ENSG00000145734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358731 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding protein_coding 6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 3.6604013 0.1864690 7.1994441 0.14554654 0.8062639 5.197514 0.38012083 0.10333333 0.62740000 0.52406667 0.010680331 0.002875305 FALSE TRUE
ENST00000514903 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding nonsense_mediated_decay 6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 0.5790617 0.1842946 0.7646360 0.13530862 0.2815166 1.995273 0.11617500 0.10300000 0.06590000 -0.03710000 0.977739273 0.002875305 TRUE TRUE
ENST00000525844 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding nonsense_mediated_decay 6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 0.7812040 1.0848676 0.4354069 0.06466647 0.2290796 -1.297561 0.28893750 0.64733333 0.03856667 -0.60876667 0.002875305 0.002875305 TRUE TRUE
MSTRG.26356.12 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding   6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 0.2428957 0.0000000 0.8381369 0.00000000 0.6181210 6.406225 0.02515833 0.00000000 0.07103333 0.07103333 0.557420932 0.002875305 FALSE TRUE
MSTRG.26356.13 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding   6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 0.2217302 0.1150761 0.0000000 0.11507607 0.0000000 -3.644734 0.03267083 0.06623333 0.00000000 -0.06623333 0.426672889 0.002875305 FALSE TRUE
MSTRG.26356.14 ENSG00000145734 HEK293_OSMI2_2hA HEK293_TMG_2hB BDP1 protein_coding   6.599871 1.70177 11.50222 0.112938 0.204945 2.749605 0.4132307 0.1038414 0.6617702 0.05891710 0.4290357 2.560942 0.07315417 0.06316667 0.05766667 -0.00550000 0.925826965 0.002875305 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145734 E001 0.0000000       5 71455603 71455650 48 +      
ENSG00000145734 E002 0.9641468 0.0121624489 4.446441e-01 5.862009e-01 5 71455651 71455666 16 + 0.146 0.367 1.731
ENSG00000145734 E003 1.6983156 0.0542606383 8.601084e-01 9.137629e-01 5 71455667 71455677 11 + 0.255 0.367 0.736
ENSG00000145734 E004 3.1762301 0.0672542060 7.460903e-01 8.339405e-01 5 71455678 71455685 8 + 0.401 0.563 0.806
ENSG00000145734 E005 3.6138245 0.0537584987 8.869171e-01 9.316901e-01 5 71455686 71455693 8 + 0.440 0.563 0.595
ENSG00000145734 E006 4.8003495 0.1010182769 8.542533e-01 9.098368e-01 5 71455694 71455735 42 + 0.531 0.563 0.148
ENSG00000145734 E007 5.5493938 0.0907821323 6.900688e-01 7.918617e-01 5 71455736 71455751 16 + 0.579 0.563 -0.076
ENSG00000145734 E008 14.5063863 0.0267793392 2.422274e-02 6.027040e-02 5 71455752 71455894 143 + 0.938 0.561 -1.538
ENSG00000145734 E009 27.8524968 0.0084590398 1.502364e-02 4.054103e-02 5 71455895 71456089 195 + 1.189 0.952 -0.863
ENSG00000145734 E010 20.9901915 0.0094965612 5.481893e-02 1.176869e-01 5 71458579 71458664 86 + 1.072 0.883 -0.701
ENSG00000145734 E011 38.2291093 0.0091818633 1.623276e-03 6.036053e-03 5 71458665 71458855 191 + 1.321 1.012 -1.103
ENSG00000145734 E012 27.6887083 0.0098356679 1.536028e-01 2.665652e-01 5 71461817 71461926 110 + 1.180 1.111 -0.245
ENSG00000145734 E013 18.7376206 0.0031414876 5.971774e-01 7.189837e-01 5 71464058 71464117 60 + 1.015 1.065 0.182
ENSG00000145734 E014 25.8477717 0.0008240152 7.380162e-01 8.280179e-01 5 71466096 71466221 126 + 1.139 1.228 0.315
ENSG00000145734 E015 21.8173185 0.0009177602 3.124133e-01 4.549536e-01 5 71467354 71467487 134 + 1.077 1.065 -0.046
ENSG00000145734 E016 16.7869790 0.0010506939 2.376227e-02 5.932644e-02 5 71470395 71470489 95 + 0.987 0.697 -1.131
ENSG00000145734 E017 15.9776981 0.0011469552 6.235743e-05 3.430546e-04 5 71483842 71483896 55 + 0.984 0.000 -20.235
ENSG00000145734 E018 13.2537079 0.0016501033 4.370438e-03 1.417799e-02 5 71486484 71486530 47 + 0.905 0.367 -2.407
ENSG00000145734 E019 7.9221958 0.0039204314 6.348489e-02 1.325043e-01 5 71486531 71486534 4 + 0.712 0.367 -1.648
ENSG00000145734 E020 22.4605994 0.0088965488 3.122718e-03 1.062634e-02 5 71486535 71486627 93 + 1.108 0.697 -1.572
ENSG00000145734 E021 53.3793126 0.0004123512 7.262590e-03 2.190815e-02 5 71489404 71489682 279 + 1.453 1.320 -0.463
ENSG00000145734 E022 33.2551348 0.0008043981 5.570177e-02 1.191838e-01 5 71490984 71491131 148 + 1.256 1.154 -0.361
ENSG00000145734 E023 0.3332198 0.0295845196 7.607045e-02   5 71494465 71495249 785 + 0.033 0.367 4.052
ENSG00000145734 E024 38.1840409 0.0005551083 1.974782e-04 9.530419e-04 5 71495250 71495408 159 + 1.323 0.952 -1.335
ENSG00000145734 E025 42.3016379 0.0005527231 3.905179e-02 8.929146e-02 5 71497270 71497426 157 + 1.352 1.261 -0.319
ENSG00000145734 E026 35.4051673 0.0123870897 2.529323e-01 3.893781e-01 5 71501562 71501653 92 + 1.273 1.262 -0.040
ENSG00000145734 E027 44.4882897 0.0050921387 5.440808e-02 1.169706e-01 5 71502599 71502791 193 + 1.372 1.292 -0.279
ENSG00000145734 E028 33.8996667 0.0057490948 6.171839e-02 1.295218e-01 5 71504621 71504751 131 + 1.260 1.155 -0.372
ENSG00000145734 E029 109.0924343 0.0023759362 7.943091e-07 6.741308e-06 5 71509465 71510095 631 + 1.760 1.498 -0.891
ENSG00000145734 E030 45.5421796 0.0027007570 5.640170e-05 3.136229e-04 5 71510096 71510251 156 + 1.397 1.012 -1.369
ENSG00000145734 E031 43.9997706 0.0004680004 3.829914e-06 2.798387e-05 5 71510252 71510413 162 + 1.385 0.882 -1.811
ENSG00000145734 E032 41.3455458 0.0020147718 2.900979e-06 2.177941e-05 5 71510414 71510578 165 + 1.361 0.799 -2.051
ENSG00000145734 E033 94.1770523 0.0003167105 2.491698e-05 1.511559e-04 5 71510579 71511151 573 + 1.695 1.498 -0.672
ENSG00000145734 E034 0.1472490 0.0434298125 4.969766e-01   5 71511152 71511350 199 + 0.033 0.000 -13.480
ENSG00000145734 E035 36.6660147 0.0010853565 4.611346e-02 1.022455e-01 5 71512241 71512428 188 + 1.294 1.193 -0.359
ENSG00000145734 E036 44.2866723 0.0027228091 2.173176e-01 3.471580e-01 5 71513185 71513407 223 + 1.366 1.372 0.022
ENSG00000145734 E037 46.9335577 0.0072442077 1.576822e-01 2.720383e-01 5 71514944 71515122 179 + 1.392 1.373 -0.066
ENSG00000145734 E038 61.2372328 0.0006149151 2.620712e-02 6.436920e-02 5 71516061 71516271 211 + 1.505 1.440 -0.225
ENSG00000145734 E039 47.7834157 0.0010830759 1.794796e-02 4.702236e-02 5 71517322 71517452 131 + 1.406 1.291 -0.398
ENSG00000145734 E040 29.1481028 0.0017537987 1.655033e-01 2.823549e-01 5 71522289 71522315 27 + 1.198 1.154 -0.157
ENSG00000145734 E041 54.8460091 0.0004231060 2.264503e-01 3.581640e-01 5 71522316 71522490 175 + 1.453 1.479 0.090
ENSG00000145734 E042 20.0927398 0.0009168395 4.496241e-01 5.908181e-01 5 71522756 71522792 37 + 1.044 1.065 0.075
ENSG00000145734 E043 45.7319683 0.0004883411 5.568860e-02 1.191650e-01 5 71522793 71522949 157 + 1.383 1.320 -0.221
ENSG00000145734 E044 88.0687212 0.0003243553 7.959142e-02 1.588985e-01 5 71523939 71524323 385 + 1.653 1.663 0.034
ENSG00000145734 E045 39.2721159 0.0023102948 6.617283e-01 7.701578e-01 5 71532308 71532373 66 + 1.308 1.396 0.305
ENSG00000145734 E046 39.8227315 0.0006304084 4.487367e-01 5.899982e-01 5 71532374 71532427 54 + 1.317 1.372 0.192
ENSG00000145734 E047 36.9043922 0.0005692347 5.003866e-01 6.366465e-01 5 71539042 71539078 37 + 1.285 1.347 0.213
ENSG00000145734 E048 44.0286047 0.0004717810 1.383659e-01 2.458245e-01 5 71539557 71539649 93 + 1.364 1.347 -0.061
ENSG00000145734 E049 13.4202195 0.0012798719 7.217786e-01 8.160246e-01 5 71541454 71541456 3 + 0.887 0.952 0.244
ENSG00000145734 E050 24.4182842 0.0018400611 8.933416e-01 9.358349e-01 5 71541457 71541511 55 + 1.116 1.228 0.398
ENSG00000145734 E051 51.8726520 0.0004560411 3.526066e-01 4.968594e-01 5 71541512 71541682 171 + 1.430 1.479 0.172
ENSG00000145734 E052 62.1406670 0.0061086550 2.466647e-01 3.820391e-01 5 71542105 71542265 161 + 1.507 1.533 0.090
ENSG00000145734 E053 51.9393786 0.0039104659 8.182889e-02 1.624297e-01 5 71544357 71544507 151 + 1.436 1.395 -0.142
ENSG00000145734 E054 48.9277783 0.0005511962 1.295019e-01 2.334612e-01 5 71545039 71545219 181 + 1.408 1.396 -0.044
ENSG00000145734 E055 1.6285115 0.3423625681 3.566202e-01 5.010057e-01 5 71545220 71545477 258 + 0.235 0.552 1.835
ENSG00000145734 E056 38.6844162 0.0006167795 9.071614e-01 9.450436e-01 5 71548682 71548745 64 + 1.296 1.440 0.498
ENSG00000145734 E057 55.5610661 0.0004428756 4.383177e-01 5.802064e-01 5 71549420 71549606 187 + 1.442 1.638 0.669
ENSG00000145734 E058 57.5894719 0.0004143737 9.790330e-01 9.909328e-01 5 71553116 71553320 205 + 1.464 1.596 0.451
ENSG00000145734 E059 31.4896756 0.0016933490 6.033650e-01 7.241727e-01 5 71556886 71556925 40 + 1.220 1.292 0.253
ENSG00000145734 E060 65.2417298 0.0003741080 5.940362e-01 7.163304e-01 5 71559982 71560237 256 + 1.514 1.688 0.593
ENSG00000145734 E061 59.9442502 0.0004119442 9.037428e-01 9.427559e-01 5 71562274 71562520 247 + 1.481 1.624 0.491
ENSG00000145734 E062 11.1047807 0.0014863262 7.700191e-01 8.515125e-01 5 71562775 71562895 121 + 0.814 0.882 0.265
ENSG00000145734 E063 491.3334370 0.0124306113 2.239060e-24 2.304092e-22 5 71564754 71567820 3067 + 2.318 2.904 1.951