ENSG00000145740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380860 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding protein_coding 31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 6.5833990 9.0419916 8.296541 0.74003360 0.9016159 -0.1239875 0.27180833 0.4346333 0.19106667 -0.24356667 0.0001103390 0.000110339 FALSE FALSE
ENST00000396591 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding protein_coding 31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 16.8098834 5.8376356 25.170899 1.02685605 0.7937484 2.1064045 0.48708333 0.2838333 0.57906667 0.29523333 0.0032178656 0.000110339 FALSE TRUE
ENST00000502979 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding protein_coding 31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 1.5028162 2.2324567 1.254038 1.29672598 0.7443860 -0.8270404 0.05290833 0.1060667 0.02973333 -0.07633333 0.8268967856 0.000110339   FALSE
ENST00000512367 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding retained_intron 31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 2.1989587 0.3830783 2.589763 0.38307826 1.0164751 2.7254916 0.05189167 0.0179000 0.05833333 0.04043333 0.2051757344 0.000110339 FALSE FALSE
MSTRG.26298.3 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding   31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 2.2660174 0.9176950 3.989377 0.07143715 0.2985770 2.1080527 0.06397917 0.0439000 0.09166667 0.04776667 0.0002181396 0.000110339 FALSE TRUE
MSTRG.26298.4 ENSG00000145740 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A5 protein_coding   31.55677 20.89308 43.47417 0.9001625 1.33454 1.056774 0.6583481 1.6085785 0.000000 1.60857851 0.0000000 -7.3385835 0.02642500 0.0727000 0.00000000 -0.07270000 0.7081717591 0.000110339 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145740 E001 0.0000000       5 69093732 69093857 126 +      
ENSG00000145740 E002 0.0000000       5 69093858 69093920 63 +      
ENSG00000145740 E003 13.0372745 0.0019076453 1.650001e-02 4.384365e-02 5 69093921 69093990 70 + 1.171 0.935 -0.861
ENSG00000145740 E004 19.3331837 0.0009654571 6.761238e-01 7.811820e-01 5 69093991 69094013 23 + 1.272 1.265 -0.026
ENSG00000145740 E005 92.7180595 0.0057132468 2.541493e-01 3.907912e-01 5 69094014 69094088 75 + 1.946 1.909 -0.124
ENSG00000145740 E006 149.6418378 0.0116398233 4.768384e-01 6.154574e-01 5 69094089 69094197 109 + 2.147 2.127 -0.065
ENSG00000145740 E007 178.3423410 0.0161443930 8.240321e-01 8.891279e-01 5 69094198 69094338 141 + 2.214 2.223 0.030
ENSG00000145740 E008 156.7998329 0.0017941098 1.144528e-03 4.452583e-03 5 69100807 69100929 123 + 2.112 2.254 0.476
ENSG00000145740 E009 0.6600838 0.0516962463 3.595505e-01 5.038820e-01 5 69102572 69103061 490 + 0.143 0.320 1.484
ENSG00000145740 E010 170.0970639 0.0002083025 9.919100e-06 6.599044e-05 5 69103062 69103128 67 + 2.144 2.300 0.522
ENSG00000145740 E011 262.8857668 0.0103719341 2.590222e-33 5.601711e-31 5 69103962 69104630 669 + 2.060 2.733 2.248
ENSG00000145740 E012 150.2461615 0.0002963178 2.992471e-02 7.181499e-02 5 69104631 69104716 86 + 2.111 2.208 0.324
ENSG00000145740 E013 6.6040551 0.0025382107 8.831736e-10 1.322750e-08 5 69104717 69104740 24 + 0.440 1.225 3.170
ENSG00000145740 E014 141.7777425 0.0023312873 1.885461e-06 1.475280e-05 5 69108349 69108436 88 + 2.164 1.992 -0.573
ENSG00000145740 E015 170.5206959 0.0019241930 1.283098e-08 1.550546e-07 5 69113140 69113227 88 + 2.247 2.059 -0.631
ENSG00000145740 E016 174.7033096 0.0019335089 7.761449e-10 1.175178e-08 5 69114420 69114496 77 + 2.261 2.057 -0.685
ENSG00000145740 E017 261.4932798 0.0008721641 5.208403e-15 1.786882e-13 5 69115237 69115407 171 + 2.434 2.236 -0.659
ENSG00000145740 E018 321.0374172 0.0002068789 3.068764e-15 1.089929e-13 5 69115926 69116189 264 + 2.514 2.362 -0.505
ENSG00000145740 E019 82.4856174 0.0003032824 4.287554e-02 9.631517e-02 5 69116190 69116214 25 + 1.903 1.845 -0.195
ENSG00000145740 E020 105.1793806 0.0003128162 2.570458e-02 6.332781e-02 5 69116394 69116435 42 + 2.006 1.950 -0.190
ENSG00000145740 E021 189.2554476 0.0003269343 7.610089e-04 3.118894e-03 5 69116436 69116602 167 + 2.264 2.194 -0.231
ENSG00000145740 E022 155.5742304 0.0019176477 1.126910e-02 3.180574e-02 5 69117239 69117342 104 + 2.178 2.111 -0.221
ENSG00000145740 E023 121.0227439 0.0018909878 1.873719e-01 3.104327e-01 5 69117343 69117396 54 + 2.057 2.032 -0.085
ENSG00000145740 E024 1.0436561 0.0145540470 6.788187e-02 1.398542e-01 5 69118372 69118498 127 + 0.374 0.001 -9.828
ENSG00000145740 E025 215.2871102 0.0029294793 1.049209e-01 1.979756e-01 5 69118499 69118628 130 + 2.307 2.275 -0.106
ENSG00000145740 E026 157.2329801 0.0002078081 4.184178e-02 9.443524e-02 5 69121694 69121746 53 + 2.174 2.140 -0.113
ENSG00000145740 E027 244.7053550 0.0008918249 5.539304e-02 1.186626e-01 5 69121747 69121895 149 + 2.360 2.335 -0.084
ENSG00000145740 E028 182.2603791 0.0002619070 3.799718e-01 5.242377e-01 5 69123199 69123342 144 + 2.209 2.264 0.184
ENSG00000145740 E029 162.9425405 0.0002349541 3.239353e-01 4.672769e-01 5 69123343 69123425 83 + 2.160 2.219 0.199
ENSG00000145740 E030 2.1014797 0.0065659336 2.343766e-01 3.676176e-01 5 69123426 69123539 114 + 0.523 0.320 -1.103
ENSG00000145740 E031 207.4484369 0.0002236708 3.907684e-01 5.347165e-01 5 69128004 69128132 129 + 2.268 2.321 0.176
ENSG00000145740 E032 538.9780176 0.0004584892 1.130081e-06 9.278024e-06 5 69129447 69131069 1623 + 2.660 2.777 0.389