ENSG00000146063

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315073 ENSG00000146063 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM41 protein_coding protein_coding 38.37811 58.50061 24.98387 4.102359 0.5481393 -1.227124 27.973664 46.156494 16.66954454 3.3777472 0.03187476 -1.4687663 0.70912500 0.78870000 0.667900000 -0.12080000 3.090311e-04 6.046676e-45 FALSE TRUE
ENST00000351937 ENSG00000146063 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM41 protein_coding protein_coding 38.37811 58.50061 24.98387 4.102359 0.5481393 -1.227124 1.667572 0.000000 3.16776645 0.0000000 0.25220391 8.3118693 0.06255000 0.00000000 0.126866667 0.12686667 6.046676e-45 6.046676e-45 FALSE TRUE
ENST00000508930 ENSG00000146063 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM41 protein_coding retained_intron 38.37811 58.50061 24.98387 4.102359 0.5481393 -1.227124 3.116247 2.602103 2.09936701 0.4231508 0.36730553 -0.3084014 0.09047083 0.04386667 0.083500000 0.03963333 4.978843e-02 6.046676e-45 TRUE TRUE
ENST00000515223 ENSG00000146063 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM41 protein_coding retained_intron 38.37811 58.50061 24.98387 4.102359 0.5481393 -1.227124 2.043317 1.220126 1.47312550 0.1009558 0.10397186 0.2698341 0.06037083 0.02086667 0.058833333 0.03796667 1.261806e-07 6.046676e-45 FALSE TRUE
MSTRG.27486.10 ENSG00000146063 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM41 protein_coding   38.37811 58.50061 24.98387 4.102359 0.5481393 -1.227124 2.051955 5.475945 0.07377824 0.6816606 0.07377824 -6.0330208 0.03705833 0.09476667 0.002933333 -0.09183333 6.131062e-04 6.046676e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146063 E001 0.2955422 0.0297149522 5.013146e-01   5 181222499 181222781 283 + 0.179 0.082 -1.294
ENSG00000146063 E002 3.0550228 0.0059156826 9.345454e-01 9.627866e-01 5 181222874 181223280 407 + 0.549 0.544 -0.024
ENSG00000146063 E003 5.6733220 0.0029092505 5.882209e-01 7.114418e-01 5 181223281 181223289 9 + 0.705 0.793 0.354
ENSG00000146063 E004 751.9969502 0.0023703670 5.719223e-02 1.217910e-01 5 181223290 181224057 768 + 2.837 2.806 -0.104
ENSG00000146063 E005 244.3584563 0.0014722368 1.038124e-01 1.963181e-01 5 181224058 181224165 108 + 2.351 2.315 -0.121
ENSG00000146063 E006 223.5597636 0.0008866251 3.239997e-07 2.977193e-06 5 181224166 181224293 128 + 2.381 2.247 -0.446
ENSG00000146063 E007 235.5117189 0.0001657581 4.823231e-04 2.092486e-03 5 181224294 181224380 87 + 2.365 2.288 -0.257
ENSG00000146063 E008 691.8371654 0.0001512425 7.018598e-04 2.905772e-03 5 181224381 181224690 310 + 2.804 2.765 -0.131
ENSG00000146063 E009 541.1486014 0.0001309069 6.524571e-06 4.525042e-05 5 181224691 181224812 122 + 2.716 2.652 -0.214
ENSG00000146063 E010 12.2163345 0.0096505886 5.992650e-01 7.207089e-01 5 181224813 181230743 5931 + 1.104 1.056 -0.172
ENSG00000146063 E011 465.4968637 0.0001444203 5.504567e-03 1.729938e-02 5 181230744 181230839 96 + 2.631 2.592 -0.130
ENSG00000146063 E012 35.3598254 0.0005766769 2.610156e-19 1.542859e-17 5 181230840 181232658 1819 + 1.814 1.295 -1.774
ENSG00000146063 E013 518.0375956 0.0001275693 6.276552e-01 7.434174e-01 5 181232659 181232889 231 + 2.633 2.654 0.069
ENSG00000146063 E014 35.5121322 0.0010326083 3.464614e-16 1.391184e-14 5 181232890 181233408 519 + 1.800 1.326 -1.620
ENSG00000146063 E015 16.7954730 0.0121331156 1.156829e-03 4.494531e-03 5 181233409 181233412 4 + 1.388 1.084 -1.073
ENSG00000146063 E016 197.3734852 0.0002097812 6.018667e-01 7.229292e-01 5 181233413 181233435 23 + 2.233 2.230 -0.010
ENSG00000146063 E017 56.1986363 0.0004492251 1.800831e-08 2.116652e-07 5 181233436 181233635 200 + 1.871 1.606 -0.896
ENSG00000146063 E018 304.1063904 0.0001703247 2.567799e-02 6.327466e-02 5 181233636 181233705 70 + 2.447 2.408 -0.130
ENSG00000146063 E019 340.2656657 0.0001543877 2.478457e-01 3.833982e-01 5 181233706 181233763 58 + 2.476 2.463 -0.044
ENSG00000146063 E020 45.9463342 0.0004942235 2.782407e-09 3.801245e-08 5 181233764 181234124 361 + 1.814 1.508 -1.038
ENSG00000146063 E021 21.0116744 0.0026158742 4.775245e-03 1.530410e-02 5 181234125 181234173 49 + 1.431 1.215 -0.752
ENSG00000146063 E022 405.1597317 0.0007038704 3.231578e-01 4.664940e-01 5 181234174 181234349 176 + 2.550 2.541 -0.029
ENSG00000146063 E023 23.1519836 0.0008515502 6.170694e-01 7.349504e-01 5 181234350 181234355 6 + 1.274 1.327 0.182
ENSG00000146063 E024 736.2740316 0.0001065376 1.087469e-07 1.097240e-06 5 181234356 181234931 576 + 2.730 2.824 0.310
ENSG00000146063 E025 356.2386174 0.0002189369 1.506331e-03 5.656712e-03 5 181234932 181234995 64 + 2.423 2.507 0.278
ENSG00000146063 E026 340.0969192 0.0002431282 2.940979e-04 1.355884e-03 5 181234996 181235079 84 + 2.395 2.491 0.320
ENSG00000146063 E027 577.9049926 0.0007982120 2.578965e-09 3.542592e-08 5 181235080 181235353 274 + 2.590 2.732 0.473
ENSG00000146063 E028 839.3085448 0.0030770148 1.386730e-13 3.861138e-12 5 181235354 181236126 773 + 2.678 2.911 0.774