ENSG00000145819

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274498 ENSG00000145819 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP26 protein_coding protein_coding 2.2939 2.114212 2.536753 0.179304 0.2528306 0.2617313 0.26942880 0.05897334 0.41338505 0.007957954 0.15394909 2.6178595 0.11851667 0.02793333 0.160666667 0.13273333 4.289253e-02 2.262409e-08 FALSE TRUE
ENST00000421521 ENSG00000145819 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP26 protein_coding protein_coding 2.2939 2.114212 2.536753 0.179304 0.2528306 0.2617313 0.14054400 0.38390863 0.00000000 0.085770229 0.00000000 -5.2997891 0.06465833 0.17840000 0.000000000 -0.17840000 2.262409e-08 2.262409e-08 FALSE TRUE
ENST00000425417 ENSG00000145819 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP26 protein_coding protein_coding 2.2939 2.114212 2.536753 0.179304 0.2528306 0.2617313 0.15450111 0.05367913 0.34241564 0.053679126 0.06369799 2.4683855 0.06448333 0.02990000 0.132533333 0.10263333 1.584090e-01 2.262409e-08   FALSE
ENST00000443674 ENSG00000145819 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP26 protein_coding protein_coding 2.2939 2.114212 2.536753 0.179304 0.2528306 0.2617313 0.06269582 0.26360199 0.01074851 0.131940569 0.01074851 -3.7209992 0.02800417 0.11653333 0.004166667 -0.11236667 1.893309e-01 2.262409e-08 FALSE TRUE
ENST00000645722 ENSG00000145819 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP26 protein_coding protein_coding 2.2939 2.114212 2.536753 0.179304 0.2528306 0.2617313 1.25857936 1.02895998 1.28428546 0.065623787 0.19577888 0.3170158 0.54817917 0.48916667 0.524000000 0.03483333 9.396502e-01 2.262409e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145819 E001 10.2778570 0.0080071261 1.040986e-04 5.409430e-04 5 142770377 142770915 539 + 1.218 0.776 -1.641
ENSG00000145819 E002 0.0000000       5 142771119 142771375 257 +      
ENSG00000145819 E003 0.0000000       5 142772717 142772850 134 +      
ENSG00000145819 E004 7.7687552 0.0060196733 1.329680e-01 2.382441e-01 5 142873400 142873495 96 + 1.023 0.847 -0.663
ENSG00000145819 E005 0.0000000       5 142874893 142875109 217 +      
ENSG00000145819 E006 9.8764733 0.0023150283 2.742590e-01 4.133851e-01 5 142875110 142875171 62 + 1.091 0.978 -0.414
ENSG00000145819 E007 9.8292544 0.0019770989 9.740869e-01 9.878212e-01 5 142879374 142879445 72 + 1.035 1.039 0.012
ENSG00000145819 E008 10.6824724 0.0169437814 4.959214e-01 6.326612e-01 5 142885298 142885399 102 + 1.112 1.036 -0.273
ENSG00000145819 E009 13.3888875 0.0015144384 9.852622e-01 9.948087e-01 5 142894238 142894348 111 + 1.159 1.161 0.005
ENSG00000145819 E010 15.0244057 0.0012774618 9.197826e-01 9.533113e-01 5 142901935 142902039 105 + 1.210 1.201 -0.031
ENSG00000145819 E011 16.3546242 0.0012154307 6.052436e-02 1.275151e-01 5 142903540 142903643 104 + 1.316 1.161 -0.548
ENSG00000145819 E012 9.1531813 0.0139681107 1.913271e-01 3.153996e-01 5 142903644 142903669 26 + 1.081 0.926 -0.573
ENSG00000145819 E013 0.0000000       5 142907322 142907360 39 +      
ENSG00000145819 E014 0.0000000       5 142907361 142907508 148 +      
ENSG00000145819 E015 0.0000000       5 142907578 142907703 126 +      
ENSG00000145819 E016 15.7702086 0.0033698484 4.554860e-02 1.012003e-01 5 142907704 142907804 101 + 1.303 1.128 -0.622
ENSG00000145819 E017 0.0000000       5 142908722 142908882 161 +      
ENSG00000145819 E018 14.3860621 0.0012454122 1.429298e-02 3.889345e-02 5 142913199 142913293 95 + 1.283 1.066 -0.775
ENSG00000145819 E019 0.1482932 0.0418266446 4.153505e-01   5 142915542 142915684 143 + 0.000 0.132 11.291
ENSG00000145819 E020 0.6298062 0.0189494534 2.401806e-01 3.743419e-01 5 142919211 142919443 233 + 0.113 0.314 1.831
ENSG00000145819 E021 0.0000000       5 142921531 142922114 584 +      
ENSG00000145819 E022 17.2070178 0.0153867523 5.556901e-02 1.189535e-01 5 142932047 142932125 79 + 1.340 1.152 -0.663
ENSG00000145819 E023 0.0000000       5 142969331 142969408 78 +      
ENSG00000145819 E024 0.0000000       5 143010736 143010973 238 +      
ENSG00000145819 E025 14.0922890 0.0105569025 9.329683e-02 1.802724e-01 5 143014080 143014116 37 + 1.248 1.081 -0.597
ENSG00000145819 E026 0.1482932 0.0418266446 4.153505e-01   5 143014117 143014293 177 + 0.000 0.132 11.291
ENSG00000145819 E027 0.0000000       5 143014294 143014397 104 +      
ENSG00000145819 E028 13.5936468 0.0037066554 2.560068e-01 3.929712e-01 5 143037196 143037261 66 + 1.210 1.105 -0.377
ENSG00000145819 E029 0.2998086 0.0292308266 9.002135e-01   5 143041525 143041815 291 + 0.113 0.132 0.247
ENSG00000145819 E030 14.1393517 0.0013381201 6.262044e-01 7.421910e-01 5 143041816 143041890 75 + 1.194 1.150 -0.155
ENSG00000145819 E031 14.7115373 0.0012412532 2.427557e-01 3.774227e-01 5 143054439 143054526 88 + 1.241 1.139 -0.361
ENSG00000145819 E032 14.0671959 0.0017655324 8.754078e-01 9.239906e-01 5 143056028 143056082 55 + 1.185 1.171 -0.050
ENSG00000145819 E033 9.4484806 0.0020631931 8.989623e-01 9.395503e-01 5 143056083 143056086 4 + 1.023 1.010 -0.050
ENSG00000145819 E034 16.8335760 0.0013280827 6.241984e-01 7.406079e-01 5 143057642 143057747 106 + 1.270 1.230 -0.141
ENSG00000145819 E035 0.1817044 0.0395975610 4.143130e-01   5 143057858 143058159 302 + 0.000 0.132 11.303
ENSG00000145819 E036 14.9659798 0.0014611325 2.205721e-01 3.511017e-01 5 143120988 143121111 124 + 1.256 1.150 -0.374
ENSG00000145819 E037 5.6419912 0.0076015653 1.046440e-01 1.975811e-01 5 143121112 143121114 3 + 0.714 0.926 0.831
ENSG00000145819 E038 7.0416666 0.0023987430 1.059724e-01 1.995794e-01 5 143121115 143121147 33 + 0.804 0.994 0.723
ENSG00000145819 E039 5.0371877 0.0033227212 7.901364e-03 2.352971e-02 5 143133967 143133984 18 + 0.567 0.927 1.472
ENSG00000145819 E040 11.2416138 0.0015817061 6.386161e-01 7.522097e-01 5 143133985 143134105 121 + 1.059 1.104 0.165
ENSG00000145819 E041 15.5608730 0.0013358778 7.405831e-01 8.299621e-01 5 143147231 143147381 151 + 1.202 1.230 0.098
ENSG00000145819 E042 0.1451727 0.0437812278 5.711612e-01   5 143147382 143147516 135 + 0.113 0.000 -12.006
ENSG00000145819 E043 0.0000000       5 143164913 143165444 532 +      
ENSG00000145819 E044 0.1817044 0.0395975610 4.143130e-01   5 143166027 143166097 71 + 0.000 0.132 11.303
ENSG00000145819 E045 0.0000000       5 143168555 143168970 416 +      
ENSG00000145819 E046 0.0000000       5 143169474 143170663 1190 +      
ENSG00000145819 E047 0.1515154 0.0423181325 5.717167e-01   5 143172959 143173032 74 + 0.113 0.000 -12.014
ENSG00000145819 E048 0.1515154 0.0423181325 5.717167e-01   5 143173033 143173155 123 + 0.113 0.000 -12.014
ENSG00000145819 E049 0.2214452 0.0394721851 4.132300e-01   5 143202231 143203737 1507 + 0.000 0.132 11.306
ENSG00000145819 E050 7.6509385 0.0022876789 8.768175e-01 9.249323e-01 5 143207198 143207199 2 + 0.927 0.945 0.065
ENSG00000145819 E051 16.4678773 0.0108977634 6.124302e-01 7.313639e-01 5 143207200 143207308 109 + 1.263 1.212 -0.180
ENSG00000145819 E052 2.5433380 0.0058197529 2.452066e-01 3.802783e-01 5 143207309 143207382 74 + 0.632 0.443 -0.888
ENSG00000145819 E053 3.0465071 0.0085988663 7.585766e-01 8.431394e-01 5 143207383 143207443 61 + 0.632 0.584 -0.209
ENSG00000145819 E054 2.9808292 0.0053995755 9.188868e-01 9.527633e-01 5 143207444 143207473 30 + 0.600 0.584 -0.071
ENSG00000145819 E055 20.8795408 0.0015268228 9.388389e-01 9.656001e-01 5 143213997 143214085 89 + 1.340 1.334 -0.022
ENSG00000145819 E056 11.9127000 0.0088675314 8.750305e-01 9.237056e-01 5 143214086 143214088 3 + 1.102 1.116 0.051
ENSG00000145819 E057 7.7267556 0.0030096293 1.126992e-01 2.094832e-01 5 143216187 143216770 584 + 0.843 1.024 0.682
ENSG00000145819 E058 271.3098883 0.0003280565 1.460330e-07 1.436946e-06 5 143222358 143229011 6654 + 2.384 2.474 0.302