ENSG00000145736

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274400 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding protein_coding 43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 4.294067 2.0969888 7.228943 0.3608421 0.3888178 1.780596 0.12331667 0.15626667 0.09846667 -0.0578000000 4.986693e-02 7.785789e-13 FALSE TRUE
ENST00000520085 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding processed_transcript 43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 5.001428 0.3356833 10.150202 0.3356833 0.5956612 4.877334 0.09243750 0.02683333 0.13750000 0.1106666667 9.936788e-02 7.785789e-13 TRUE FALSE
ENST00000523003 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding retained_intron 43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 2.931622 1.9191753 3.724050 0.1331290 0.2835403 0.952757 0.08960417 0.14543333 0.05033333 -0.0951000000 7.785789e-13 7.785789e-13 FALSE TRUE
MSTRG.26350.11 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding   43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 4.511597 1.3951869 7.274895 0.8486492 0.8490602 2.374146 0.09844167 0.09793333 0.09816667 0.0002333333 8.650030e-01 7.785789e-13 FALSE TRUE
MSTRG.26350.8 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding   43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 15.870801 3.9134112 28.188369 0.2027162 0.9349772 2.845431 0.32081250 0.30060000 0.38226667 0.0816666667 2.470675e-01 7.785789e-13 FALSE TRUE
MSTRG.26350.9 ENSG00000145736 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2 protein_coding   43.73439 13.23695 73.79243 0.9654057 3.018297 2.478008 6.026836 2.4371762 9.235993 0.1811923 0.8047111 1.917710 0.15798333 0.18540000 0.12503333 -0.0603666667 8.088053e-02 7.785789e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145736 E001 46.5834738 0.0005845969 1.396612e-01 2.475548e-01 5 71032670 71033167 498 - 1.599 1.682 0.281
ENSG00000145736 E002 67.8028879 0.0004196127 4.381827e-01 5.800723e-01 5 71033168 71033643 476 - 1.774 1.810 0.121
ENSG00000145736 E003 20.2793437 0.0008823042 1.178131e-01 2.168063e-01 5 71033644 71034169 526 - 1.306 1.160 -0.513
ENSG00000145736 E004 78.3718667 0.0009836814 3.049621e-04 1.399703e-03 5 71034170 71035015 846 - 1.880 1.699 -0.614
ENSG00000145736 E005 11.8168728 0.0090011342 9.209254e-02 1.783820e-01 5 71035016 71035075 60 - 1.100 0.888 -0.787
ENSG00000145736 E006 14.8336610 0.0485861548 9.063782e-02 1.761333e-01 5 71035076 71035328 253 - 1.197 0.948 -0.903
ENSG00000145736 E007 3.3904142 0.0047260136 6.631562e-01 7.713033e-01 5 71035329 71035581 253 - 0.614 0.538 -0.347
ENSG00000145736 E008 8.3631306 0.0036991435 1.703595e-01 2.886357e-01 5 71035582 71035684 103 - 0.961 0.771 -0.732
ENSG00000145736 E009 23.2928883 0.0019791337 7.648735e-01 8.478223e-01 5 71035685 71035796 112 - 1.327 1.350 0.080
ENSG00000145736 E010 25.6551684 0.0153385112 6.456425e-01 7.577111e-01 5 71037507 71037546 40 - 1.383 1.326 -0.199
ENSG00000145736 E011 25.8775466 0.0084078815 4.212294e-01 5.643650e-01 5 71038429 71038481 53 - 1.392 1.313 -0.276
ENSG00000145736 E012 85.3680309 0.0003288544 7.779648e-01 8.571575e-01 5 71041522 71041624 103 - 1.878 1.889 0.036
ENSG00000145736 E013 86.4756514 0.0003764466 7.248735e-01 8.182735e-01 5 71042181 71042284 104 - 1.882 1.896 0.045
ENSG00000145736 E014 40.3713323 0.0013419631 4.436387e-01 5.852257e-01 5 71045444 71045507 64 - 1.549 1.597 0.161
ENSG00000145736 E015 2.2466524 0.0066001222 3.958463e-01 5.396323e-01 5 71047456 71048005 550 - 0.512 0.347 -0.878
ENSG00000145736 E016 39.1774268 0.0005892558 2.554091e-02 6.299832e-02 5 71048006 71048088 83 - 1.514 1.648 0.456
ENSG00000145736 E017 20.9331312 0.0090305079 9.325044e-01 9.614734e-01 5 71048089 71048113 25 - 1.294 1.285 -0.033
ENSG00000145736 E018 2.2477983 0.0065693702 1.092105e-01 2.043801e-01 5 71048114 71048761 648 - 0.534 0.207 -1.985
ENSG00000145736 E019 33.2167647 0.0007072713 9.994414e-01 1.000000e+00 5 71048762 71048849 88 - 1.483 1.482 -0.003
ENSG00000145736 E020 1.7788691 0.0078945415 2.099024e-01 3.384229e-01 5 71048850 71049067 218 - 0.463 0.207 -1.638
ENSG00000145736 E021 65.3914579 0.0004582195 1.888581e-01 3.123247e-01 5 71049068 71049158 91 - 1.782 1.714 -0.229
ENSG00000145736 E022 0.1451727 0.0433665843 1.000000e+00   5 71050217 71050305 89 - 0.069 0.000 -11.822
ENSG00000145736 E023 24.5833649 0.0008501647 3.025263e-09 4.100795e-08 5 71055030 71055351 322 - 1.206 1.623 1.445
ENSG00000145736 E024 97.7149776 0.0020637862 7.375655e-01 8.276985e-01 5 71055352 71055457 106 - 1.933 1.944 0.034
ENSG00000145736 E025 0.3634088 0.5662398304 7.651557e-02   5 71057875 71059385 1511 - 0.000 0.349 12.953
ENSG00000145736 E026 44.3098110 0.0006623430 8.788393e-01 9.261642e-01 5 71059690 71059744 55 - 1.601 1.590 -0.038
ENSG00000145736 E027 18.7150068 0.0039278204 7.978147e-01 8.709925e-01 5 71060120 71060170 51 - 1.237 1.258 0.074
ENSG00000145736 E028 0.0000000       5 71060507 71060843 337 -      
ENSG00000145736 E029 11.4557834 0.0023695641 1.263061e-01 2.290076e-01 5 71060844 71060930 87 - 1.000 1.160 0.581
ENSG00000145736 E030 3.9900550 0.0045423666 1.143581e-01 2.119035e-01 5 71061272 71061308 37 - 0.576 0.813 0.992
ENSG00000145736 E031 0.0000000       5 71061410 71061687 278 -      
ENSG00000145736 E032 3.3203957 0.0047069086 9.367755e-01 9.642470e-01 5 71061688 71061750 63 - 0.596 0.608 0.056
ENSG00000145736 E033 1.8165466 0.0079176348 2.116153e-01 3.403968e-01 5 71061751 71061765 15 - 0.463 0.207 -1.637
ENSG00000145736 E034 2.6917355 0.0055977594 5.564807e-02 1.190931e-01 5 71062708 71062751 44 - 0.596 0.207 -2.265
ENSG00000145736 E035 2.6885132 0.0057140598 2.335368e-01 3.666023e-01 5 71062752 71062796 45 - 0.576 0.347 -1.178
ENSG00000145736 E036 0.0000000       5 71062797 71062799 3 -      
ENSG00000145736 E037 0.1482932 0.0411597534 1.233989e-01   5 71065125 71065222 98 - 0.000 0.207 13.607
ENSG00000145736 E038 1.4694955 0.0106276865 3.263531e-01 4.697929e-01 5 71067296 71067493 198 - 0.408 0.207 -1.348
ENSG00000145736 E039 0.2903454 0.2851888528 1.000000e+00   5 71067494 71067654 161 - 0.129 0.000 -12.009
ENSG00000145736 E040 0.5901540 0.0193825533 9.025042e-01 9.418959e-01 5 71067655 71067753 99 - 0.182 0.207 0.236
ENSG00000145736 E041 0.1472490 0.0435156766 1.000000e+00   5 71289595 71289755 161 - 0.069 0.000 -11.822