ENSG00000145782

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000500945 ENSG00000145782 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG12 protein_coding protein_coding 19.64244 10.84309 27.89937 1.617582 0.2488245 1.362643 1.596377 0.4449615 2.395590 0.22309039 0.8802559 2.4025743 0.06836667 0.04193333 0.08643333 0.04450000 6.374147e-01 4.509231e-07 FALSE FALSE
ENST00000505252 ENSG00000145782 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG12 protein_coding retained_intron 19.64244 10.84309 27.89937 1.617582 0.2488245 1.362643 1.116317 0.1929325 1.399322 0.07073817 0.1230635 2.7959297 0.05283333 0.01963333 0.05010000 0.03046667 3.181349e-02 4.509231e-07   FALSE
ENST00000509910 ENSG00000145782 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG12 protein_coding protein_coding 19.64244 10.84309 27.89937 1.617582 0.2488245 1.362643 5.379483 2.3514854 8.375010 0.40613446 0.5623156 1.8281178 0.25750417 0.21663333 0.30023333 0.08360000 1.053195e-01 4.509231e-07 FALSE TRUE
ENST00000511984 ENSG00000145782 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG12 protein_coding retained_intron 19.64244 10.84309 27.89937 1.617582 0.2488245 1.362643 7.415355 6.9314139 8.662181 1.27557715 0.6562209 0.3211653 0.43460833 0.63263333 0.31030000 -0.32233333 4.509231e-07 4.509231e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145782 E001 202.358157 0.0070416475 1.339060e-02 3.682299e-02 5 115828200 115830340 2141 - 2.310 2.184 -0.421
ENSG00000145782 E002 60.947499 0.0003871578 1.574370e-01 2.717010e-01 5 115830341 115830672 332 - 1.784 1.703 -0.272
ENSG00000145782 E003 146.850789 0.0002670459 3.083411e-02 7.359375e-02 5 115830673 115831274 602 - 2.160 2.081 -0.265
ENSG00000145782 E004 94.013085 0.0008412396 1.105604e-07 1.114351e-06 5 115831275 115831478 204 - 2.007 1.760 -0.834
ENSG00000145782 E005 29.951680 0.0117415413 2.523847e-02 6.236438e-02 5 115831479 115831487 9 - 1.516 1.296 -0.761
ENSG00000145782 E006 34.009972 0.0025518550 7.446950e-03 2.237841e-02 5 115831488 115831511 24 - 1.568 1.362 -0.707
ENSG00000145782 E007 29.936555 0.0007120096 2.150864e-02 5.466085e-02 5 115831512 115831513 2 - 1.509 1.331 -0.613
ENSG00000145782 E008 42.801935 0.0004878067 2.959742e-02 7.116565e-02 5 115831514 115831545 32 - 1.650 1.508 -0.484
ENSG00000145782 E009 59.392964 0.0003875703 5.850834e-02 1.240791e-01 5 115831546 115831581 36 - 1.781 1.675 -0.360
ENSG00000145782 E010 51.689550 0.0004497940 1.802881e-01 3.015364e-01 5 115831582 115831583 2 - 1.716 1.633 -0.279
ENSG00000145782 E011 114.743093 0.0004305584 3.840354e-02 8.810807e-02 5 115831584 115831719 136 - 2.016 2.078 0.211
ENSG00000145782 E012 162.113891 0.0002634218 4.149565e-14 1.245244e-12 5 115831720 115831863 144 - 2.113 2.314 0.671
ENSG00000145782 E013 133.688078 0.0002325639 3.353930e-10 5.410354e-09 5 115832602 115832664 63 - 2.035 2.219 0.616
ENSG00000145782 E014 15.548092 0.0087666542 1.259993e-01 2.285716e-01 5 115832665 115833511 847 - 1.229 1.051 -0.637
ENSG00000145782 E015 5.175515 0.0171827039 2.415526e-03 8.508212e-03 5 115833512 115833598 87 - 0.874 0.317 -2.594
ENSG00000145782 E016 20.577748 0.0022749393 2.282508e-05 1.396125e-04 5 115833599 115834352 754 - 1.391 0.958 -1.547
ENSG00000145782 E017 7.819593 0.0044115878 1.015925e-02 2.915679e-02 5 115834918 115835161 244 - 1.002 0.626 -1.487
ENSG00000145782 E018 177.004654 0.0003010272 8.104631e-10 1.222353e-08 5 115837628 115837764 137 - 2.165 2.322 0.522
ENSG00000145782 E019 2.013000 0.0600766615 3.952181e-01 5.390416e-01 5 115837765 115837870 106 - 0.501 0.318 -1.007
ENSG00000145782 E020 17.819952 0.0009832523 1.307727e-11 2.672545e-10 5 115837871 115839494 1624 - 1.377 0.499 -3.405
ENSG00000145782 E021 5.212989 0.0390297932 2.348565e-01 3.681805e-01 5 115840497 115840551 55 - 0.826 0.623 -0.835
ENSG00000145782 E022 5.274386 0.0816808871 5.012639e-01 6.374122e-01 5 115840552 115840612 61 - 0.813 0.673 -0.566
ENSG00000145782 E023 9.216941 0.0069939043 6.030315e-03 1.869120e-02 5 115840613 115840817 205 - 1.065 0.678 -1.496
ENSG00000145782 E024 13.363899 0.0038818463 1.411977e-02 3.849899e-02 5 115840818 115840934 117 - 1.192 0.903 -1.056
ENSG00000145782 E025 13.940543 0.0012075839 4.165686e-06 3.016269e-05 5 115840935 115841389 455 - 1.253 0.678 -2.166
ENSG00000145782 E026 141.376739 0.0002421784 2.067332e-05 1.278105e-04 5 115841390 115841837 448 - 2.083 2.203 0.401