ENSG00000145730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348126 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 5.3549281 4.0276110 5.1764666 0.7032094 0.22855227 0.3612501 0.23901667 0.18883333 0.217433333 0.02860000 7.478110e-01 1.947704e-36 FALSE TRUE
ENST00000379799 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 4.3193893 5.3242605 3.8349397 0.7457464 0.43667167 -0.4723273 0.19667917 0.24753333 0.160966667 -0.08656667 7.837160e-02 1.947704e-36 FALSE TRUE
ENST00000455264 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 1.9464659 1.3437997 2.3859197 0.1198863 0.46378962 0.8235653 0.08306250 0.06400000 0.100533333 0.03653333 3.764655e-01 1.947704e-36 FALSE TRUE
ENST00000504456 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 1.3022310 3.2590893 0.0000000 0.1566442 0.00000000 -8.3527450 0.06658750 0.15413333 0.000000000 -0.15413333 1.947704e-36 1.947704e-36 FALSE TRUE
ENST00000504691 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 1.7625406 2.8484588 0.9255625 0.1816883 0.07223117 -1.6113316 0.08397917 0.13393333 0.038933333 -0.09500000 1.154464e-11 1.947704e-36 FALSE TRUE
ENST00000510006 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 0.7177439 1.7423751 0.1221990 0.7793564 0.06686223 -3.7285282 0.03482917 0.07833333 0.005166667 -0.07316667 4.299039e-03 1.947704e-36 FALSE FALSE
ENST00000682882 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 1.5109834 0.5540805 1.6210291 0.5540805 0.72985589 1.5318096 0.07017500 0.02886667 0.068166667 0.03930000 2.417457e-01 1.947704e-36 FALSE TRUE
ENST00000682972 ENSG00000145730 HEK293_OSMI2_2hA HEK293_TMG_2hB PAM protein_coding protein_coding 22.22692 21.3059 23.80969 1.324613 0.2314536 0.1602248 1.9346547 0.3512630 3.7893643 0.2774027 0.30913698 3.3946365 0.08100833 0.01700000 0.159400000 0.14240000 3.370849e-02 1.947704e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145730 E001 0.0000000       5 102753981 102754090 110 +      
ENSG00000145730 E002 0.1472490 0.0434199462 6.359196e-01   5 102754667 102754723 57 + 0.108 0.000 -10.453
ENSG00000145730 E003 0.1472490 0.0434199462 6.359196e-01   5 102754724 102754782 59 + 0.108 0.000 -12.695
ENSG00000145730 E004 0.1472490 0.0434199462 6.359196e-01   5 102754783 102754790 8 + 0.108 0.000 -12.695
ENSG00000145730 E005 0.4396707 0.0272754003 1.390703e-01 2.467979e-01 5 102754791 102754945 155 + 0.267 0.000 -14.491
ENSG00000145730 E006 4.3847656 0.0042909903 1.364663e-04 6.878544e-04 5 102754946 102755254 309 + 0.922 0.327 -2.713
ENSG00000145730 E007 7.2278089 0.0025272572 1.892875e-02 4.917643e-02 5 102755255 102755297 43 + 1.026 0.740 -1.100
ENSG00000145730 E008 6.4634512 0.0026135737 3.415299e-02 8.005570e-02 5 102755298 102755304 7 + 0.977 0.709 -1.045
ENSG00000145730 E009 9.8892522 0.0088494835 3.399207e-03 1.143534e-02 5 102755305 102755313 9 + 1.164 0.821 -1.273
ENSG00000145730 E010 11.9134258 0.0453261204 1.386334e-02 3.791604e-02 5 102755314 102755321 8 + 1.241 0.892 -1.273
ENSG00000145730 E011 22.7953533 0.0406804798 1.595319e-02 4.262562e-02 5 102755322 102755342 21 + 1.492 1.195 -1.033
ENSG00000145730 E012 22.3148845 0.0335442287 1.056065e-02 3.011308e-02 5 102755343 102755348 6 + 1.484 1.185 -1.044
ENSG00000145730 E013 0.0000000       5 102755349 102755469 121 +      
ENSG00000145730 E014 0.0000000       5 102808057 102808062 6 +      
ENSG00000145730 E015 0.0000000       5 102808063 102808231 169 +      
ENSG00000145730 E016 0.0000000       5 102837687 102837792 106 +      
ENSG00000145730 E017 0.1482932 0.0411197135 3.743253e-01   5 102838221 102838589 369 + 0.000 0.138 12.303
ENSG00000145730 E018 0.0000000       5 102864537 102864567 31 +      
ENSG00000145730 E019 0.0000000       5 102865244 102865272 29 +      
ENSG00000145730 E020 0.0000000       5 102865310 102865467 158 +      
ENSG00000145730 E021 0.1817044 0.0403421306 3.718222e-01   5 102865479 102865510 32 + 0.000 0.138 12.315
ENSG00000145730 E022 0.4407149 0.0214807050 7.414676e-01 8.306319e-01 5 102865737 102865818 82 + 0.195 0.138 -0.599
ENSG00000145730 E023 0.4407149 0.0214807050 7.414676e-01 8.306319e-01 5 102865819 102865822 4 + 0.195 0.138 -0.599
ENSG00000145730 E024 107.3593834 0.0225358144 6.453856e-05 3.536265e-04 5 102865823 102866284 462 + 2.161 1.835 -1.096
ENSG00000145730 E025 0.1515154 0.0432623870 6.357644e-01   5 102866587 102866716 130 + 0.108 0.000 -12.697
ENSG00000145730 E026 104.4656364 0.0021967698 2.679917e-14 8.272318e-13 5 102867273 102867393 121 + 2.150 1.825 -1.091
ENSG00000145730 E027 1.4864579 0.1113076763 8.939492e-01 9.361806e-01 5 102873293 102873804 512 + 0.384 0.398 0.082
ENSG00000145730 E028 1.0298247 0.0118775445 1.043792e-01 1.971596e-01 5 102895913 102895962 50 + 0.431 0.138 -2.183
ENSG00000145730 E029 0.3289534 0.0299769629 8.375705e-01   5 102899936 102900002 67 + 0.108 0.138 0.403
ENSG00000145730 E030 91.5739202 0.0003325640 3.595457e-18 1.847934e-16 5 102901356 102901413 58 + 2.097 1.757 -1.144
ENSG00000145730 E031 104.8424420 0.0002679297 1.311802e-12 3.155370e-11 5 102913934 102914021 88 + 2.127 1.873 -0.852
ENSG00000145730 E032 89.1107126 0.0003542141 3.162793e-07 2.912324e-06 5 102924957 102925042 86 + 2.037 1.839 -0.663
ENSG00000145730 E033 86.5960512 0.0085685805 7.564761e-04 3.102666e-03 5 102926585 102926668 84 + 2.026 1.821 -0.690
ENSG00000145730 E034 63.5538305 0.0004172872 3.666516e-06 2.692080e-05 5 102946837 102946885 49 + 1.897 1.686 -0.712
ENSG00000145730 E035 72.3184457 0.0027184215 3.658894e-03 1.217962e-02 5 102948378 102948445 68 + 1.927 1.784 -0.479
ENSG00000145730 E036 60.9528440 0.0003941474 1.616562e-02 4.309051e-02 5 102949537 102949576 40 + 1.840 1.730 -0.371
ENSG00000145730 E037 68.1465413 0.0003729261 5.373001e-04 2.299505e-03 5 102949577 102949617 41 + 1.904 1.754 -0.508
ENSG00000145730 E038 96.9191954 0.0014632525 3.598831e-04 1.618411e-03 5 102949902 102949978 77 + 2.054 1.909 -0.486
ENSG00000145730 E039 102.3589185 0.0002960176 1.946698e-04 9.411906e-04 5 102950717 102950820 104 + 2.074 1.942 -0.443
ENSG00000145730 E040 121.4872021 0.0002404344 7.148469e-04 2.951864e-03 5 102959875 102959996 122 + 2.137 2.027 -0.368
ENSG00000145730 E041 103.7139135 0.0003778630 2.406318e-01 3.749067e-01 5 102959997 102960059 63 + 2.039 1.997 -0.140
ENSG00000145730 E042 99.5391620 0.0003931243 1.946667e-01 3.195784e-01 5 102961158 102961229 72 + 2.024 1.977 -0.158
ENSG00000145730 E043 93.4080776 0.0064088456 7.777134e-01 8.569703e-01 5 102974116 102974298 183 + 1.969 1.981 0.041
ENSG00000145730 E044 69.7661514 0.0066179884 4.164942e-01 5.598461e-01 5 102974299 102974390 92 + 1.828 1.872 0.148
ENSG00000145730 E045 57.5274574 0.0086703214 5.819718e-01 7.064272e-01 5 102974391 102974436 46 + 1.752 1.782 0.103
ENSG00000145730 E046 2.6498125 0.0065453464 9.523438e-01 9.741513e-01 5 102974437 102974837 401 + 0.550 0.559 0.041
ENSG00000145730 E047 0.6299079 0.0232624479 4.632157e-01 6.030472e-01 5 102989771 102990271 501 + 0.267 0.138 -1.182
ENSG00000145730 E048 151.4233364 0.0002140176 6.465202e-02 1.344648e-01 5 102990272 102990401 130 + 2.208 2.155 -0.179
ENSG00000145730 E049 149.0840179 0.0002221282 3.107325e-02 7.405256e-02 5 103003033 103003149 117 + 2.205 2.142 -0.211
ENSG00000145730 E050 107.5608745 0.0005813766 7.179132e-01 8.131685e-01 5 103005154 103005226 73 + 2.028 2.040 0.040
ENSG00000145730 E051 190.5692884 0.0001886182 3.385907e-01 4.824709e-01 5 103006801 103007006 206 + 2.272 2.297 0.082
ENSG00000145730 E052 70.8422831 0.0003625974 6.156381e-01 7.338655e-01 5 103007007 103007011 5 + 1.869 1.849 -0.070
ENSG00000145730 E053 150.3008332 0.0079946168 1.916061e-01 3.157716e-01 5 103007457 103007558 102 + 2.147 2.220 0.245
ENSG00000145730 E054 91.0197304 0.0103147666 1.425089e-01 2.514471e-01 5 103007559 103007568 10 + 1.919 2.017 0.327
ENSG00000145730 E055 139.4568588 0.0080839015 4.315449e-02 9.682698e-02 5 103007569 103007657 89 + 2.094 2.206 0.375
ENSG00000145730 E056 156.9796122 0.0023723086 6.858912e-06 4.733390e-05 5 103009751 103009866 116 + 2.116 2.279 0.546
ENSG00000145730 E057 160.5414363 0.0002568756 4.601601e-08 4.999133e-07 5 103017334 103017433 100 + 2.130 2.284 0.513
ENSG00000145730 E058 157.3193782 0.0002589178 1.871536e-08 2.194040e-07 5 103019790 103019843 54 + 2.118 2.278 0.533
ENSG00000145730 E059 49.0416312 0.0009673351 4.650102e-02 1.029433e-01 5 103025131 103025133 3 + 1.647 1.748 0.345
ENSG00000145730 E060 152.5348427 0.0002343513 3.040439e-07 2.810177e-06 5 103025134 103025334 201 + 2.112 2.259 0.491
ENSG00000145730 E061 49.2325658 0.0004775148 2.735415e-01 4.125860e-01 5 103028182 103028184 3 + 1.679 1.733 0.185
ENSG00000145730 E062 141.5117048 0.0006513768 1.708232e-06 1.349032e-05 5 103028185 103028238 54 + 2.080 2.230 0.502
ENSG00000145730 E063 507.1538052 0.0003186129 4.291428e-41 1.584792e-38 5 103028887 103029730 844 + 2.588 2.811 0.743