ENSG00000145555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000510401 ENSG00000145555 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO10 protein_coding processed_transcript 5.581996 5.0369 5.965966 0.449268 0.2337983 0.2437746 0.6755467 0.000000 1.0682610 0.0000000 0.38074570 6.7525627 0.1084542 0.0000000 0.1751333 0.1751333 1.003963e-06 2.555761e-35 FALSE FALSE
ENST00000513610 ENSG00000145555 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO10 protein_coding protein_coding 5.581996 5.0369 5.965966 0.449268 0.2337983 0.2437746 2.1294107 2.769600 1.4621149 0.1697133 0.16713457 -0.9169871 0.3975333 0.5530667 0.2446667 -0.3084000 2.016116e-07 2.555761e-35 FALSE TRUE
ENST00000515803 ENSG00000145555 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO10 protein_coding protein_coding 5.581996 5.0369 5.965966 0.449268 0.2337983 0.2437746 1.2833920 2.194318 0.2954139 0.2810695 0.21067269 -2.8514949 0.2409542 0.4324667 0.0514000 -0.3810667 1.642722e-02 2.555761e-35 FALSE TRUE
MSTRG.25975.4 ENSG00000145555 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO10 protein_coding   5.581996 5.0369 5.965966 0.449268 0.2337983 0.2437746 1.3954677 0.000000 2.8629343 0.0000000 0.02417371 8.1663812 0.2356125 0.0000000 0.4814000 0.4814000 2.555761e-35 2.555761e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145555 E001 0.000000       5 16661907 16661913 7 -      
ENSG00000145555 E002 285.292274 0.0073232468 6.943479e-14 2.017819e-12 5 16661914 16666379 4466 - 2.217 2.580 1.209
ENSG00000145555 E003 65.935352 0.0143167309 2.728358e-05 1.639273e-04 5 16666380 16666444 65 - 1.599 1.946 1.174
ENSG00000145555 E004 70.711748 0.0062825772 2.007339e-05 1.244508e-04 5 16666445 16666561 117 - 1.675 1.956 0.947
ENSG00000145555 E005 86.598066 0.0070373464 4.457041e-06 3.209812e-05 5 16666562 16666793 232 - 1.753 2.047 0.990
ENSG00000145555 E006 72.604813 0.0007966383 3.353892e-06 2.484981e-05 5 16668277 16668468 192 - 1.716 1.955 0.807
ENSG00000145555 E007 125.045157 0.0003809635 3.533882e-04 1.593325e-03 5 16670526 16670978 453 - 2.006 2.157 0.508
ENSG00000145555 E008 49.440422 0.0066949970 5.957554e-01 7.178004e-01 5 16671422 16671542 121 - 1.657 1.727 0.238
ENSG00000145555 E009 55.215758 0.0055711714 2.909561e-02 7.018802e-02 5 16672689 16672825 137 - 1.644 1.810 0.563
ENSG00000145555 E010 63.544925 0.0004682371 3.775871e-02 8.688433e-02 5 16673682 16673889 208 - 1.724 1.854 0.438
ENSG00000145555 E011 81.620935 0.0003609067 6.757667e-01 7.809314e-01 5 16674853 16675150 298 - 1.900 1.920 0.068
ENSG00000145555 E012 45.375204 0.0005791579 2.065648e-01 3.344194e-01 5 16676031 16676154 124 - 1.672 1.642 -0.101
ENSG00000145555 E013 43.314281 0.0005658834 7.909599e-01 8.663099e-01 5 16679947 16680104 158 - 1.624 1.646 0.074
ENSG00000145555 E014 42.156436 0.0074034763 5.188160e-01 6.529791e-01 5 16681309 16681503 195 - 1.581 1.663 0.281
ENSG00000145555 E015 43.790349 0.0139559582 8.201119e-01 8.864885e-01 5 16681871 16682013 143 - 1.631 1.656 0.086
ENSG00000145555 E016 31.045502 0.0063663327 6.316742e-01 7.466420e-01 5 16683880 16683935 56 - 1.460 1.532 0.247
ENSG00000145555 E017 34.379732 0.0012736817 3.957344e-01 5.395282e-01 5 16685738 16685831 94 - 1.493 1.581 0.301
ENSG00000145555 E018 38.780113 0.0006715134 1.120787e-01 2.085876e-01 5 16689824 16689919 96 - 1.516 1.642 0.433
ENSG00000145555 E019 55.445607 0.0095600674 4.971154e-01 6.336639e-01 5 16694371 16694614 244 - 1.699 1.779 0.272
ENSG00000145555 E020 36.894706 0.0053086940 8.364038e-01 8.976761e-01 5 16699450 16699573 124 - 1.557 1.580 0.076
ENSG00000145555 E021 105.032787 0.0003199199 1.359447e-01 2.424087e-01 5 16700963 16701838 876 - 2.026 2.012 -0.049
ENSG00000145555 E022 16.836886 0.0010934702 3.184547e-02 7.555547e-02 5 16702543 16702588 46 - 1.319 1.178 -0.497
ENSG00000145555 E023 17.960127 0.0015428183 6.861206e-04 2.848703e-03 5 16702925 16702976 52 - 1.389 1.150 -0.841
ENSG00000145555 E024 15.511061 0.0013958400 2.235962e-04 1.064607e-03 5 16702977 16702998 22 - 1.346 1.063 -1.005
ENSG00000145555 E025 13.142983 0.0016222696 6.756660e-03 2.059149e-02 5 16702999 16702999 1 - 1.253 1.038 -0.768
ENSG00000145555 E026 31.212238 0.0006315532 3.177996e-05 1.879563e-04 5 16703000 16703158 159 - 1.613 1.392 -0.759
ENSG00000145555 E027 29.279364 0.0007556915 4.993892e-02 1.090605e-01 5 16704579 16704685 107 - 1.520 1.430 -0.309
ENSG00000145555 E028 0.000000       5 16710672 16710703 32 -      
ENSG00000145555 E029 0.147249 0.0431905043 4.381581e-01   5 16710704 16710907 204 - 0.124 0.000 -8.986
ENSG00000145555 E030 26.504550 0.0034315178 1.784024e-01 2.991405e-01 5 16710908 16711014 107 - 1.460 1.399 -0.208
ENSG00000145555 E031 11.550155 0.0347578492 7.175229e-01 8.128819e-01 5 16711015 16711022 8 - 1.089 1.082 -0.024
ENSG00000145555 E032 1.066342 0.3815697054 9.703035e-01 9.854139e-01 5 16711080 16711120 41 - 0.299 0.302 0.016
ENSG00000145555 E033 17.617155 0.0011864256 7.564487e-01 8.415266e-01 5 16711121 16711159 39 - 1.253 1.262 0.034
ENSG00000145555 E034 25.975742 0.0147152291 4.439342e-02 9.909510e-02 5 16711160 16711245 86 - 1.494 1.355 -0.477
ENSG00000145555 E035 0.000000       5 16713330 16713468 139 -      
ENSG00000145555 E036 0.000000       5 16738136 16738398 263 -      
ENSG00000145555 E037 0.000000       5 16738399 16738414 16 -      
ENSG00000145555 E038 0.000000       5 16741804 16742228 425 -      
ENSG00000145555 E039 26.117973 0.0132404942 4.019859e-03 1.319753e-02 5 16754828 16754908 81 - 1.529 1.316 -0.733
ENSG00000145555 E040 29.473650 0.0060972408 2.620723e-03 9.129305e-03 5 16758118 16758226 109 - 1.565 1.383 -0.626
ENSG00000145555 E041 27.087305 0.0008613510 6.270008e-04 2.632086e-03 5 16761464 16761546 83 - 1.541 1.351 -0.656
ENSG00000145555 E042 25.948409 0.0008945672 1.631336e-03 6.061383e-03 5 16762045 16762113 69 - 1.516 1.338 -0.612
ENSG00000145555 E043 30.398231 0.0007103439 1.858767e-03 6.785189e-03 5 16762545 16762637 93 - 1.573 1.414 -0.545
ENSG00000145555 E044 30.024649 0.0025789895 9.726582e-07 8.089344e-06 5 16763481 16763547 67 - 1.624 1.332 -1.002
ENSG00000145555 E045 25.680630 0.0069015055 1.030731e-08 1.267239e-07 5 16763655 16763755 101 - 1.606 1.188 -1.452
ENSG00000145555 E046 31.031808 0.0006855455 3.090526e-06 2.305355e-05 5 16764250 16764396 147 - 1.624 1.369 -0.874
ENSG00000145555 E047 28.171082 0.0012330591 4.477716e-05 2.552553e-04 5 16766080 16766198 119 - 1.577 1.345 -0.800
ENSG00000145555 E048 26.421000 0.0021819316 2.153882e-02 5.472507e-02 5 16769074 16769203 130 - 1.498 1.375 -0.423
ENSG00000145555 E049 21.377440 0.0010044132 1.052582e-02 3.003812e-02 5 16779545 16779648 104 - 1.423 1.269 -0.535
ENSG00000145555 E050 19.339855 0.0163071985 1.040229e-02 2.975290e-02 5 16780524 16780608 85 - 1.406 1.191 -0.754
ENSG00000145555 E051 9.659610 0.0022830816 2.686629e-03 9.334002e-03 5 16780728 16780733 6 - 1.154 0.869 -1.049
ENSG00000145555 E052 9.514438 0.0020278703 3.762652e-03 1.247634e-02 5 16780734 16780741 8 - 1.143 0.869 -1.012
ENSG00000145555 E053 22.714608 0.0008736746 2.310331e-09 3.202497e-08 5 16781705 16781829 125 - 1.545 1.140 -1.414
ENSG00000145555 E054 22.965679 0.0008139903 9.421622e-10 1.403773e-08 5 16783335 16783469 135 - 1.553 1.140 -1.442
ENSG00000145555 E055 24.205858 0.0009910428 6.663001e-07 5.748374e-06 5 16794646 16794833 188 - 1.545 1.230 -1.092
ENSG00000145555 E056 4.057891 0.0089608355 4.559544e-01 5.964302e-01 5 16814517 16815463 947 - 0.600 0.740 0.592
ENSG00000145555 E057 19.107270 0.0113287149 1.025696e-02 2.939846e-02 5 16818009 16818167 159 - 1.395 1.198 -0.689
ENSG00000145555 E058 17.120882 0.0011514822 5.176306e-05 2.905157e-04 5 16877609 16877707 99 - 1.395 1.097 -1.049
ENSG00000145555 E059 0.000000       5 16916055 16916527 473 -      
ENSG00000145555 E060 30.963064 0.0202299741 1.140417e-05 7.480127e-05 5 16935788 16936288 501 - 1.666 1.301 -1.255