ENSG00000145817

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274496 ENSG00000145817 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF5 protein_coding protein_coding 27.87229 8.099672 45.31415 1.339905 0.1106675 2.482565 6.727565 4.1223667 11.035436 1.0280256 0.5548106 1.418410 0.29797083 0.4991000 0.2435333 -0.25556667 0.0006472839 0.0006472839 FALSE TRUE
ENST00000448443 ENSG00000145817 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF5 protein_coding protein_coding 27.87229 8.099672 45.31415 1.339905 0.1106675 2.482565 3.204208 0.5265240 4.160798 0.2856369 0.2857814 2.958609 0.12143750 0.0587000 0.0918000 0.03310000 0.6873151986 0.0006472839 FALSE TRUE
ENST00000508754 ENSG00000145817 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF5 protein_coding retained_intron 27.87229 8.099672 45.31415 1.339905 0.1106675 2.482565 2.273833 0.1779841 3.573778 0.0723692 0.5261232 4.252799 0.07213333 0.0247000 0.0789000 0.05420000 0.0636514638 0.0006472839 FALSE TRUE
ENST00000522203 ENSG00000145817 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF5 protein_coding protein_coding 27.87229 8.099672 45.31415 1.339905 0.1106675 2.482565 1.067549 0.0000000 2.507636 0.0000000 1.3490731 7.975926 0.02191667 0.0000000 0.0552000 0.05520000 0.3854846457 0.0006472839 FALSE FALSE
MSTRG.27098.4 ENSG00000145817 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF5 protein_coding   27.87229 8.099672 45.31415 1.339905 0.1106675 2.482565 12.763912 3.0742074 20.762878 0.4163841 0.8894966 2.751729 0.43650833 0.3869667 0.4582333 0.07126667 0.5308857761 0.0006472839 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145817 E001 130.457744 0.0100724606 2.577471e-04 0.0012075133 5 144158162 144159272 1111 - 1.985 2.226 0.807
ENSG00000145817 E002 120.122534 0.0043404583 3.474409e-05 0.0002032974 5 144159273 144159478 206 - 1.960 2.166 0.690
ENSG00000145817 E003 655.594269 0.0008281703 8.364370e-03 0.0246992457 5 144159479 144160477 999 - 2.738 2.797 0.199
ENSG00000145817 E004 152.669292 0.0002123209 5.413483e-01 0.6723489779 5 144160478 144160559 82 - 2.123 2.120 -0.011
ENSG00000145817 E005 204.331024 0.0001998221 8.032464e-01 0.8747564248 5 144162218 144162361 144 - 2.245 2.254 0.032
ENSG00000145817 E006 129.254183 0.0002340741 8.840684e-01 0.9298834811 5 144162362 144162399 38 - 2.045 2.066 0.073
ENSG00000145817 E007 5.220792 0.0031777574 1.530218e-01 0.2657809621 5 144163863 144164110 248 - 0.776 0.551 -0.962
ENSG00000145817 E008 194.453259 0.0002717193 8.595038e-02 0.1689077127 5 144164111 144164254 144 - 2.234 2.199 -0.118
ENSG00000145817 E009 80.759636 0.0003332340 2.493415e-02 0.0617372104 5 144164255 144164256 2 - 1.867 1.776 -0.307
ENSG00000145817 E010 233.874956 0.0002429342 1.335902e-04 0.0006748818 5 144165432 144165600 169 - 2.325 2.234 -0.304
ENSG00000145817 E011 90.808419 0.0074849289 1.264923e-01 0.2292704833 5 144165601 144165604 4 - 1.917 1.826 -0.304
ENSG00000145817 E012 207.208965 0.0022425517 7.106786e-04 0.0029370198 5 144169846 144169965 120 - 2.277 2.161 -0.388
ENSG00000145817 E013 3.138578 0.0197111991 7.994556e-01 0.8720756737 5 144170284 144170534 251 - 0.582 0.550 -0.147
ENSG00000145817 E014 133.524516 0.0004231720 6.588777e-03 0.0201573558 5 144170535 144170714 180 - 2.081 1.994 -0.292