ENSG00000145214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273814 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding protein_coding 10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 5.960288 8.2650642 3.8228732 0.4561734 0.19288928 -1.1103442 0.55150417 0.70233333 0.51366667 -0.188666667 2.422984e-01 1.620953e-05 FALSE TRUE
ENST00000502309 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding processed_transcript 10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 0.621947 0.7881975 0.5886957 0.4034094 0.13614201 -0.4149228 0.06331667 0.05726667 0.08003333 0.022766667 7.815694e-01 1.620953e-05 FALSE TRUE
ENST00000509465 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding protein_coding 10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 1.000391 0.7844335 0.4993106 0.5261893 0.49931057 -0.6413808 0.08685833 0.05456667 0.06070000 0.006133333 7.021074e-01 1.620953e-05 FALSE TRUE
ENST00000515182 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding protein_coding 10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 0.612077 0.6784542 0.6298873 0.3563471 0.20453853 -0.1055427 0.06013333 0.04896667 0.08296667 0.034000000 7.207755e-01 1.620953e-05 FALSE TRUE
MSTRG.24430.3 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding   10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 1.066488 0.5795490 0.4397862 0.1282594 0.09324134 -0.3903722 0.09111667 0.05360000 0.05886667 0.005266667 9.145779e-01 1.620953e-05 FALSE TRUE
MSTRG.24430.9 ENSG00000145214 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKQ protein_coding   10.79393 12.13061 7.518237 1.81799 0.3858258 -0.6894575 1.070733 0.5629811 1.1200672 0.1363471 0.10995744 0.9798491 0.10377083 0.04600000 0.14880000 0.102800000 1.620953e-05 1.620953e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145214 E001 2.978736 0.0589129538 4.844335e-01 6.224403e-01 4 958887 958887 1 - 0.448 0.588 0.673
ENSG00000145214 E002 184.724804 0.0009329053 9.409192e-07 7.851576e-06 4 958888 959429 542 - 2.113 2.268 0.521
ENSG00000145214 E003 314.304250 0.0026959832 4.065120e-04 1.799735e-03 4 959430 960167 738 - 2.377 2.490 0.375
ENSG00000145214 E004 180.443390 0.0002466355 4.533736e-02 1.008102e-01 4 960168 960614 447 - 2.172 2.230 0.196
ENSG00000145214 E005 61.012757 0.0004436186 3.541166e-02 8.244400e-02 4 960615 960687 73 - 1.668 1.775 0.361
ENSG00000145214 E006 46.674042 0.0004764497 4.264658e-01 5.692900e-01 4 960688 960721 34 - 1.600 1.646 0.156
ENSG00000145214 E007 77.490590 0.0003536522 1.616009e-01 2.771892e-01 4 961049 961201 153 - 1.804 1.867 0.211
ENSG00000145214 E008 74.661643 0.0010191912 4.636190e-01 6.033921e-01 4 961467 961578 112 - 1.807 1.843 0.121
ENSG00000145214 E009 81.662587 0.0014327689 9.217299e-01 9.546104e-01 4 961688 961834 147 - 1.867 1.875 0.026
ENSG00000145214 E010 78.292562 0.0007753490 4.641934e-01 6.039506e-01 4 961982 962082 101 - 1.875 1.846 -0.098
ENSG00000145214 E011 87.686417 0.0025098193 4.460378e-02 9.946971e-02 4 962435 962613 179 - 1.964 1.879 -0.288
ENSG00000145214 E012 61.185460 0.0005845417 4.049155e-01 5.485949e-01 4 962772 962920 149 - 1.720 1.762 0.145
ENSG00000145214 E013 34.112560 0.0006226633 4.926512e-01 6.297871e-01 4 963139 963141 3 - 1.469 1.515 0.158
ENSG00000145214 E014 77.749074 0.0007556039 8.795679e-01 9.266830e-01 4 963142 963290 149 - 1.842 1.852 0.032
ENSG00000145214 E015 11.538389 0.0016428105 1.110425e-03 4.337996e-03 4 964073 964093 21 - 1.248 0.930 -1.151
ENSG00000145214 E016 59.004374 0.0041560428 8.451834e-02 1.666259e-01 4 965176 965291 116 - 1.792 1.702 -0.304
ENSG00000145214 E017 37.441905 0.0005815680 2.875062e-01 4.280060e-01 4 965491 965529 39 - 1.580 1.518 -0.212
ENSG00000145214 E018 36.541557 0.0006585267 4.528961e-17 2.030284e-15 4 965530 965927 398 - 1.804 1.322 -1.651
ENSG00000145214 E019 45.414008 0.0005242859 3.467033e-02 8.101675e-02 4 965928 966063 136 - 1.701 1.589 -0.380
ENSG00000145214 E020 28.230635 0.0007128406 4.855192e-01 6.233914e-01 4 966064 966078 15 - 1.455 1.409 -0.159
ENSG00000145214 E021 15.306788 0.0012309357 1.747551e-01 2.943928e-01 4 966079 966150 72 - 1.248 1.129 -0.423
ENSG00000145214 E022 23.355273 0.0008805038 1.571012e-02 4.208476e-02 4 966151 966301 151 - 1.455 1.281 -0.606
ENSG00000145214 E023 42.357079 0.0199259684 2.399473e-01 3.740817e-01 4 966466 966527 62 - 1.519 1.628 0.373
ENSG00000145214 E024 38.692565 0.0013495318 9.116262e-01 9.479121e-01 4 966748 966802 55 - 1.548 1.557 0.031
ENSG00000145214 E025 43.149008 0.0005412543 4.215273e-01 5.646714e-01 4 966964 967054 91 - 1.564 1.612 0.164
ENSG00000145214 E026 61.483214 0.0082856655 3.597480e-01 5.040766e-01 4 967129 967361 233 - 1.785 1.736 -0.166
ENSG00000145214 E027 39.413056 0.0057259075 2.534286e-01 3.899457e-01 4 967549 967649 101 - 1.610 1.537 -0.248
ENSG00000145214 E028 28.244056 0.0008119598 7.403060e-03 2.226630e-02 4 967728 967802 75 - 1.536 1.359 -0.612
ENSG00000145214 E029 6.197979 0.0027744136 1.468560e-02 3.977955e-02 4 967803 967879 77 - 1.001 0.698 -1.176
ENSG00000145214 E030 28.593218 0.0405517659 2.369551e-01 3.706460e-01 4 967880 968027 148 - 1.514 1.388 -0.435
ENSG00000145214 E031 14.866756 0.0410499432 6.429187e-02 1.338539e-01 4 968282 968290 9 - 1.300 1.080 -0.782
ENSG00000145214 E032 36.174131 0.0242331465 2.587707e-01 3.960905e-01 4 968291 968407 117 - 1.595 1.499 -0.330
ENSG00000145214 E033 33.470149 0.0099047710 9.550949e-01 9.758115e-01 4 968479 968564 86 - 1.488 1.496 0.027
ENSG00000145214 E034 35.196570 0.0047228356 4.150021e-01 5.584148e-01 4 968811 968910 100 - 1.469 1.530 0.209
ENSG00000145214 E035 29.424218 0.0021763869 4.608855e-02 1.021974e-01 4 970993 971072 80 - 1.525 1.390 -0.464
ENSG00000145214 E036 23.831002 0.0156274139 1.551616e-03 5.803191e-03 4 973212 973569 358 - 1.530 1.246 -0.985
ENSG00000145214 E037 1.333885 0.0104771437 1.068262e-01 2.008625e-01 4 986806 986895 90 - 0.513 0.232 -1.679