ENSG00000145506

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274150 ENSG00000145506 HEK293_OSMI2_2hA HEK293_TMG_2hB NKD2 protein_coding protein_coding 11.02123 16.50002 7.892623 0.8824773 0.3683848 -1.062939 0.5870743 0.5930653 0.141837 0.1419908 0.04798143 -1.9897912 0.0527375 0.03613333 0.01753333 -0.01860000 3.823860e-01 1.819761e-10 FALSE TRUE
ENST00000296849 ENSG00000145506 HEK293_OSMI2_2hA HEK293_TMG_2hB NKD2 protein_coding protein_coding 11.02123 16.50002 7.892623 0.8824773 0.3683848 -1.062939 4.8091372 7.0179550 3.618839 0.8498743 0.08028461 -0.9535971 0.4305292 0.42230000 0.46043333 0.03813333 7.477048e-01 1.819761e-10 FALSE TRUE
ENST00000513296 ENSG00000145506 HEK293_OSMI2_2hA HEK293_TMG_2hB NKD2 protein_coding retained_intron 11.02123 16.50002 7.892623 0.8824773 0.3683848 -1.062939 1.4772670 1.7772301 1.022900 0.1945710 0.13950822 -0.7910247 0.1418583 0.10773333 0.12863333 0.02090000 6.703553e-01 1.819761e-10 FALSE TRUE
ENST00000519933 ENSG00000145506 HEK293_OSMI2_2hA HEK293_TMG_2hB NKD2 protein_coding retained_intron 11.02123 16.50002 7.892623 0.8824773 0.3683848 -1.062939 3.2402922 4.0272140 2.850336 0.1776251 0.36446832 -0.4971753 0.3095500 0.24433333 0.35940000 0.11506667 4.735168e-02 1.819761e-10 FALSE FALSE
ENST00000523688 ENSG00000145506 HEK293_OSMI2_2hA HEK293_TMG_2hB NKD2 protein_coding retained_intron 11.02123 16.50002 7.892623 0.8824773 0.3683848 -1.062939 0.3868230 1.7130363 0.000000 0.2557736 0.00000000 -7.4288093 0.0258750 0.10606667 0.00000000 -0.10606667 1.819761e-10 1.819761e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145506 E001 22.520576 0.0762213514 1.003096e-01 1.909540e-01 5 1008802 1008961 160 + 1.461 1.236 -0.782
ENSG00000145506 E002 28.084222 0.0374277880 7.725569e-03 2.309041e-02 5 1008962 1009082 121 + 1.599 1.301 -1.028
ENSG00000145506 E003 17.245582 0.0541804436 2.407058e-01 3.750082e-01 5 1009179 1009214 36 + 1.315 1.148 -0.590
ENSG00000145506 E004 28.608098 0.0007326328 8.393599e-02 1.657054e-01 5 1009481 1009560 80 + 1.498 1.368 -0.448
ENSG00000145506 E005 35.964737 0.0006225835 1.195753e-02 3.342854e-02 5 1032152 1032212 61 + 1.616 1.451 -0.563
ENSG00000145506 E006 65.277626 0.0004461350 6.161221e-02 1.293353e-01 5 1033372 1033499 128 + 1.827 1.730 -0.328
ENSG00000145506 E007 19.236584 0.0009916789 3.635016e-03 1.211205e-02 5 1034136 1034234 99 + 1.412 1.168 -0.852
ENSG00000145506 E008 90.256779 0.0026863194 9.846786e-01 9.944950e-01 5 1034235 1034330 96 + 1.903 1.894 -0.033
ENSG00000145506 E009 122.200458 0.0013027365 4.950142e-01 6.318954e-01 5 1034756 1034903 148 + 2.014 2.029 0.051
ENSG00000145506 E010 96.804488 0.0006738568 6.493430e-01 7.606357e-01 5 1035389 1035473 85 + 1.917 1.925 0.025
ENSG00000145506 E011 14.965776 0.0307583958 2.340379e-01 3.671866e-01 5 1035805 1036109 305 + 1.257 1.092 -0.586
ENSG00000145506 E012 33.260733 0.0013951126 6.301297e-01 7.453544e-01 5 1036110 1036256 147 + 1.498 1.455 -0.149
ENSG00000145506 E013 104.676072 0.0003175604 5.074299e-01 6.429570e-01 5 1036257 1036384 128 + 1.944 1.957 0.046
ENSG00000145506 E014 6.530878 0.0032763183 9.982055e-01 1.000000e+00 5 1037520 1037698 179 + 0.825 0.815 -0.038
ENSG00000145506 E015 279.251730 0.0002577257 1.409364e-10 2.425535e-09 5 1037805 1038943 1139 + 2.277 2.408 0.438