ENSG00000145331

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394876 ENSG00000145331 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT10A protein_coding protein_coding 6.115409 1.435646 11.33003 0.1856415 0.5976608 2.971639 1.7440421 0.51768837 3.2076361 0.13773377 0.7018304 2.608243 0.2541417 0.35100000 0.2803333 -0.07066667 7.146224e-01 9.773775e-05 FALSE TRUE
ENST00000394877 ENSG00000145331 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT10A protein_coding protein_coding 6.115409 1.435646 11.33003 0.1856415 0.5976608 2.971639 0.8014598 0.47092244 1.5363543 0.29690936 0.4745781 1.684995 0.1942250 0.32933333 0.1389333 -0.19040000 8.066511e-01 9.773775e-05 FALSE TRUE
ENST00000515831 ENSG00000145331 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT10A protein_coding retained_intron 6.115409 1.435646 11.33003 0.1856415 0.5976608 2.971639 0.2240086 0.00000000 0.3232702 0.00000000 0.1616401 5.058620 0.0509625 0.00000000 0.0296000 0.02960000 6.318013e-01 9.773775e-05   FALSE
MSTRG.25221.4 ENSG00000145331 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT10A protein_coding   6.115409 1.435646 11.33003 0.1856415 0.5976608 2.971639 1.3762380 0.05647855 3.1241872 0.02992221 0.5194277 5.559059 0.1989333 0.03496667 0.2729000 0.23793333 9.773775e-05 9.773775e-05 FALSE TRUE
MSTRG.25221.5 ENSG00000145331 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT10A protein_coding   6.115409 1.435646 11.33003 0.1856415 0.5976608 2.971639 1.7181694 0.34623587 2.7440458 0.19970913 0.1720088 2.950648 0.2459667 0.25313333 0.2427667 -0.01036667 9.291991e-01 9.773775e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145331 E001 0.4417591 0.0340044992 3.723873e-02 0.0859310309 4 99546709 99546710 2 - 0.051 0.430 3.758
ENSG00000145331 E002 0.4417591 0.0340044992 3.723873e-02 0.0859310309 4 99546711 99546726 16 - 0.051 0.430 3.758
ENSG00000145331 E003 132.3144951 0.0124071328 7.727846e-05 0.0004151591 4 99546727 99548769 2043 - 1.934 2.194 0.873
ENSG00000145331 E004 9.5957762 0.0018289142 2.621718e-01 0.3999232529 4 99548770 99548844 75 - 0.867 1.048 0.675
ENSG00000145331 E005 88.6811862 0.0003071130 5.488667e-03 0.0172582833 4 99548845 99549356 512 - 1.781 1.946 0.554
ENSG00000145331 E006 52.3713634 0.0009740580 9.659142e-01 0.9825575034 4 99550885 99550990 106 - 1.584 1.620 0.123
ENSG00000145331 E007 33.0855029 0.0009400142 4.809611e-02 0.1057994952 4 99553785 99553812 28 - 1.413 1.274 -0.481
ENSG00000145331 E008 29.7673493 0.0006677012 4.521225e-03 0.0146029634 4 99553813 99553830 18 - 1.380 1.137 -0.854
ENSG00000145331 E009 48.8392860 0.0004513823 1.415523e-03 0.0053586160 4 99553831 99553934 104 - 1.582 1.378 -0.702
ENSG00000145331 E010 47.0394677 0.0005401460 2.325266e-01 0.3654570211 4 99556146 99556220 75 - 1.545 1.499 -0.160
ENSG00000145331 E011 43.7490861 0.0006389599 2.125431e-01 0.3415498774 4 99557345 99557416 72 - 1.517 1.462 -0.187
ENSG00000145331 E012 0.5848434 0.0318999792 7.765887e-01 0.8561193645 4 99557417 99557530 114 - 0.176 0.001 -8.362
ENSG00000145331 E013 1.0654260 0.1494863697 9.308746e-01 0.9605079458 4 99557689 99558048 360 - 0.243 0.267 0.182
ENSG00000145331 E014 62.8929794 0.0006091236 4.164427e-02 0.0940825029 4 99558049 99558211 163 - 1.674 1.583 -0.309
ENSG00000145331 E015 64.7214893 0.0004392183 1.300391e-01 0.2342192603 4 99559154 99559350 197 - 1.682 1.629 -0.181
ENSG00000145331 E016 16.4792638 0.0012041229 1.416793e-01 0.2503354585 4 99559351 99559361 11 - 1.122 0.977 -0.529
ENSG00000145331 E017 2.7636278 0.0784343177 7.975131e-01 0.8708052912 4 99563368 99563557 190 - 0.477 0.432 -0.227
ENSG00000145331 E018 19.2667404 0.0009954496 3.433909e-02 0.0804116165 4 99563558 99563912 355 - 1.194 0.977 -0.785
ENSG00000145331 E019 19.8073600 0.0009913256 2.677472e-01 0.4060869207 4 99563913 99564039 127 - 1.194 1.110 -0.300