ENSG00000145439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306193 ENSG00000145439 HEK293_OSMI2_2hA HEK293_TMG_2hB CBR4 protein_coding protein_coding 14.26619 11.89768 18.92337 0.5008127 0.7277672 0.6690396 4.336537 2.2278652 7.020705 0.1080841 0.4407103 1.6515463 0.2795667 0.18753333 0.3729667 0.18543333 0.0001983513 0.0001983513 FALSE TRUE
MSTRG.25713.12 ENSG00000145439 HEK293_OSMI2_2hA HEK293_TMG_2hB CBR4 protein_coding   14.26619 11.89768 18.92337 0.5008127 0.7277672 0.6690396 3.950125 3.9361289 5.002828 0.7163621 0.6451963 0.3451867 0.2912208 0.32746667 0.2625333 -0.06493333 0.6332059103 0.0001983513 FALSE TRUE
MSTRG.25713.13 ENSG00000145439 HEK293_OSMI2_2hA HEK293_TMG_2hB CBR4 protein_coding   14.26619 11.89768 18.92337 0.5008127 0.7277672 0.6690396 1.465935 0.8267517 2.735104 0.4416434 0.2707816 1.7139890 0.1028167 0.07273333 0.1455667 0.07283333 0.6210024968 0.0001983513   TRUE
MSTRG.25713.14 ENSG00000145439 HEK293_OSMI2_2hA HEK293_TMG_2hB CBR4 protein_coding   14.26619 11.89768 18.92337 0.5008127 0.7277672 0.6690396 2.767217 3.5039165 2.168703 0.2083155 0.4924194 -0.6896106 0.1998083 0.29433333 0.1138667 -0.18046667 0.0002600553 0.0001983513 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145439 E001 0.2966881 0.0269380079 4.167154e-01   4 168863551 168863621 71 - 0.174 0.000 -10.178
ENSG00000145439 E002 0.1472490 0.0439351023 8.640102e-01   4 168863770 168863792 23 - 0.096 0.000 -11.105
ENSG00000145439 E003 0.4439371 0.0215747150 2.206806e-01 3.512272e-01 4 168863793 168863879 87 - 0.241 0.000 -12.724
ENSG00000145439 E004 0.1515154 0.0432077452 8.641331e-01   4 168863880 168863890 11 - 0.096 0.000 -11.109
ENSG00000145439 E005 0.9684132 0.0146880090 3.082280e-01 4.504923e-01 4 168863891 168863973 83 - 0.349 0.155 -1.526
ENSG00000145439 E006 1.2586448 0.0273298061 1.483572e-01 2.594448e-01 4 168864372 168864521 150 - 0.436 0.155 -2.010
ENSG00000145439 E007 1.3327393 0.1027472986 4.652236e-01 6.049400e-01 4 168864522 168864586 65 - 0.299 0.434 0.798
ENSG00000145439 E008 1.2929984 0.0187195571 4.243639e-01 5.673369e-01 4 168894570 168894601 32 - 0.298 0.434 0.794
ENSG00000145439 E009 7.8112186 0.0021495019 1.193703e-04 6.109841e-04 4 168894602 168894765 164 - 0.716 1.142 1.614
ENSG00000145439 E010 1.7056999 0.1348916959 4.435509e-01 5.851291e-01 4 168928573 168928677 105 - 0.350 0.501 0.809
ENSG00000145439 E011 2.7323275 0.0056346754 1.563742e-01 2.703050e-01 4 168987590 168987627 38 - 0.474 0.686 0.964
ENSG00000145439 E012 19.5357032 0.0041829518 1.209474e-01 2.212994e-01 4 168987628 168987755 128 - 1.262 1.374 0.391
ENSG00000145439 E013 162.1840089 0.0006063227 3.167446e-05 1.873734e-04 4 168987756 168989004 1249 - 2.259 2.125 -0.447
ENSG00000145439 E014 110.1419249 0.0109335498 2.359491e-07 2.230197e-06 4 168989005 168989996 992 - 2.144 1.813 -1.112
ENSG00000145439 E015 15.7202780 0.0061429254 2.570752e-01 3.941162e-01 4 168989997 168990021 25 - 1.262 1.141 -0.429
ENSG00000145439 E016 18.2634161 0.0010436478 1.261033e-01 2.287301e-01 4 168990022 168990031 10 - 1.333 1.192 -0.493
ENSG00000145439 E017 153.6503618 0.0002626296 2.074857e-04 9.959852e-04 4 168990032 168990328 297 - 2.146 2.233 0.290
ENSG00000145439 E018 26.8826259 0.0007585308 2.606706e-02 6.408334e-02 4 168998202 168998285 84 - 1.375 1.509 0.461
ENSG00000145439 E019 3.7259258 0.0093913936 1.233164e-02 3.433002e-02 4 169001169 169001574 406 - 0.792 0.359 -2.010
ENSG00000145439 E020 3.9472718 0.0041200048 5.403715e-03 1.702479e-02 4 169001575 169002070 496 - 0.825 0.359 -2.144
ENSG00000145439 E021 128.2441415 0.0008544286 4.460249e-04 1.951592e-03 4 169002071 169002205 135 - 2.063 2.160 0.324
ENSG00000145439 E022 6.4234051 0.0033228490 4.655505e-01 6.052259e-01 4 169005885 169005914 30 - 0.841 0.918 0.296
ENSG00000145439 E023 91.5695713 0.0003910386 3.413275e-02 8.002311e-02 4 169006755 169006801 47 - 1.932 1.994 0.210
ENSG00000145439 E024 91.0619984 0.0003789469 9.717414e-02 1.861618e-01 4 169006802 169006891 90 - 1.937 1.983 0.155
ENSG00000145439 E025 45.0937321 0.0004715404 7.323438e-01 8.238130e-01 4 169007636 169007640 5 - 1.655 1.659 0.011
ENSG00000145439 E026 86.0821817 0.0003669952 9.644749e-01 9.816152e-01 4 169007641 169007756 116 - 1.942 1.929 -0.043
ENSG00000145439 E027 4.0361280 0.0040001372 1.669846e-01 2.842703e-01 4 169008952 169008999 48 - 0.774 0.553 -0.942
ENSG00000145439 E028 2.9225421 0.0052568592 3.824968e-01 5.266901e-01 4 169009000 169009054 55 - 0.649 0.497 -0.691
ENSG00000145439 E029 1.3725078 0.0097835182 8.759154e-01 9.243101e-01 4 169009055 169009056 2 - 0.395 0.359 -0.207
ENSG00000145439 E030 2.3658244 0.0685597927 7.724514e-01 8.531315e-01 4 169009057 169009113 57 - 0.509 0.552 0.202
ENSG00000145439 E031 2.2572615 0.0064350250 5.249457e-02 1.136032e-01 4 169009361 169009392 32 - 0.625 0.269 -1.906
ENSG00000145439 E032 110.8487706 0.0075792812 5.219269e-01 6.558037e-01 4 169009948 169010275 328 - 2.038 2.055 0.057