ENSG00000145495

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274140 ENSG00000145495 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF6 protein_coding protein_coding 42.20287 25.1139 50.16285 2.317887 0.4285307 0.9978461 5.986937 4.5369124 6.473150 0.5919080 0.5069643 0.5118078 0.14423333 0.18206667 0.1292333 -0.052833333 2.614714e-01 2.307789e-07 FALSE TRUE
ENST00000449913 ENSG00000145495 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF6 protein_coding protein_coding 42.20287 25.1139 50.16285 2.317887 0.4285307 0.9978461 9.276945 3.1231679 10.448310 1.0259553 0.4454752 1.7389558 0.21129583 0.12173333 0.2083000 0.086566667 1.865533e-01 2.307789e-07 FALSE TRUE
ENST00000510792 ENSG00000145495 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF6 protein_coding protein_coding 42.20287 25.1139 50.16285 2.317887 0.4285307 0.9978461 1.912263 4.1824438 0.000000 2.1551490 0.0000000 -8.7116476 0.06821250 0.16470000 0.0000000 -0.164700000 1.616586e-06 2.307789e-07 FALSE TRUE
ENST00000511802 ENSG00000145495 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF6 protein_coding retained_intron 42.20287 25.1139 50.16285 2.317887 0.4285307 0.9978461 3.949854 0.5908755 6.254931 0.1216297 0.1688831 3.3821607 0.08039167 0.02493333 0.1247667 0.099833333 2.307789e-07 2.307789e-07 FALSE TRUE
MSTRG.25940.9 ENSG00000145495 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF6 protein_coding   42.20287 25.1139 50.16285 2.317887 0.4285307 0.9978461 19.688377 12.1814165 24.554568 1.9233256 0.4255456 1.0107131 0.46628750 0.48800000 0.4894333 0.001433333 1.000000e+00 2.307789e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145495 E001 1.6220787 0.1299008864 4.820062e-01 6.201670e-01 5 10353695 10353702 8 + 0.346 0.502 0.837
ENSG00000145495 E002 6.4249569 0.0066626145 1.223682e-01 2.233232e-01 5 10353703 10353710 8 + 0.931 0.729 -0.791
ENSG00000145495 E003 11.0449067 0.0112220127 2.408068e-01 3.751193e-01 5 10353711 10353714 4 + 1.119 0.988 -0.480
ENSG00000145495 E004 12.9344019 0.0026836589 2.970052e-01 4.382998e-01 5 10353715 10353715 1 + 1.172 1.075 -0.348
ENSG00000145495 E005 133.5968980 0.0090147051 2.613104e-03 9.104774e-03 5 10353716 10353898 183 + 2.182 2.014 -0.561
ENSG00000145495 E006 109.6760137 0.0097229884 4.722475e-05 2.677016e-04 5 10353899 10353917 19 + 2.119 1.871 -0.831
ENSG00000145495 E007 0.1451727 0.0429707424 8.623428e-01   5 10353968 10353996 29 + 0.095 0.000 -10.361
ENSG00000145495 E008 0.0000000       5 10354050 10354074 25 +      
ENSG00000145495 E009 0.0000000       5 10354639 10354671 33 +      
ENSG00000145495 E010 181.9938985 0.0048525577 2.682911e-06 2.030235e-05 5 10377798 10377894 97 + 2.326 2.120 -0.689
ENSG00000145495 E011 171.6858040 0.0056458081 1.491048e-06 1.193285e-05 5 10378759 10378832 74 + 2.307 2.082 -0.753
ENSG00000145495 E012 228.6076656 0.0072892048 3.885950e-03 1.282435e-02 5 10381800 10381943 144 + 2.404 2.266 -0.460
ENSG00000145495 E013 0.4439371 0.0215504218 2.178276e-01 3.477939e-01 5 10386925 10386993 69 + 0.238 0.000 -11.946
ENSG00000145495 E014 163.7873018 0.0014833468 3.631139e-02 8.417355e-02 5 10386994 10387066 73 + 2.236 2.169 -0.224
ENSG00000145495 E015 232.0265970 0.0075090465 5.949902e-02 1.257658e-01 5 10390332 10390500 169 + 2.394 2.303 -0.302
ENSG00000145495 E016 283.5927712 0.0023855726 1.092242e-02 3.097589e-02 5 10391542 10391731 190 + 2.477 2.398 -0.263
ENSG00000145495 E017 198.1461388 0.0018460433 1.110776e-01 2.071214e-01 5 10394082 10394143 62 + 2.312 2.263 -0.162
ENSG00000145495 E018 157.3855035 0.0002277576 2.139457e-02 5.442206e-02 5 10394753 10394785 33 + 2.217 2.155 -0.207
ENSG00000145495 E019 177.7619416 0.0005378041 1.306370e-03 4.997836e-03 5 10397293 10397344 52 + 2.280 2.191 -0.298
ENSG00000145495 E020 201.8655868 0.0015072555 8.259643e-04 3.352181e-03 5 10400784 10400842 59 + 2.339 2.235 -0.345
ENSG00000145495 E021 17.5451542 0.0036842785 6.216781e-09 7.973938e-08 5 10400843 10400932 90 + 1.416 0.824 -2.145
ENSG00000145495 E022 56.4622588 0.0062045102 2.655826e-14 8.202450e-13 5 10400933 10401486 554 + 1.894 1.366 -1.798
ENSG00000145495 E023 39.8358305 0.0450077516 1.372528e-04 6.914172e-04 5 10401487 10401856 370 + 1.735 1.263 -1.620
ENSG00000145495 E024 18.4328184 0.0017578353 2.249509e-04 1.070115e-03 5 10401857 10402058 202 + 1.382 1.059 -1.144
ENSG00000145495 E025 250.7967143 0.0023194415 7.478538e-04 3.071092e-03 5 10402059 10402139 81 + 2.434 2.325 -0.364
ENSG00000145495 E026 216.8145779 0.0034016607 2.368619e-01 3.705462e-01 5 10402384 10402452 69 + 2.348 2.305 -0.141
ENSG00000145495 E027 203.6276135 0.0021493142 6.571683e-01 7.665884e-01 5 10402533 10402607 75 + 2.297 2.314 0.057
ENSG00000145495 E028 250.5728244 0.0003265334 1.781238e-01 2.987872e-01 5 10403407 10403541 135 + 2.380 2.418 0.127
ENSG00000145495 E029 261.5940401 0.0008746776 2.068250e-01 3.347462e-01 5 10405558 10405677 120 + 2.399 2.437 0.128
ENSG00000145495 E030 234.0412905 0.0001701813 1.140299e-01 2.113968e-01 5 10407102 10407202 101 + 2.349 2.393 0.147
ENSG00000145495 E031 118.8668335 0.0015507767 1.523033e-01 2.648242e-01 5 10410139 10410152 14 + 2.050 2.110 0.203
ENSG00000145495 E032 237.2883670 0.0001824291 7.978842e-02 1.592331e-01 5 10410153 10410276 124 + 2.351 2.399 0.159
ENSG00000145495 E033 330.2916764 0.0001679663 2.941106e-04 1.355909e-03 5 10411333 10411537 205 + 2.482 2.561 0.263
ENSG00000145495 E034 3.1911176 0.0050651886 9.000318e-02 1.751426e-01 5 10413274 10413450 177 + 0.710 0.438 -1.248
ENSG00000145495 E035 233.9055397 0.0001757558 8.348391e-03 2.466129e-02 5 10414433 10414502 70 + 2.337 2.406 0.230
ENSG00000145495 E036 2.9140093 0.0060884160 3.663677e-01 5.107080e-01 5 10415473 10415487 15 + 0.644 0.502 -0.645
ENSG00000145495 E037 332.4243670 0.0016915241 4.247227e-02 9.557586e-02 5 10415488 10415598 111 + 2.492 2.553 0.201
ENSG00000145495 E038 276.7156062 0.0008257541 8.333036e-03 2.462591e-02 5 10415599 10415669 71 + 2.408 2.480 0.239
ENSG00000145495 E039 338.4909664 0.0039482147 3.866432e-02 8.856157e-02 5 10417270 10417404 135 + 2.492 2.570 0.260
ENSG00000145495 E040 2.4001544 0.0086701471 9.253798e-01 9.570235e-01 5 10417405 10417410 6 + 0.535 0.557 0.100
ENSG00000145495 E041 0.7363589 0.0155484420 7.036055e-02 1.439528e-01 5 10417411 10417451 41 + 0.346 0.000 -12.683
ENSG00000145495 E042 0.2944980 0.3456858938 5.137034e-01   5 10421931 10422036 106 + 0.172 0.000 -11.361
ENSG00000145495 E043 315.9916670 0.0020169200 9.581002e-03 2.773566e-02 5 10423735 10423824 90 + 2.461 2.544 0.275
ENSG00000145495 E044 0.2966881 0.0270302016 4.132917e-01   5 10423825 10423835 11 + 0.172 0.000 -11.361
ENSG00000145495 E045 362.3099520 0.0011952371 9.908507e-06 6.592751e-05 5 10426390 10426522 133 + 2.506 2.622 0.385
ENSG00000145495 E046 316.5097028 0.0010768551 1.284295e-10 2.225426e-09 5 10429893 10430028 136 + 2.423 2.591 0.559
ENSG00000145495 E047 411.1958610 0.0036015388 3.245010e-05 1.914357e-04 5 10433594 10433928 335 + 2.546 2.688 0.472
ENSG00000145495 E048 138.7299185 0.0002541239 1.134271e-13 3.196731e-12 5 10433929 10434207 279 + 2.221 1.984 -0.795
ENSG00000145495 E049 706.6942233 0.0099362139 6.381417e-02 1.330406e-01 5 10434208 10436794 2587 + 2.875 2.787 -0.293
ENSG00000145495 E050 513.8945943 0.0193042365 6.090667e-04 2.566126e-03 5 10436795 10440388 3594 + 2.592 2.830 0.793