ENSG00000145725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321521 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding protein_coding 10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 0.05118143 0.0708496 0.07713972 0.07084960 0.07713972 0.1080898 0.01200000 0.07823333 0.003666667 -0.074566667 0.578216849 0.009259744 FALSE TRUE
ENST00000509597 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding protein_coding 10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 0.60608117 0.2029907 0.93167571 0.10401479 0.12895121 2.1444399 0.09752083 0.17196667 0.043866667 -0.128100000 0.387478465 0.009259744 FALSE TRUE
ENST00000511022 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding protein_coding 10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 0.91687921 0.2052110 2.17814349 0.20521097 0.53365592 3.3458838 0.10627083 0.10546667 0.102800000 -0.002666667 0.731930013 0.009259744 FALSE TRUE
MSTRG.26683.6 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding   10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 0.38649946 0.1213239 0.37369198 0.07644428 0.19887730 1.5468195 0.07165833 0.11326667 0.017566667 -0.095700000 0.619684464 0.009259744 FALSE TRUE
MSTRG.26683.7 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding   10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 4.80108174 0.1117988 9.73324540 0.11179877 0.80755481 6.3218310 0.29292083 0.05746667 0.458766667 0.401300000 0.009259744 0.009259744 FALSE TRUE
MSTRG.26683.8 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding   10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 0.03498107 0.1031185 0.00000000 0.10311848 0.00000000 -3.4997627 0.02835417 0.11300000 0.000000000 -0.113000000 0.329877736 0.009259744 FALSE TRUE
MSTRG.26683.9 ENSG00000145725 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K2 protein_coding   10.87957 1.254596 21.22171 0.345466 0.1363256 4.069472 1.75160493 0.1718392 2.53569323 0.09122460 0.23641662 3.8073233 0.15257917 0.18886667 0.119400000 -0.069466667 0.962268810 0.009259744 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145725 E001 0.0000000       5 103120149 103120194 46 +      
ENSG00000145725 E002 0.1472490 0.0442691482 4.863584e-01   5 103120200 103120253 54 + 0.033 0.000 -7.744
ENSG00000145725 E003 0.4460135 0.0423764391 1.000000e+00 1.000000e+00 5 103120254 103120261 8 + 0.092 0.000 -9.296
ENSG00000145725 E004 0.8962933 0.1421627972 1.000000e+00 1.000000e+00 5 103120262 103120271 10 + 0.169 0.000 -10.299
ENSG00000145725 E005 1.1866387 0.0109479849 6.946786e-01 7.954450e-01 5 103120272 103120284 13 + 0.213 0.000 -10.711
ENSG00000145725 E006 3.8743353 0.0552271678 4.940058e-01 6.310327e-01 5 103120285 103120300 16 + 0.473 0.370 -0.555
ENSG00000145725 E007 31.1220281 0.0006610764 2.104106e-01 3.390230e-01 5 103120301 103120389 89 + 1.219 1.198 -0.075
ENSG00000145725 E008 46.2736528 0.0004689485 3.360985e-02 7.898682e-02 5 103120390 103120488 99 + 1.387 1.296 -0.315
ENSG00000145725 E009 0.0000000       5 103120608 103120838 231 +      
ENSG00000145725 E010 88.7799083 0.0003398488 6.084632e-02 1.280638e-01 5 103129306 103129703 398 + 1.657 1.656 -0.003
ENSG00000145725 E011 42.1592455 0.0005219619 3.430902e-01 4.871456e-01 5 103133453 103133548 96 + 1.341 1.377 0.125
ENSG00000145725 E012 38.6944337 0.0005277407 2.438388e-03 8.576778e-03 5 103133549 103133648 100 + 1.320 1.069 -0.890
ENSG00000145725 E013 2.0765893 0.0081851086 3.041324e-01 4.461402e-01 5 103135993 103136114 122 + 0.323 0.000 -11.518
ENSG00000145725 E014 47.5474537 0.0004774492 1.041384e-04 5.411202e-04 5 103136732 103136822 91 + 1.407 1.069 -1.193
ENSG00000145725 E015 42.4823731 0.0022268580 8.378591e-04 3.394389e-03 5 103138384 103138469 86 + 1.359 1.070 -1.025
ENSG00000145725 E016 60.6640873 0.0024368976 1.393842e-04 7.009240e-04 5 103146527 103146681 155 + 1.507 1.233 -0.952
ENSG00000145725 E017 54.5691333 0.0041933339 1.643592e-04 8.108265e-04 5 103147931 103148032 102 + 1.465 1.159 -1.069
ENSG00000145725 E018 0.0000000       5 103148152 103148300 149 +      
ENSG00000145725 E019 64.9018467 0.0105070346 2.154188e-02 5.472991e-02 5 103149152 103149313 162 + 1.529 1.424 -0.361
ENSG00000145725 E020 61.7875166 0.0060960354 7.347362e-02 1.490849e-01 5 103151253 103151374 122 + 1.504 1.466 -0.132
ENSG00000145725 E021 58.3389683 0.0035550191 4.325496e-05 2.474191e-04 5 103152648 103152749 102 + 1.493 1.159 -1.166
ENSG00000145725 E022 60.9735035 0.0003782001 1.888907e-08 2.212761e-07 5 103153848 103153934 87 + 1.518 0.957 -1.989
ENSG00000145725 E023 48.3843392 0.0004715338 7.002408e-05 3.801430e-04 5 103154670 103154745 76 + 1.417 1.069 -1.226
ENSG00000145725 E024 51.5849071 0.0016093420 6.937635e-06 4.782977e-05 5 103154834 103154943 110 + 1.446 1.017 -1.519
ENSG00000145725 E025 28.9609872 0.0006538994 5.458863e-02 1.172709e-01 5 103155909 103155994 86 + 1.195 1.069 -0.452
ENSG00000145725 E026 44.2369311 0.0033615804 1.573645e-04 7.800164e-04 5 103158188 103158313 126 + 1.379 1.017 -1.289
ENSG00000145725 E027 20.8993366 0.0009778486 1.097117e-04 5.666451e-04 5 103158452 103158454 3 + 1.081 0.370 -3.042
ENSG00000145725 E028 48.4500723 0.0004973739 9.466266e-03 2.745282e-02 5 103158455 103158573 119 + 1.409 1.266 -0.497
ENSG00000145725 E029 64.8176628 0.0016509538 4.956112e-02 1.083828e-01 5 103159146 103159328 183 + 1.525 1.485 -0.139
ENSG00000145725 E030 64.2726054 0.0004035589 1.057989e-03 4.159740e-03 5 103167179 103167320 142 + 1.528 1.352 -0.610
ENSG00000145725 E031 33.4047959 0.0024333812 1.398553e-04 7.029572e-04 5 103168072 103168079 8 + 1.266 0.804 -1.701
ENSG00000145725 E032 58.6287786 0.0006778132 4.913023e-04 2.127349e-03 5 103168080 103168187 108 + 1.490 1.266 -0.778
ENSG00000145725 E033 44.2198363 0.0038162943 9.781515e-01 9.904653e-01 5 103168188 103168295 108 + 1.350 1.485 0.465
ENSG00000145725 E034 45.4454834 0.0004892455 7.361157e-01 8.267032e-01 5 103173155 103173253 99 + 1.359 1.521 0.559
ENSG00000145725 E035 27.7165269 0.0099849170 1.023676e-01 1.941303e-01 5 103173254 103173282 29 + 1.177 1.069 -0.389
ENSG00000145725 E036 22.9719346 0.0123630739 3.091005e-01 4.513744e-01 5 103173858 103173862 5 + 1.098 1.069 -0.103
ENSG00000145725 E037 45.8627115 0.0017686811 2.853267e-01 4.256347e-01 5 103173863 103173946 84 + 1.375 1.401 0.087
ENSG00000145725 E038 38.7886360 0.0006153786 5.755662e-01 7.011477e-01 5 103173947 103173972 26 + 1.303 1.377 0.256
ENSG00000145725 E039 0.8846520 0.0136747766 4.324552e-01 5.749004e-01 5 103173973 103174191 219 + 0.144 0.369 1.764
ENSG00000145725 E040 6.7741651 0.0025313163 4.096302e-01 5.532338e-01 5 103176866 103176910 45 + 0.643 0.566 -0.339
ENSG00000145725 E041 75.0007443 0.0015870592 3.708988e-01 5.153180e-01 5 103177667 103177774 108 + 1.578 1.643 0.220
ENSG00000145725 E042 59.2142062 0.0104957301 7.230005e-01 8.169436e-01 5 103177864 103177918 55 + 1.475 1.573 0.334
ENSG00000145725 E043 54.9825833 0.0007402730 8.553793e-01 9.105791e-01 5 103177919 103177980 62 + 1.438 1.586 0.507
ENSG00000145725 E044 75.1170188 0.0034294209 4.319673e-01 5.744535e-01 5 103180021 103180188 168 + 1.566 1.760 0.657
ENSG00000145725 E045 20.9577437 0.0207168293 3.112370e-01 4.536833e-01 5 103183234 103183407 174 + 1.033 1.297 0.942
ENSG00000145725 E046 2.3993138 0.0060979598 8.639088e-01 9.162487e-01 5 103184243 103184671 429 + 0.339 0.370 0.181
ENSG00000145725 E047 48.4451211 0.0009756899 1.426794e-01 2.516707e-01 5 103184672 103184744 73 + 1.375 1.630 0.873
ENSG00000145725 E048 39.0832641 0.0011292037 7.517010e-01 8.380806e-01 5 103186320 103186439 120 + 1.301 1.401 0.345
ENSG00000145725 E049 13.7192841 0.0013634940 7.720238e-01 8.528687e-01 5 103187314 103187376 63 + 0.883 0.957 0.281
ENSG00000145725 E050 2.8086818 0.0167405588 1.792142e-01 3.001492e-01 5 103188591 103189166 576 + 0.398 0.000 -11.959
ENSG00000145725 E051 1.1866387 0.0109479849 6.946786e-01 7.954450e-01 5 103189167 103189226 60 + 0.213 0.000 -10.711
ENSG00000145725 E052 63.8715247 0.0003775053 5.271379e-01 6.602854e-01 5 103190842 103190982 141 + 1.500 1.681 0.617
ENSG00000145725 E053 0.5964967 0.0211393170 2.464515e-01 3.817933e-01 5 103190983 103191058 76 + 0.092 0.369 2.500
ENSG00000145725 E054 0.5933762 0.0203835616 1.000000e+00 1.000000e+00 5 103194781 103194899 119 + 0.119 0.000 -9.711
ENSG00000145725 E055 66.0082039 0.0025766742 1.897437e-01 3.134412e-01 5 103194900 103195025 126 + 1.507 1.739 0.790
ENSG00000145725 E056 55.8667431 0.0009392342 1.957431e-03 7.093548e-03 5 103201522 103201675 154 + 1.419 1.779 1.226
ENSG00000145725 E057 275.2340614 0.0500037354 7.529213e-09 9.492159e-08 5 103201676 103211914 10239 + 2.041 2.728 2.293
ENSG00000145725 E058 9.1602897 0.0018743198 3.958852e-10 6.319985e-09 5 103211915 103212799 885 + 0.585 1.465 3.310