ENSG00000145868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296701 ENSG00000145868 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO38 protein_coding protein_coding 7.564249 2.343478 13.10583 0.1639191 0.2321977 2.478443 1.2760859 0.08700396 1.90482566 0.08700396 0.19451626 4.303026 0.11693333 0.0342000 0.145033333 0.1108333 1.275520e-01 7.79571e-09 FALSE TRUE
ENST00000340253 ENSG00000145868 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO38 protein_coding protein_coding 7.564249 2.343478 13.10583 0.1639191 0.2321977 2.478443 3.1621468 1.57074352 4.53984654 0.07230278 0.41880613 1.525215 0.47727083 0.6752000 0.347333333 -0.3278667 1.643495e-04 7.79571e-09 FALSE TRUE
ENST00000394370 ENSG00000145868 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO38 protein_coding protein_coding 7.564249 2.343478 13.10583 0.1639191 0.2321977 2.478443 0.8174598 0.19998969 0.87194230 0.19998969 0.11009984 2.070366 0.11022083 0.0810000 0.066300000 -0.0147000 6.778608e-01 7.79571e-09 FALSE TRUE
ENST00000505399 ENSG00000145868 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO38 protein_coding processed_transcript 7.564249 2.343478 13.10583 0.1639191 0.2321977 2.478443 0.1976210 0.24932152 0.03016445 0.16720438 0.03016445 -2.690751 0.04947500 0.1042333 0.002366667 -0.1018667 1.838193e-01 7.79571e-09 FALSE TRUE
ENST00000508485 ENSG00000145868 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXO38 protein_coding processed_transcript 7.564249 2.343478 13.10583 0.1639191 0.2321977 2.478443 0.5848438 0.00000000 2.57024933 0.00000000 0.39073037 8.011367 0.05064167 0.0000000 0.196300000 0.1963000 7.795710e-09 7.79571e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145868 E001 0.1515154 0.0428123010 1.000000e+00   5 148383935 148383951 17 + 0.070 0.000 -10.787
ENSG00000145868 E002 0.1515154 0.0428123010 1.000000e+00   5 148383952 148383957 6 + 0.070 0.000 -10.779
ENSG00000145868 E003 4.8800837 0.0032636818 1.449809e-01 2.548098e-01 5 148383958 148384001 44 + 0.769 0.535 -1.005
ENSG00000145868 E004 6.7956919 0.0026290473 1.334224e-01 2.388900e-01 5 148384002 148384008 7 + 0.882 0.667 -0.860
ENSG00000145868 E005 7.2417053 0.0025339649 8.671030e-02 1.701399e-01 5 148384009 148384009 1 + 0.911 0.667 -0.970
ENSG00000145868 E006 17.8543875 0.0010459144 5.049590e-04 2.178714e-03 5 148384010 148384039 30 + 1.285 0.919 -1.327
ENSG00000145868 E007 2.3648689 0.0067386419 8.086360e-01 8.784493e-01 5 148384764 148385106 343 + 0.490 0.451 -0.197
ENSG00000145868 E008 0.8126314 0.0150950374 9.259127e-01 9.573550e-01 5 148394712 148394713 2 + 0.230 0.206 -0.196
ENSG00000145868 E009 40.0451250 0.0034281075 2.247341e-03 7.990541e-03 5 148394714 148394904 191 + 1.601 1.382 -0.750
ENSG00000145868 E010 0.5869198 0.1711752733 4.007365e-01 5.444047e-01 5 148397619 148397676 58 + 0.229 0.000 -12.776
ENSG00000145868 E011 0.0000000       5 148398997 148398998 2 +      
ENSG00000145868 E012 18.4759895 0.0018716014 8.851650e-02 1.728568e-01 5 148398999 148399014 16 + 1.274 1.119 -0.550
ENSG00000145868 E013 34.2499637 0.0103210654 4.486993e-02 9.996323e-02 5 148399015 148399132 118 + 1.531 1.368 -0.562
ENSG00000145868 E014 0.0000000       5 148399133 148399537 405 +      
ENSG00000145868 E015 33.6900290 0.0006554753 1.324561e-01 2.374944e-01 5 148401982 148402145 164 + 1.510 1.413 -0.333
ENSG00000145868 E016 31.5754216 0.0009766084 1.410631e-01 2.494934e-01 5 148402348 148402513 166 + 1.481 1.382 -0.342
ENSG00000145868 E017 0.0000000       5 148402514 148402565 52 +      
ENSG00000145868 E018 0.1472490 0.0434777944 1.000000e+00   5 148404684 148404684 1 + 0.070 0.000 -10.779
ENSG00000145868 E019 37.8931404 0.0082771840 3.324831e-03 1.121997e-02 5 148404685 148404822 138 + 1.585 1.347 -0.818
ENSG00000145868 E020 41.7315937 0.0087607996 3.372632e-03 1.135784e-02 5 148406257 148406394 138 + 1.624 1.392 -0.795
ENSG00000145868 E021 33.0638721 0.0006611562 1.017760e-02 2.920149e-02 5 148409124 148409217 94 + 1.517 1.336 -0.626
ENSG00000145868 E022 0.0000000       5 148409218 148409220 3 +      
ENSG00000145868 E023 0.4439371 0.0215790397 5.192337e-01 6.533557e-01 5 148410238 148410485 248 + 0.183 0.000 -12.364
ENSG00000145868 E024 34.4226753 0.0006227310 2.939218e-02 7.075614e-02 5 148410635 148410765 131 + 1.528 1.382 -0.505
ENSG00000145868 E025 1.3996649 0.0096765512 3.799894e-01 5.242534e-01 5 148410766 148410868 103 + 0.379 0.206 -1.197
ENSG00000145868 E026 5.7756767 0.0446345725 9.986842e-05 5.212202e-04 5 148413240 148414135 896 + 0.892 0.000 -16.064
ENSG00000145868 E027 37.8788327 0.0011440259 1.489096e-02 4.024032e-02 5 148414136 148414306 171 + 1.573 1.413 -0.549
ENSG00000145868 E028 1.6283858 0.0332991682 3.950950e-02 9.012374e-02 5 148415360 148415387 28 + 0.465 0.000 -14.238
ENSG00000145868 E029 41.3350269 0.0012018475 6.957256e-03 2.111181e-02 5 148415928 148416070 143 + 1.614 1.443 -0.585
ENSG00000145868 E030 0.1515154 0.0428123010 1.000000e+00   5 148416637 148416688 52 + 0.070 0.000 -10.779
ENSG00000145868 E031 54.3536605 0.0004404414 1.625165e-03 6.041534e-03 5 148416994 148417204 211 + 1.725 1.552 -0.589
ENSG00000145868 E032 0.0000000       5 148417205 148417215 11 +      
ENSG00000145868 E033 0.0000000       5 148423749 148423997 249 +      
ENSG00000145868 E034 37.4566152 0.0005359788 2.102310e-02 5.363701e-02 5 148423998 148424117 120 + 1.563 1.414 -0.513
ENSG00000145868 E035 46.0629730 0.0010457969 2.838312e-01 4.240211e-01 5 148425522 148425701 180 + 1.630 1.574 -0.192
ENSG00000145868 E036 55.3621289 0.0004646470 1.909022e-02 4.953479e-02 5 148427213 148427622 410 + 1.657 1.786 0.437
ENSG00000145868 E037 30.6074841 0.0072453719 6.475751e-02 1.346473e-01 5 148427623 148427722 100 + 1.396 1.546 0.515
ENSG00000145868 E038 33.7770934 0.0006436718 4.173084e-03 1.363019e-02 5 148427723 148427947 225 + 1.428 1.620 0.659
ENSG00000145868 E039 1.8478513 0.4532310659 4.355604e-01 5.777837e-01 5 148433233 148433423 191 + 0.272 0.639 1.943
ENSG00000145868 E040 34.8380958 0.0054713243 5.945840e-02 1.257055e-01 5 148433424 148433524 101 + 1.458 1.600 0.486
ENSG00000145868 E041 26.2463696 0.0009189889 1.949049e-02 5.039119e-02 5 148433635 148433737 103 + 1.327 1.505 0.617
ENSG00000145868 E042 4.9304494 0.0034646864 1.339854e-03 5.109431e-03 5 148433738 148435058 1321 + 0.818 0.206 -3.198
ENSG00000145868 E043 46.1254547 0.0005194632 4.333118e-03 1.407741e-02 5 148438332 148438498 167 + 1.569 1.736 0.568
ENSG00000145868 E044 41.4570880 0.0029854098 1.345120e-03 5.126930e-03 5 148439647 148439792 146 + 1.510 1.716 0.702
ENSG00000145868 E045 0.7384352 0.0184795331 2.385480e-01 3.724520e-01 5 148440356 148440423 68 + 0.272 0.000 -13.100
ENSG00000145868 E046 34.7974067 0.0005995904 1.255091e-02 3.485338e-02 5 148440424 148440527 104 + 1.453 1.620 0.573
ENSG00000145868 E047 45.8202783 0.0063896088 4.075677e-03 1.335556e-02 5 148441124 148441237 114 + 1.559 1.760 0.685
ENSG00000145868 E048 2.3292531 0.2104297759 6.353468e-01 7.496780e-01 5 148441238 148441502 265 + 0.438 0.547 0.535
ENSG00000145868 E049 105.4795363 0.0062482212 3.270427e-09 4.405693e-08 5 148441969 148442836 868 + 1.873 2.177 1.018