ENSG00000145569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274217 ENSG00000145569 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULINL protein_coding protein_coding 3.643764 1.562378 6.17046 0.1993715 0.3953352 1.974766 0.5951881 0.3524503 1.1271886 0.06784985 0.06531932 1.649616 0.1802708 0.2225000 0.18563333 -0.03686667 0.686425547 0.007974477 FALSE TRUE
ENST00000513825 ENSG00000145569 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULINL protein_coding processed_transcript 3.643764 1.562378 6.17046 0.1993715 0.3953352 1.974766 0.1057869 0.0000000 0.3063443 0.00000000 0.17003917 4.983424 0.0162875 0.0000000 0.05153333 0.05153333 0.473065535 0.007974477   FALSE
MSTRG.25946.2 ENSG00000145569 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULINL protein_coding   3.643764 1.562378 6.17046 0.1993715 0.3953352 1.974766 2.5050434 0.8824589 4.1995724 0.10003030 0.48489789 2.237816 0.6644333 0.5673667 0.67716667 0.10980000 0.391045018 0.007974477 TRUE TRUE
MSTRG.25946.3 ENSG00000145569 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULINL protein_coding   3.643764 1.562378 6.17046 0.1993715 0.3953352 1.974766 0.4291502 0.3274692 0.4685926 0.04588813 0.08829648 0.504042 0.1376458 0.2101667 0.07473333 -0.13543333 0.007974477 0.007974477 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145569 E001 0.5975289 0.0219532869 0.2761794125 0.415591926 5 14581792 14581803 12 + 0.247 0.001 -8.610
ENSG00000145569 E002 15.0197586 0.0023075482 0.0052417499 0.016589549 5 14581804 14581958 155 + 1.238 0.941 -1.078
ENSG00000145569 E003 32.4366503 0.0032359160 0.0008999345 0.003613529 5 14600965 14601124 160 + 1.548 1.295 -0.874
ENSG00000145569 E004 18.4113052 0.0074295558 0.0022254911 0.007922517 5 14601213 14601244 32 + 1.321 0.993 -1.174
ENSG00000145569 E005 28.2853581 0.0007503575 0.0033431380 0.011271132 5 14601351 14601442 92 + 1.482 1.258 -0.778
ENSG00000145569 E006 36.7211105 0.0006085227 0.0103775436 0.029690000 5 14602183 14602332 150 + 1.580 1.412 -0.575
ENSG00000145569 E007 32.7326156 0.0007905292 0.7297396461 0.821866505 5 14607330 14607458 129 + 1.482 1.504 0.075
ENSG00000145569 E008 51.7550157 0.0007530082 0.2293840673 0.361706343 5 14608748 14609017 270 + 1.667 1.728 0.206
ENSG00000145569 E009 40.0730777 0.0050529749 0.3041148867 0.446126380 5 14610141 14610337 197 + 1.560 1.630 0.241
ENSG00000145569 E010 27.4581783 0.0008209009 0.2526781862 0.389072010 5 14610338 14610441 104 + 1.394 1.473 0.271
ENSG00000145569 E011 36.4251293 0.0008672498 0.4502701105 0.591390005 5 14610442 14610641 200 + 1.521 1.567 0.155
ENSG00000145569 E012 50.6344830 0.0005527796 0.0060397262 0.018714863 5 14610642 14611575 934 + 1.630 1.767 0.464
ENSG00000145569 E013 57.3694896 0.0076465331 0.6622722688 0.770606302 5 14611576 14614530 2955 + 1.722 1.751 0.097
ENSG00000145569 E014 16.2918673 0.0012577230 0.0107361278 0.030536238 5 14614531 14615209 679 + 1.135 1.352 0.765
ENSG00000145569 E015 7.3532223 0.0024274629 0.0304048183 0.072754086 5 14615210 14615426 217 + 0.804 1.060 0.965
ENSG00000145569 E016 3.5480939 0.0046579402 0.0712577341 0.145420861 5 14615427 14615786 360 + 0.543 0.814 1.145
ENSG00000145569 E017 0.6633060 0.0251623379 1.0000000000 1.000000000 5 14615787 14616180 394 + 0.197 0.191 -0.057