ENSG00000145715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274376 ENSG00000145715 HEK293_OSMI2_2hA HEK293_TMG_2hB RASA1 protein_coding protein_coding 5.146588 2.100929 8.005857 0.07546026 0.4806425 1.924978 3.0931683 0.7667621 5.229667 0.07558016 0.4194383 2.7539305 0.5798583 0.3670000 0.6552667 0.2882667 0.008425339 0.008425339 FALSE TRUE
ENST00000456692 ENSG00000145715 HEK293_OSMI2_2hA HEK293_TMG_2hB RASA1 protein_coding protein_coding 5.146588 2.100929 8.005857 0.07546026 0.4806425 1.924978 1.3723630 1.3001374 2.270104 0.14108805 0.5343164 0.7993818 0.3088042 0.6161667 0.2871667 -0.3290000 0.016908335 0.008425339 FALSE TRUE
ENST00000509953 ENSG00000145715 HEK293_OSMI2_2hA HEK293_TMG_2hB RASA1 protein_coding retained_intron 5.146588 2.100929 8.005857 0.07546026 0.4806425 1.924978 0.4725307 0.0000000 0.440516 0.00000000 0.4405160 5.4935065 0.0517750 0.0000000 0.0496000 0.0496000 1.000000000 0.008425339 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145715 E001 0.4502799 0.0310117703 5.348840e-01 6.668661e-01 5 87267883 87267887 5 + 0.177 0.000 -10.328
ENSG00000145715 E002 63.7539439 0.0004248229 6.576247e-04 2.743400e-03 5 87267888 87268932 1045 + 1.781 1.618 -0.552
ENSG00000145715 E003 15.7654609 0.0076655158 2.154712e-01 3.449852e-01 5 87268933 87268943 11 + 1.187 1.071 -0.417
ENSG00000145715 E004 22.7158904 0.0040648337 4.298823e-02 9.652251e-02 5 87268944 87268990 47 + 1.344 1.174 -0.595
ENSG00000145715 E005 0.0000000       5 87268991 87269055 65 +      
ENSG00000145715 E006 0.0000000       5 87269161 87269287 127 +      
ENSG00000145715 E007 0.0000000       5 87330938 87330983 46 +      
ENSG00000145715 E008 34.9578237 0.0006456937 8.573852e-03 2.522386e-02 5 87331348 87331500 153 + 1.524 1.353 -0.592
ENSG00000145715 E009 38.1588971 0.0006101493 1.471250e-02 3.984275e-02 5 87332507 87332642 136 + 1.558 1.410 -0.509
ENSG00000145715 E010 33.0688961 0.0007599168 2.319687e-02 5.815768e-02 5 87333267 87333337 71 + 1.500 1.353 -0.509
ENSG00000145715 E011 0.0000000       5 87337972 87337973 2 +      
ENSG00000145715 E012 32.9194383 0.0057341919 6.900106e-01 7.918132e-01 5 87337974 87338091 118 + 1.469 1.460 -0.032
ENSG00000145715 E013 23.0026192 0.0014607064 8.435415e-01 9.025755e-01 5 87341290 87341321 32 + 1.303 1.341 0.132
ENSG00000145715 E014 23.2283479 0.0029991121 6.129371e-01 7.317678e-01 5 87346672 87346724 53 + 1.324 1.301 -0.079
ENSG00000145715 E015 42.3744008 0.0082710571 2.209316e-01 3.515529e-01 5 87349214 87349364 151 + 1.589 1.514 -0.255
ENSG00000145715 E016 35.9140890 0.0005971041 3.710017e-01 5.154088e-01 5 87353157 87353235 79 + 1.509 1.470 -0.135
ENSG00000145715 E017 36.6545355 0.0012966987 8.279014e-01 8.918197e-01 5 87362551 87362671 121 + 1.507 1.514 0.025
ENSG00000145715 E018 42.3639179 0.0005178004 6.810571e-02 1.402254e-01 5 87363348 87363504 157 + 1.593 1.497 -0.328
ENSG00000145715 E019 0.6017953 0.1683411192 4.098145e-01 5.534432e-01 5 87366351 87366495 145 + 0.223 0.000 -10.742
ENSG00000145715 E020 26.9378014 0.0007731215 1.173363e-01 2.161451e-01 5 87369813 87369900 88 + 1.405 1.301 -0.363
ENSG00000145715 E021 0.1451727 0.0428733210 1.000000e+00   5 87369901 87369901 1 + 0.067 0.000 -8.737
ENSG00000145715 E022 30.1520514 0.0006665707 2.014025e-02 5.177854e-02 5 87372118 87372195 78 + 1.461 1.301 -0.557
ENSG00000145715 E023 37.5961443 0.0006191566 3.501977e-01 4.943991e-01 5 87374163 87374320 158 + 1.529 1.488 -0.140
ENSG00000145715 E024 19.7181531 0.0041390031 7.861545e-01 8.630388e-01 5 87374840 87374916 77 + 1.240 1.287 0.164
ENSG00000145715 E025 37.6945020 0.0012463565 9.892416e-01 9.973115e-01 5 87376393 87376565 173 + 1.516 1.539 0.079
ENSG00000145715 E026 44.8961620 0.0007200862 7.746742e-01 8.547805e-01 5 87376881 87377040 160 + 1.585 1.625 0.135
ENSG00000145715 E027 44.7394181 0.0009269635 3.307574e-01 4.743309e-01 5 87378396 87378538 143 + 1.570 1.650 0.274
ENSG00000145715 E028 35.7153139 0.0005713652 9.849088e-01 9.946028e-01 5 87379735 87379850 116 + 1.491 1.514 0.080
ENSG00000145715 E029 36.2238718 0.0005668190 7.789369e-01 8.577930e-01 5 87380509 87380595 87 + 1.502 1.506 0.012
ENSG00000145715 E030 34.2076923 0.0021785401 1.122657e-01 2.088516e-01 5 87383713 87383780 68 + 1.446 1.577 0.448
ENSG00000145715 E031 39.1515060 0.0018407183 3.913832e-01 5.352911e-01 5 87385301 87385389 89 + 1.520 1.598 0.266
ENSG00000145715 E032 41.3523264 0.0005119856 2.836015e-01 4.237415e-01 5 87386826 87386903 78 + 1.537 1.625 0.299
ENSG00000145715 E033 0.1482932 0.0415238647 1.237918e-01   5 87389303 87389392 90 + 0.000 0.213 12.300
ENSG00000145715 E034 44.3619160 0.0005693823 2.630480e-01 4.009112e-01 5 87389393 87389527 135 + 1.568 1.656 0.301
ENSG00000145715 E035 142.2561584 0.0083381295 9.522192e-08 9.705858e-07 5 87390800 87391931 1132 + 2.002 2.286 0.951