ENSG00000145332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273963 ENSG00000145332 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL8 protein_coding protein_coding 7.137211 1.489826 11.56171 0.07124996 0.4567596 2.947735 2.988554 0.72241367 4.919867 0.22854461 0.1202959 2.750818 0.51167917 0.47820000 0.4268667 -0.05133333 9.016036e-01 3.424983e-16 FALSE TRUE
ENST00000425278 ENSG00000145332 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL8 protein_coding protein_coding 7.137211 1.489826 11.56171 0.07124996 0.4567596 2.947735 1.504611 0.07397453 2.543792 0.03714981 0.3052631 4.926545 0.18837500 0.05216667 0.2191333 0.16696667 1.134288e-03 3.424983e-16 FALSE TRUE
ENST00000498875 ENSG00000145332 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL8 protein_coding protein_coding 7.137211 1.489826 11.56171 0.07124996 0.4567596 2.947735 0.194046 0.68843722 0.000000 0.17697474 0.0000000 -6.126059 0.09481667 0.46660000 0.0000000 -0.46660000 6.758283e-11 3.424983e-16 FALSE TRUE
ENST00000512111 ENSG00000145332 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL8 protein_coding protein_coding 7.137211 1.489826 11.56171 0.07124996 0.4567596 2.947735 2.286378 0.00000000 3.876634 0.00000000 0.2281375 8.602377 0.18107500 0.00000000 0.3348000 0.33480000 3.424983e-16 3.424983e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145332 E001 3.4998188 0.0150478227 1.489154e-04 7.423512e-04 4 87160103 87160248 146 - 0.383 1.001 2.669
ENSG00000145332 E002 72.0565786 0.0053988030 3.457187e-20 2.252248e-18 4 87160249 87161042 794 - 1.594 2.124 1.786
ENSG00000145332 E003 230.6132424 0.0030225882 1.943385e-12 4.542487e-11 4 87161043 87162443 1401 - 2.178 2.438 0.869
ENSG00000145332 E004 20.0536625 0.0009114128 1.855959e-03 6.776404e-03 4 87162444 87162521 78 - 1.130 1.436 1.072
ENSG00000145332 E005 152.2407018 0.0003585249 4.232384e-01 5.663365e-01 4 87162522 87163416 895 - 2.042 2.100 0.195
ENSG00000145332 E006 74.1315056 0.0072327135 4.259395e-01 5.688091e-01 4 87163417 87163642 226 - 1.747 1.722 -0.087
ENSG00000145332 E007 28.8677658 0.0011487606 3.653808e-01 5.096923e-01 4 87163878 87163882 5 - 1.353 1.299 -0.188
ENSG00000145332 E008 67.9417816 0.0004027145 4.915713e-03 1.569560e-02 4 87163883 87164079 197 - 1.726 1.579 -0.498
ENSG00000145332 E009 49.2106480 0.0012249601 1.949284e-04 9.423148e-04 4 87170079 87170198 120 - 1.601 1.333 -0.923
ENSG00000145332 E010 37.8541219 0.0015238906 4.589491e-04 2.002361e-03 4 87170199 87170238 40 - 1.492 1.198 -1.022
ENSG00000145332 E011 71.7782825 0.0091959932 8.622824e-03 2.534432e-02 4 87170447 87170615 169 - 1.751 1.571 -0.610
ENSG00000145332 E012 70.3238142 0.0003431493 2.875576e-02 6.951424e-02 4 87176757 87176868 112 - 1.734 1.632 -0.345
ENSG00000145332 E013 65.6446638 0.0109232752 3.376890e-01 4.815809e-01 4 87178477 87178620 144 - 1.698 1.649 -0.166
ENSG00000145332 E014 61.3934132 0.0058742648 2.550273e-02 6.291680e-02 4 87183203 87183389 187 - 1.681 1.541 -0.479
ENSG00000145332 E015 66.2043885 0.0003564104 5.068649e-06 3.602272e-05 4 87185251 87185571 321 - 1.730 1.449 -0.960
ENSG00000145332 E016 50.4695403 0.0027847466 3.051869e-05 1.812721e-04 4 87185572 87185799 228 - 1.618 1.298 -1.101
ENSG00000145332 E017 71.6709082 0.0030194076 8.621235e-07 7.261224e-06 4 87195324 87195690 367 - 1.766 1.436 -1.126
ENSG00000145332 E018 0.7814233 0.1094529220 7.138985e-01 8.102634e-01 4 87218094 87218187 94 - 0.181 0.261 0.672
ENSG00000145332 E019 0.4407149 0.0215719264 3.783310e-01 5.226048e-01 4 87219524 87220034 511 - 0.100 0.260 1.671
ENSG00000145332 E020 0.4470576 0.0214745982 3.783172e-01 5.225906e-01 4 87220035 87220417 383 - 0.100 0.260 1.670
ENSG00000145332 E021 28.3270739 0.0007321798 2.012058e-04 9.689084e-04 4 87220418 87221390 973 - 1.377 1.002 -1.336
ENSG00000145332 E022 0.0000000       4 87240258 87240314 57 -