ENSG00000145908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274599 ENSG00000145908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF300 protein_coding protein_coding 2.6881 0.8440304 4.563267 0.07599951 0.1422651 2.420866 1.11710173 0.35014706 1.9158390 0.226923416 0.30049043 2.41882903 0.36863750 0.3826000 0.42050000 0.0379000 0.91006584 0.02905422 FALSE TRUE
ENST00000394226 ENSG00000145908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF300 protein_coding protein_coding 2.6881 0.8440304 4.563267 0.07599951 0.1422651 2.420866 0.04751459 0.09171988 0.0000000 0.091719876 0.00000000 -3.34652970 0.05408333 0.1226333 0.00000000 -0.1226333 0.49660971 0.02905422 FALSE TRUE
ENST00000418587 ENSG00000145908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF300 protein_coding protein_coding 2.6881 0.8440304 4.563267 0.07599951 0.1422651 2.420866 0.28594494 0.19526524 0.2088009 0.195265245 0.03669660 0.09212897 0.16914167 0.2471667 0.04566667 -0.2015000 0.99030003 0.02905422 FALSE TRUE
ENST00000427179 ENSG00000145908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF300 protein_coding protein_coding 2.6881 0.8440304 4.563267 0.07599951 0.1422651 2.420866 1.10926465 0.20689825 2.3263798 0.006242507 0.28049161 3.42918451 0.35133750 0.2476333 0.50920000 0.2615667 0.02905422 0.02905422 FALSE FALSE
ENST00000446148 ENSG00000145908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF300 protein_coding protein_coding 2.6881 0.8440304 4.563267 0.07599951 0.1422651 2.420866 0.12827368 0.00000000 0.1122478 0.000000000 0.01156553 3.61173700 0.05680417 0.0000000 0.02460000 0.0246000 0.34240635 0.02905422 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145908 E001 0.000000       5 150894392 150894398 7 -      
ENSG00000145908 E002 175.921899 0.0005343913 6.088647e-14 1.784462e-12 5 150894399 150896969 2571 - 2.097 2.242 0.487
ENSG00000145908 E003 7.232356 0.0027065665 4.301389e-01 5.727844e-01 5 150896970 150896973 4 - 0.825 0.691 -0.539
ENSG00000145908 E004 35.058840 0.0138239337 2.501649e-02 6.190631e-02 5 150896974 150898057 1084 - 1.471 1.241 -0.800
ENSG00000145908 E005 4.742852 0.0239462361 4.063370e-01 5.499938e-01 5 150898058 150898061 4 - 0.692 0.524 -0.744
ENSG00000145908 E006 18.698532 0.0252054534 3.150899e-02 7.489785e-02 5 150898062 150898184 123 - 1.222 0.905 -1.154
ENSG00000145908 E007 19.295636 0.0029117674 2.842623e-03 9.802440e-03 5 150898428 150898554 127 - 1.240 0.861 -1.388
ENSG00000145908 E008 10.332557 0.0016802078 5.512231e-03 1.731887e-02 5 150903141 150903182 42 - 0.997 0.525 -1.928
ENSG00000145908 E009 1.476984 0.0089702229 1.565122e-01 2.704695e-01 5 150903329 150903383 55 - 0.372 0.001 -10.177
ENSG00000145908 E010 13.089740 0.0017080133 6.196218e-02 1.299216e-01 5 150903864 150903977 114 - 1.073 0.811 -0.983
ENSG00000145908 E011 11.814084 0.0015832488 2.079503e-02 5.315822e-02 5 150904704 150904983 280 - 1.042 0.691 -1.357