ENSG00000145703

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274364 ENSG00000145703 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP2 protein_coding protein_coding 3.978672 1.968631 5.825956 0.3397181 0.2894957 1.560466 1.7316546 0.2846338 3.1128437 0.1213103 0.3117141 3.40586567 0.37510833 0.1373667 0.54003333 0.40266667 6.938752e-03 5.743106e-13 FALSE TRUE
ENST00000379730 ENSG00000145703 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP2 protein_coding protein_coding 3.978672 1.968631 5.825956 0.3397181 0.2894957 1.560466 1.2162800 0.2883340 1.6277980 0.1494669 0.3671860 2.45675693 0.26749583 0.1754667 0.27496667 0.09950000 6.948912e-01 5.743106e-13 FALSE TRUE
ENST00000504477 ENSG00000145703 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP2 protein_coding nonsense_mediated_decay 3.978672 1.968631 5.825956 0.3397181 0.2894957 1.560466 0.4063247 0.8566594 0.0000000 0.0455318 0.0000000 -6.43739314 0.22386667 0.4649667 0.00000000 -0.46496667 5.743106e-13 5.743106e-13 FALSE TRUE
ENST00000512256 ENSG00000145703 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP2 protein_coding retained_intron 3.978672 1.968631 5.825956 0.3397181 0.2894957 1.560466 0.3326676 0.2895562 0.2990068 0.2895562 0.2990068 0.04481205 0.06318333 0.1097333 0.04956667 -0.06016667 8.879800e-01 5.743106e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145703 E001 4.1425695 0.0057771460 2.694786e-03 9.358393e-03 5 76403285 76403344 60 + 0.705 0.000 -14.070
ENSG00000145703 E002 11.6545479 0.0094730573 1.034345e-02 2.961276e-02 5 76403345 76403591 247 + 1.059 0.667 -1.520
ENSG00000145703 E003 0.2965864 0.4512729611 3.971702e-02   5 76404424 76404531 108 + 0.000 0.380 14.573
ENSG00000145703 E004 11.0280247 0.0015703753 1.793932e-01 3.003584e-01 5 76461570 76461669 100 + 1.013 0.834 -0.675
ENSG00000145703 E005 0.3268771 0.0286571632 2.444992e-01   5 76461670 76463094 1425 + 0.059 0.238 2.325
ENSG00000145703 E006 0.0000000       5 76547409 76547451 43 +      
ENSG00000145703 E007 16.7992326 0.0011232087 1.873716e-02 4.875758e-02 5 76562396 76562552 157 + 1.195 0.918 -1.011
ENSG00000145703 E008 16.4529861 0.0021096445 1.048832e-02 2.995058e-02 5 76570580 76570657 78 + 1.191 0.878 -1.149
ENSG00000145703 E009 17.0842919 0.0041791569 7.858604e-03 2.342521e-02 5 76575693 76575769 77 + 1.207 0.878 -1.205
ENSG00000145703 E010 15.9667808 0.0010766546 5.353364e-03 1.689256e-02 5 76588906 76588973 68 + 1.183 0.834 -1.290
ENSG00000145703 E011 17.9204745 0.0012809102 1.028434e-03 4.056668e-03 5 76589615 76589728 114 + 1.238 0.834 -1.483
ENSG00000145703 E012 20.0324455 0.0049476865 5.495936e-02 1.179216e-01 5 76590408 76590586 179 + 1.259 1.049 -0.751
ENSG00000145703 E013 13.1020947 0.0149699268 2.306477e-01 3.632304e-01 5 76592838 76592925 88 + 1.081 0.919 -0.598
ENSG00000145703 E014 0.0000000       5 76597074 76597438 365 +      
ENSG00000145703 E015 20.5917015 0.0009535713 2.606362e-01 3.981961e-01 5 76597439 76597602 164 + 1.259 1.149 -0.388
ENSG00000145703 E016 23.4863596 0.0008271618 1.860119e-01 3.087574e-01 5 76600812 76600972 161 + 1.314 1.192 -0.431
ENSG00000145703 E017 13.3137671 0.0013038723 3.882134e-02 8.885141e-02 5 76606179 76606199 21 + 1.101 0.834 -0.997
ENSG00000145703 E018 17.6702046 0.0012352791 4.658648e-02 1.030952e-01 5 76606200 76606303 104 + 1.211 0.989 -0.805
ENSG00000145703 E019 0.0000000       5 76609095 76609118 24 +      
ENSG00000145703 E020 0.0000000       5 76609119 76609124 6 +      
ENSG00000145703 E021 0.0000000       5 76609125 76609137 13 +      
ENSG00000145703 E022 0.0000000       5 76609138 76609138 1 +      
ENSG00000145703 E023 0.0000000       5 76609139 76609179 41 +      
ENSG00000145703 E024 0.0000000       5 76609180 76609230 51 +      
ENSG00000145703 E025 20.1285148 0.0009335362 2.146436e-02 5.456880e-02 5 76611020 76611183 164 + 1.266 1.020 -0.882
ENSG00000145703 E026 0.0000000       5 76618514 76618600 87 +      
ENSG00000145703 E027 0.0000000       5 76624304 76624485 182 +      
ENSG00000145703 E028 16.4677468 0.0011036266 4.823148e-02 1.060468e-01 5 76627410 76627500 91 + 1.183 0.955 -0.831
ENSG00000145703 E029 0.1472490 0.0430193339 1.000000e+00   5 76628685 76628752 68 + 0.059 0.000 -9.259
ENSG00000145703 E030 26.4045632 0.0007542802 1.489854e-02 4.025793e-02 5 76631859 76632026 168 + 1.377 1.150 -0.800
ENSG00000145703 E031 0.0000000       5 76632027 76632785 759 +      
ENSG00000145703 E032 11.9941475 0.0014755494 3.165221e-01 4.593031e-01 5 76637034 76637040 7 + 1.043 0.918 -0.462
ENSG00000145703 E033 24.4363144 0.0104233423 1.172880e-01 2.160729e-01 5 76637041 76637176 136 + 1.336 1.172 -0.577
ENSG00000145703 E034 22.0907623 0.0279915363 3.535084e-01 4.977525e-01 5 76640933 76641103 171 + 1.287 1.171 -0.408
ENSG00000145703 E035 13.6672987 0.0281756242 4.741698e-01 6.130211e-01 5 76652750 76652833 84 + 1.092 0.988 -0.381
ENSG00000145703 E036 11.8156785 0.0014316055 1.041932e-01 1.968829e-01 5 76654200 76654271 72 + 1.048 0.834 -0.804
ENSG00000145703 E037 11.8037966 0.0025045580 2.030256e-01 3.300037e-01 5 76654934 76654968 35 + 1.043 0.878 -0.614
ENSG00000145703 E038 14.0708506 0.0012739471 1.032692e-01 1.954488e-01 5 76654969 76655003 35 + 1.116 0.918 -0.728
ENSG00000145703 E039 33.2511092 0.0006564322 2.796997e-02 6.795284e-02 5 76658459 76658667 209 + 1.463 1.284 -0.624
ENSG00000145703 E040 0.1515154 0.0428215648 1.000000e+00   5 76660028 76660325 298 + 0.059 0.000 -9.260
ENSG00000145703 E041 25.9369246 0.0012819586 3.702087e-01 5.146498e-01 5 76665026 76665175 150 + 1.344 1.267 -0.270
ENSG00000145703 E042 16.0366220 0.0011177689 6.300097e-02 1.317076e-01 5 76668681 76668757 77 + 1.171 0.955 -0.786
ENSG00000145703 E043 17.1336584 0.0085367001 3.583870e-01 5.027795e-01 5 76668758 76668844 87 + 1.179 1.077 -0.367
ENSG00000145703 E044 19.8535951 0.0009838717 9.590959e-02 1.842572e-01 5 76671759 76671869 111 + 1.249 1.077 -0.614
ENSG00000145703 E045 20.5764137 0.0009290684 8.274735e-03 2.447844e-02 5 76671870 76671983 114 + 1.276 0.989 -1.032
ENSG00000145703 E046 30.3678459 0.0006977540 7.261134e-01 8.192191e-01 5 76673449 76673589 141 + 1.398 1.373 -0.087
ENSG00000145703 E047 0.3030308 0.3732507489 1.000000e+00   5 76673590 76673781 192 + 0.111 0.000 -10.266
ENSG00000145703 E048 0.3030308 0.3732507489 1.000000e+00   5 76673851 76673951 101 + 0.111 0.000 -10.266
ENSG00000145703 E049 22.9683816 0.0055565788 7.823167e-01 8.602364e-01 5 76673952 76674036 85 + 1.269 1.301 0.112
ENSG00000145703 E050 17.2351769 0.0071855479 1.836429e-01 3.057815e-01 5 76674477 76674521 45 + 1.126 1.269 0.508
ENSG00000145703 E051 25.7127475 0.0008700887 7.788134e-02 1.560716e-01 5 76674522 76674640 119 + 1.289 1.435 0.507
ENSG00000145703 E052 19.1558736 0.0086920986 7.693379e-01 8.510181e-01 5 76674641 76674709 69 + 1.199 1.232 0.117
ENSG00000145703 E053 0.5159433 0.2067121956 4.711849e-01 6.103310e-01 5 76677154 76677217 64 + 0.111 0.240 1.346
ENSG00000145703 E054 25.6933530 0.0222591837 2.915184e-01 4.323911e-01 5 76677218 76677350 133 + 1.295 1.419 0.429
ENSG00000145703 E055 0.2934659 0.0307573070 2.439202e-01   5 76677351 76677542 192 + 0.059 0.237 2.322
ENSG00000145703 E056 22.7993143 0.0107299666 1.335212e-01 2.390329e-01 5 76683115 76683217 103 + 1.237 1.389 0.531
ENSG00000145703 E057 30.3012356 0.0007779927 1.043041e-02 2.981823e-02 5 76683776 76683917 142 + 1.347 1.538 0.659
ENSG00000145703 E058 31.4815698 0.0006598316 8.440789e-03 2.488728e-02 5 76693355 76693442 88 + 1.364 1.556 0.662
ENSG00000145703 E059 45.1611294 0.0005823673 1.645601e-02 4.374067e-02 5 76695454 76695666 213 + 1.528 1.678 0.512
ENSG00000145703 E060 29.8872614 0.0023667007 1.032342e-02 2.956480e-02 5 76697987 76698147 161 + 1.341 1.538 0.681
ENSG00000145703 E061 21.5818484 0.0051798739 3.764278e-02 8.665967e-02 5 76701076 76701213 138 + 1.207 1.400 0.673
ENSG00000145703 E062 0.0000000       5 76701707 76701930 224 +      
ENSG00000145703 E063 17.4692665 0.0023669146 2.726160e-04 1.268327e-03 5 76702482 76702590 109 + 1.076 1.412 1.185
ENSG00000145703 E064 0.2955422 0.0317227801 2.439648e-01   5 76702591 76702699 109 + 0.059 0.237 2.322
ENSG00000145703 E065 68.9964625 0.0013297100 1.124766e-25 1.310477e-23 5 76707200 76708132 933 + 1.599 2.081 1.628