ENSG00000145675

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336483 ENSG00000145675 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3R1 protein_coding protein_coding 3.940026 1.629362 6.297763 0.1730812 0.1552905 1.943994 0.1218854 0.0000000 0.04551582 0.00000000 0.04551582 2.472899 0.05521250 0.0000000 0.007033333 0.007033333 1.000000e+00 1.964869e-36 FALSE TRUE
ENST00000521381 ENSG00000145675 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3R1 protein_coding protein_coding 3.940026 1.629362 6.297763 0.1730812 0.1552905 1.943994 3.0515532 0.1562948 6.04149550 0.15629478 0.28376208 5.185477 0.62895417 0.1207333 0.958266667 0.837533333 1.229659e-03 1.964869e-36 FALSE TRUE
ENST00000521657 ENSG00000145675 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3R1 protein_coding protein_coding 3.940026 1.629362 6.297763 0.1730812 0.1552905 1.943994 0.1878795 0.4518774 0.00000000 0.22649116 0.00000000 -5.529438 0.08636667 0.2515000 0.000000000 -0.251500000 5.394310e-02 1.964869e-36 FALSE TRUE
ENST00000523872 ENSG00000145675 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3R1 protein_coding protein_coding 3.940026 1.629362 6.297763 0.1730812 0.1552905 1.943994 0.3217132 0.9969209 0.00000000 0.09881499 0.00000000 -6.653807 0.18397500 0.6136333 0.000000000 -0.613633333 1.964869e-36 1.964869e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145675 E001 3.1610435 0.0202329718 6.875197e-02 1.413027e-01 5 68215756 68215775 20 + 0.597 0.235 -2.041
ENSG00000145675 E002 11.9063807 0.0029551019 9.787877e-06 6.522738e-05 5 68215776 68215949 174 + 1.097 0.386 -3.004
ENSG00000145675 E003 0.0000000       5 68215950 68215953 4 +      
ENSG00000145675 E004 0.2955422 0.0310940249 2.825126e-01   5 68217466 68217798 333 + 0.060 0.235 2.279
ENSG00000145675 E005 17.1474582 0.0071153260 1.312224e-05 8.478203e-05 5 68226290 68226436 147 + 1.237 0.661 -2.179
ENSG00000145675 E006 60.8433345 0.0043139284 2.861991e-08 3.235288e-07 5 68226437 68227009 573 + 1.747 1.380 -1.254
ENSG00000145675 E007 0.0000000       5 68239898 68239937 40 +      
ENSG00000145675 E008 24.6245924 0.0008416627 3.093581e-04 1.417579e-03 5 68273390 68273482 93 + 1.364 1.043 -1.140
ENSG00000145675 E009 0.2944980 0.4534169181 1.000000e+00   5 68273483 68273681 199 + 0.112 0.000 -9.507
ENSG00000145675 E010 22.3005215 0.0011812553 3.042162e-04 1.396517e-03 5 68273939 68274013 75 + 1.327 0.983 -1.232
ENSG00000145675 E011 28.8281921 0.0006906561 1.601716e-04 7.925619e-04 5 68279602 68279733 132 + 1.429 1.120 -1.082
ENSG00000145675 E012 0.0000000       5 68280240 68280263 24 +      
ENSG00000145675 E013 0.0000000       5 68280307 68280527 221 +      
ENSG00000145675 E014 28.5254162 0.0141300360 5.813003e-02 1.234205e-01 5 68280528 68280729 202 + 1.401 1.245 -0.543
ENSG00000145675 E015 17.5397379 0.0010540605 4.452660e-01 5.868251e-01 5 68280927 68281006 80 + 1.181 1.144 -0.133
ENSG00000145675 E016 0.5954526 0.0183125141 4.636999e-01 6.034703e-01 5 68288368 68288694 327 + 0.202 0.000 -11.433
ENSG00000145675 E017 0.5181333 0.0204203327 5.171049e-01 6.515568e-01 5 68288695 68288751 57 + 0.112 0.235 1.284
ENSG00000145675 E018 0.2987644 0.0274776980 1.000000e+00   5 68290637 68290671 35 + 0.112 0.000 -10.407
ENSG00000145675 E019 0.2987644 0.0274776980 1.000000e+00   5 68290672 68290681 10 + 0.112 0.000 -10.407
ENSG00000145675 E020 0.2987644 0.0274776980 1.000000e+00   5 68290682 68290799 118 + 0.112 0.000 -10.407
ENSG00000145675 E021 0.1515154 0.0426935548 1.000000e+00   5 68290800 68290834 35 + 0.060 0.000 -9.314
ENSG00000145675 E022 0.1451727 0.0430892936 1.000000e+00   5 68290835 68292258 1424 + 0.060 0.000 -9.310
ENSG00000145675 E023 22.6473236 0.0008968958 1.491946e-01 2.605636e-01 5 68292259 68292361 103 + 1.299 1.206 -0.326
ENSG00000145675 E024 0.0000000       5 68292486 68292523 38 +      
ENSG00000145675 E025 0.1515154 0.0426935548 1.000000e+00   5 68292568 68292682 115 + 0.060 0.000 -9.314
ENSG00000145675 E026 0.1515154 0.0426935548 1.000000e+00   5 68292683 68292729 47 + 0.060 0.000 -9.314
ENSG00000145675 E027 0.0000000       5 68292730 68293100 371 +      
ENSG00000145675 E028 23.9014225 0.0011189514 2.120801e-01 3.409939e-01 5 68293101 68293199 99 + 1.314 1.243 -0.249
ENSG00000145675 E029 0.0000000       5 68293200 68293302 103 +      
ENSG00000145675 E030 33.7326697 0.0009200792 1.021232e-02 2.928958e-02 5 68293303 68293483 181 + 1.474 1.309 -0.570
ENSG00000145675 E031 24.6216789 0.0008227971 3.321503e-02 7.822707e-02 5 68293709 68293834 126 + 1.342 1.186 -0.546
ENSG00000145675 E032 29.4239599 0.0074975999 2.693056e-01 4.078170e-01 5 68294536 68294678 143 + 1.396 1.340 -0.193
ENSG00000145675 E033 42.5221539 0.0005724390 1.521729e-01 2.646413e-01 5 68295148 68295324 177 + 1.549 1.494 -0.189
ENSG00000145675 E034 32.5481414 0.0006846637 2.550045e-01 3.917913e-01 5 68295420 68295488 69 + 1.438 1.392 -0.157
ENSG00000145675 E035 0.2944980 0.4534169181 1.000000e+00   5 68295489 68295743 255 + 0.112 0.000 -9.507
ENSG00000145675 E036 42.6388481 0.0005219647 6.964745e-01 7.968167e-01 5 68296171 68296341 171 + 1.542 1.558 0.057
ENSG00000145675 E037 420.6189503 0.0018854969 6.973582e-29 1.065614e-26 5 68297412 68301821 4410 + 2.468 2.704 0.785