ENSG00000145287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311507 ENSG00000145287 HEK293_OSMI2_2hA HEK293_TMG_2hB PLAC8 protein_coding protein_coding 1.166954 1.736097 1.322079 0.1910995 0.1710856 -0.3904539 0.07355178 0.06421449 0.1384570 0.01156651 0.04899948 1.000273 0.07487917 0.037233333 0.09793333 0.0607000 0.25197744 0.02725843 FALSE FALSE
ENST00000411416 ENSG00000145287 HEK293_OSMI2_2hA HEK293_TMG_2hB PLAC8 protein_coding protein_coding 1.166954 1.736097 1.322079 0.1910995 0.1710856 -0.3904539 0.93835796 1.65582613 0.6504474 0.17188721 0.21578611 -1.334722 0.78323333 0.955100000 0.53780000 -0.4173000 0.04600221 0.02725843 FALSE TRUE
ENST00000505406 ENSG00000145287 HEK293_OSMI2_2hA HEK293_TMG_2hB PLAC8 protein_coding protein_coding 1.166954 1.736097 1.322079 0.1910995 0.1710856 -0.3904539 0.10400174 0.01605628 0.1747992 0.01605628 0.06606520 2.826256 0.10420000 0.007666667 0.13653333 0.1288667 0.02725843 0.02725843 TRUE FALSE
ENST00000509973 ENSG00000145287 HEK293_OSMI2_2hA HEK293_TMG_2hB PLAC8 protein_coding protein_coding 1.166954 1.736097 1.322079 0.1910995 0.1710856 -0.3904539 0.04398157 0.00000000 0.3518525 0.00000000 0.35185255 5.177330 0.02788333 0.000000000 0.22306667 0.2230667 0.80116733 0.02725843 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145287 E001 0.6611159 0.019725825 0.13782525 0.24505702 4 83090048 83090687 640 - 0.357 0.097 -2.357
ENSG00000145287 E002 0.7374030 0.015861011 0.05589252 0.11950287 4 83090688 83090792 105 - 0.432 0.096 -2.776
ENSG00000145287 E003 1.1929934 0.299129286 0.10139061 0.19258277 4 83090793 83090805 13 - 0.552 0.171 -2.407
ENSG00000145287 E004 9.1409682 0.001978778 0.06580952 0.13638858 4 83090806 83090971 166 - 1.111 0.914 -0.725
ENSG00000145287 E005 0.1451727 0.043765932 0.30939106   4 83092861 83094677 1817 - 0.154 0.000 -11.142
ENSG00000145287 E006 12.8095999 0.001724613 0.78852846 0.86461802 4 83094678 83094791 114 - 1.152 1.112 -0.145
ENSG00000145287 E007 14.9225243 0.001458633 0.27294691 0.41192266 4 83104896 83105020 125 - 1.139 1.208 0.248
ENSG00000145287 E008 12.1969388 0.002047712 0.01482170 0.04009146 4 83107804 83107950 147 - 0.938 1.152 0.784
ENSG00000145287 E009 7.2826996 0.002961504 0.01663474 0.04413171 4 83109728 83109843 116 - 0.684 0.964 1.100
ENSG00000145287 E010 0.7321030 0.099278997 0.58141855 0.70595021 4 83114666 83114715 50 - 0.154 0.244 0.824
ENSG00000145287 E011 0.0000000       4 83114716 83114729 14 -      
ENSG00000145287 E012 0.0000000       4 83114730 83114736 7 -      
ENSG00000145287 E013 0.4439371 0.022211698 0.03203821 0.07592812 4 83115265 83115432 168 - 0.357 0.000 -12.494
ENSG00000145287 E014 0.1472490 0.044391054 0.30877175   4 83117884 83117971 88 - 0.154 0.000 -11.142
ENSG00000145287 E015 1.4821784 0.010242403 0.28480221 0.42506617 4 83134535 83134634 100 - 0.495 0.300 -1.096
ENSG00000145287 E016 1.5101918 0.009980295 0.15772787 0.27209411 4 83136959 83137075 117 - 0.551 0.300 -1.362