
ENSG00000146083 E005 97.401748 0.0003551320 1.535863e-01 2.665466e-01 5 176528958 176529042 85 - 2.003 1.965 -0.130
ENSG00000146083 E006 89.858056 0.0003095335 1.528066e-01 2.654702e-01 5 176529043 176529077 35 - 1.969 1.929 -0.137
ENSG00000146083 E007 68.991168 0.0005553272 5.814248e-01 7.059532e-01 5 176529078 176529090 13 - 1.841 1.829 -0.038
ENSG00000146083 E008 11.066491 0.0466979201 1.198480e-04 6.132634e-04 5 176529091 176529287 197 - 1.320 0.773 -2.013
ENSG00000146083 E009 98.615003 0.0003090189 8.763779e-02 1.715493e-01 5 176529288 176529387 100 - 2.014 1.966 -0.162
ENSG00000146083 E010 3.955688 0.0041288705 1.374953e-03 5.225185e-03 5 176529488 176529522 35 - 0.896 0.441 -1.966
ENSG00000146083 E011 114.493829 0.0003809154 4.702999e-02 1.038776e-01 5 176529523 176529644 122 - 2.078 2.024 -0.179
ENSG00000146083 E012 9.502009 0.0017905253 2.285877e-07 2.167539e-06 5 176529645 176529730 86 - 1.255 0.708 -2.051
ENSG00000146083 E013 71.750944 0.0015712588 2.275747e-02 5.724556e-02 5 176529731 176529818 88 - 1.894 1.806 -0.297
ENSG00000146083 E014 18.437976 0.0013134486 7.727339e-15 2.585063e-13 5 176529819 176530081 263 - 1.544 0.905 -2.272
ENSG00000146083 E015 35.812884 0.0006235849 6.592065e-01 7.680722e-01 5 176530082 176530206 125 - 1.561 1.548 -0.047
ENSG00000146083 E016 37.420293 0.0005760393 1.319541e-01 2.368338e-01 5 176530582 176530743 162 - 1.614 1.540 -0.252
ENSG00000146083 E017 18.951116 0.0010254010 1.268392e-01 2.297477e-01 5 176530848 176530880 33 - 1.342 1.234 -0.379
ENSG00000146083 E018 14.506517 0.0014992340 2.776679e-01 4.172750e-01 5 176530881 176530936 56 - 1.219 1.134 -0.302
ENSG00000146083 E019 22.384347 0.0012341440 6.276550e-01 7.434174e-01 5 176530937 176531021 85 - 1.363 1.339 -0.083
ENSG00000146083 E020 68.848072 0.0011826105 7.149696e-01 8.110272e-01 5 176531463 176531630 168 - 1.832 1.828 -0.012
ENSG00000146083 E021 9.697028 0.0225355669 1.700247e-06 1.343237e-05 5 176531882 176532003 122 - 1.280 0.682 -2.247
ENSG00000146083 E022 64.032360 0.0026157144 1.365876e-01 2.433108e-01 5 176532004 176532098 95 - 1.836 1.776 -0.203
ENSG00000146083 E023 37.959979 0.0010460488 3.015960e-01 4.434143e-01 5 176532099 176532129 31 - 1.603 1.555 -0.162
ENSG00000146083 E024 14.451464 0.0018462134 8.660312e-02 1.699701e-01 5 176532130 176532132 3 - 1.246 1.105 -0.503
ENSG00000146083 E025 19.200680 0.0016217311 3.937436e-03 1.296557e-02 5 176532133 176532193 61 - 1.402 1.187 -0.753
ENSG00000146083 E026 8.342513 0.0021088176 8.062044e-06 5.469596e-05 5 176532194 176532365 172 - 1.179 0.682 -1.887
ENSG00000146083 E027 40.228167 0.0026765092 3.033417e-01 4.452508e-01 5 176532366 176532479 114 - 1.622 1.574 -0.161
ENSG00000146083 E028 15.289179 0.0276116520 7.455639e-01 8.335685e-01 5 176532480 176532516 37 - 1.147 1.214 0.240
ENSG00000146083 E029 4.512714 0.0715004307 6.994646e-01 7.991954e-01 5 176535996 176536462 467 - 0.696 0.772 0.310
ENSG00000146083 E030 4.691977 0.0449059603 5.086466e-01 6.440291e-01 5 176536463 176536641 179 - 0.665 0.780 0.475
ENSG00000146083 E031 25.892143 0.0009845762 1.960284e-01 3.212514e-01 5 176536940 176537402 463 - 1.454 1.378 -0.264
ENSG00000146083 E032 9.787885 0.0506132501 9.230141e-01 9.554479e-01 5 176537731 176537795 65 - 1.002 1.024 0.079
ENSG00000146083 E033 10.158682 0.0023786224 9.094736e-01 9.464946e-01 5 176537796 176538030 235 - 1.017 1.040 0.085
ENSG00000146083 E034 1.102977 0.0117314641 2.361816e-02 5.902421e-02 5 176543261 176543323 63 - 0.501 0.112 -2.887