ENSG00000145191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432569 ENSG00000145191 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B5 protein_coding protein_coding 30.7696 42.1138 23.27022 1.162342 1.337913 -0.8555307 2.622392 3.813814 1.493256 0.3112428 0.3005768 -1.346922 0.08267917 0.09030000 0.06316667 -0.02713333 2.319870e-01 2.04689e-11 FALSE FALSE
ENST00000465218 ENSG00000145191 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B5 protein_coding retained_intron 30.7696 42.1138 23.27022 1.162342 1.337913 -0.8555307 1.944392 1.253820 1.883257 0.1747588 0.3066402 0.583079 0.07047917 0.02956667 0.08220000 0.05263333 6.042526e-03 2.04689e-11 TRUE TRUE
ENST00000648915 ENSG00000145191 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B5 protein_coding protein_coding 30.7696 42.1138 23.27022 1.162342 1.337913 -0.8555307 19.180588 32.124557 12.361832 0.9945431 0.1469139 -1.377066 0.59968333 0.76266667 0.53393333 -0.22873333 2.046890e-11 2.04689e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145191 E001 20.4487411 0.0110889706 1.279771e-01 2.313442e-01 3 184135038 184135336 299 + 1.377 1.247 -0.456
ENSG00000145191 E002 14.9696152 0.0012958370 6.538846e-01 7.642309e-01 3 184135337 184135354 18 + 1.189 1.159 -0.108
ENSG00000145191 E003 14.4212929 0.0012745663 6.526630e-01 7.633353e-01 3 184135355 184135357 3 + 1.175 1.145 -0.110
ENSG00000145191 E004 14.9727357 0.0012149505 8.184628e-01 8.852574e-01 3 184135358 184135362 5 + 1.175 1.165 -0.036
ENSG00000145191 E005 14.7826253 0.0024709660 7.654467e-01 8.482194e-01 3 184135363 184135364 2 + 1.175 1.158 -0.061
ENSG00000145191 E006 15.2255157 0.0014409398 8.769812e-01 9.250110e-01 3 184135365 184135365 1 + 1.175 1.172 -0.012
ENSG00000145191 E007 22.2338925 0.0015034497 6.878399e-01 7.900879e-01 3 184135366 184135374 9 + 1.293 1.336 0.150
ENSG00000145191 E008 23.2344838 0.0012938454 9.397113e-01 9.661331e-01 3 184135375 184135375 1 + 1.332 1.349 0.059
ENSG00000145191 E009 23.4568740 0.0009550012 9.921900e-01 9.992207e-01 3 184135376 184135376 1 + 1.342 1.354 0.042
ENSG00000145191 E010 23.6083894 0.0010773590 9.120973e-01 9.482614e-01 3 184135377 184135378 2 + 1.351 1.354 0.010
ENSG00000145191 E011 31.0906942 0.0036623378 7.781059e-01 8.572262e-01 3 184135379 184135384 6 + 1.476 1.467 -0.028
ENSG00000145191 E012 37.9086448 0.0033189832 7.133995e-01 8.099105e-01 3 184135385 184135388 4 + 1.527 1.563 0.125
ENSG00000145191 E013 42.0662221 0.0182483820 6.692035e-01 7.760607e-01 3 184135389 184135391 3 + 1.614 1.585 -0.098
ENSG00000145191 E014 51.2364183 0.0055362914 3.444951e-01 4.885875e-01 3 184135392 184135399 8 + 1.711 1.662 -0.164
ENSG00000145191 E015 54.6675091 0.0020846809 3.690066e-01 5.134384e-01 3 184135400 184135402 3 + 1.730 1.692 -0.128
ENSG00000145191 E016 87.3349645 0.0004188502 7.980697e-01 8.711319e-01 3 184135403 184135436 34 + 1.889 1.911 0.074
ENSG00000145191 E017 117.2029704 0.0011193420 3.464003e-01 4.905331e-01 3 184135437 184135493 57 + 2.047 2.022 -0.085
ENSG00000145191 E018 101.5255764 0.0003580204 4.572250e-01 5.975888e-01 3 184135494 184135518 25 + 1.980 1.963 -0.057
ENSG00000145191 E019 89.2474884 0.0003220688 5.652806e-01 6.923954e-01 3 184135519 184135520 2 + 1.922 1.910 -0.040
ENSG00000145191 E020 173.5757208 0.0022567521 4.819218e-01 6.201089e-01 3 184135521 184135580 60 + 2.212 2.197 -0.052
ENSG00000145191 E021 2.1120863 0.0069987926 3.266302e-02 7.712906e-02 3 184135581 184135663 83 + 0.675 0.330 -1.714
ENSG00000145191 E022 1.9594250 0.0072412764 2.078721e-01 3.359330e-01 3 184135664 184135748 85 + 0.579 0.374 -1.036
ENSG00000145191 E023 3.4310193 0.0045776239 3.128679e-01 4.553889e-01 3 184135749 184135900 152 + 0.715 0.571 -0.621
ENSG00000145191 E024 2.0314431 0.0077772193 5.919518e-01 7.145908e-01 3 184135901 184135916 16 + 0.380 0.484 0.549
ENSG00000145191 E025 2.5182415 0.0760708390 8.939002e-01 9.361559e-01 3 184135917 184135951 35 + 0.523 0.514 -0.042
ENSG00000145191 E026 169.7714201 0.0002816783 2.021569e-01 3.288936e-01 3 184136612 184136648 37 + 2.211 2.185 -0.087
ENSG00000145191 E027 162.0871431 0.0031721563 9.078919e-02 1.763786e-01 3 184136649 184136666 18 + 2.212 2.154 -0.195
ENSG00000145191 E028 146.1013592 0.0035058405 8.559415e-02 1.683540e-01 3 184136667 184136675 9 + 2.171 2.107 -0.213
ENSG00000145191 E029 132.5296100 0.0007338614 1.550831e-02 4.164655e-02 3 184136676 184136678 3 + 2.135 2.063 -0.242
ENSG00000145191 E030 139.7421774 0.0011851811 5.913373e-02 1.251517e-01 3 184136679 184136682 4 + 2.147 2.091 -0.187
ENSG00000145191 E031 137.6863129 0.0002970829 1.030038e-02 2.950604e-02 3 184136683 184136684 2 + 2.151 2.080 -0.239
ENSG00000145191 E032 217.0495872 0.0002909730 3.048443e-01 4.468677e-01 3 184136685 184136736 52 + 2.310 2.294 -0.052
ENSG00000145191 E033 69.0457736 0.0003837030 5.727687e-01 6.988427e-01 3 184136737 184137431 695 + 1.818 1.804 -0.047
ENSG00000145191 E034 5.8409196 0.0027680463 5.494041e-09 7.118730e-08 3 184137432 184137530 99 + 1.175 0.450 -2.943
ENSG00000145191 E035 5.7690153 0.0028360640 5.373966e-12 1.168463e-10 3 184137531 184137619 89 + 1.214 0.330 -3.758
ENSG00000145191 E036 337.8124270 0.0003815797 4.488710e-04 1.962549e-03 3 184137620 184137805 186 + 2.536 2.471 -0.216
ENSG00000145191 E037 7.6751827 0.0033092123 2.104680e-10 3.512690e-09 3 184137806 184137873 68 + 1.272 0.544 -2.823
ENSG00000145191 E038 4.9296621 0.0042323612 3.435911e-05 2.013434e-04 3 184137874 184137897 24 + 1.051 0.515 -2.174
ENSG00000145191 E039 341.8511777 0.0001631903 2.991395e-06 2.238902e-05 3 184137898 184138075 178 + 2.553 2.469 -0.279
ENSG00000145191 E040 1.5092494 0.0091288842 1.594908e-04 7.895645e-04 3 184138144 184138165 22 + 0.715 0.089 -4.205
ENSG00000145191 E041 263.1757213 0.0001874932 1.506870e-07 1.478683e-06 3 184138166 184138246 81 + 2.456 2.346 -0.368
ENSG00000145191 E042 4.1028435 0.0075935345 3.468201e-01 4.909661e-01 3 184138847 184138939 93 + 0.753 0.622 -0.549
ENSG00000145191 E043 1.1844606 0.0103585968 1.414038e-02 3.854519e-02 3 184140057 184140079 23 + 0.579 0.163 -2.622
ENSG00000145191 E044 268.2089544 0.0001867688 3.771541e-08 4.165493e-07 3 184140080 184140148 69 + 2.466 2.351 -0.383
ENSG00000145191 E045 145.3284597 0.0008095817 1.315608e-03 5.028712e-03 3 184140149 184140157 9 + 2.188 2.093 -0.321
ENSG00000145191 E046 4.5664648 0.0035689353 6.374829e-04 2.671467e-03 3 184140158 184140221 64 + 0.973 0.515 -1.882
ENSG00000145191 E047 5.8198624 0.1014954270 1.322241e-02 3.642976e-02 3 184140222 184140417 196 + 1.052 0.625 -1.675
ENSG00000145191 E048 377.1799527 0.0002222781 2.378988e-03 8.395592e-03 3 184140418 184140615 198 + 2.571 2.521 -0.165
ENSG00000145191 E049 290.4249807 0.0001739365 2.290907e-01 3.613430e-01 3 184140616 184140730 115 + 2.434 2.418 -0.052
ENSG00000145191 E050 6.7213107 0.0024437488 1.964626e-03 7.115267e-03 3 184140731 184140740 10 + 1.069 0.707 -1.389
ENSG00000145191 E051 8.0050457 0.0576897586 2.521821e-02 6.232407e-02 3 184140741 184140908 168 + 1.117 0.784 -1.253
ENSG00000145191 E052 3.9555851 0.0058297448 3.000203e-03 1.026530e-02 3 184141867 184141920 54 + 0.903 0.484 -1.771
ENSG00000145191 E053 4.6595624 0.0488660282 1.167265e-02 3.275267e-02 3 184141921 184141924 4 + 0.951 0.548 -1.647
ENSG00000145191 E054 366.1255293 0.0001381972 5.500884e-01 6.797596e-01 3 184141925 184142070 146 + 2.524 2.524 -0.001
ENSG00000145191 E055 0.7395785 0.1801550970 5.140636e-01 6.488116e-01 3 184142108 184142236 129 + 0.286 0.166 -0.999
ENSG00000145191 E056 270.7446496 0.0006846303 8.861445e-01 9.311935e-01 3 184142237 184142297 61 + 2.381 2.395 0.048
ENSG00000145191 E057 338.1248717 0.0012691079 6.922015e-01 7.935007e-01 3 184142298 184142378 81 + 2.473 2.494 0.068
ENSG00000145191 E058 2.3302075 0.0069756714 7.807974e-01 8.591719e-01 3 184142379 184142394 16 + 0.522 0.484 -0.188
ENSG00000145191 E059 365.7225773 0.0009612614 2.653683e-03 9.234103e-03 3 184142502 184142603 102 + 2.460 2.546 0.286
ENSG00000145191 E060 358.6797123 0.0010635761 9.203061e-05 4.845322e-04 3 184142779 184142886 108 + 2.433 2.545 0.376
ENSG00000145191 E061 295.9877119 0.0002150514 1.073116e-05 7.081849e-05 3 184143052 184143142 91 + 2.346 2.462 0.385
ENSG00000145191 E062 42.2812011 0.0005356073 1.711581e-13 4.712309e-12 3 184143143 184143430 288 + 1.830 1.444 -1.313
ENSG00000145191 E063 17.6355834 0.0010962346 1.426945e-04 7.151223e-04 3 184143431 184143441 11 + 1.425 1.130 -1.037
ENSG00000145191 E064 355.8058876 0.0015293916 2.070431e-08 2.406657e-07 3 184143442 184143565 124 + 2.383 2.553 0.566
ENSG00000145191 E065 49.2798872 0.0011782747 1.001054e-18 5.532283e-17 3 184143566 184144078 513 + 1.922 1.475 -1.514
ENSG00000145191 E066 11.3544130 0.0015306943 2.217367e-07 2.107322e-06 3 184144079 184144098 20 + 1.342 0.853 -1.773
ENSG00000145191 E067 233.1896930 0.0002104597 7.038571e-08 7.360138e-07 3 184144099 184144127 29 + 2.210 2.366 0.521
ENSG00000145191 E068 347.6737440 0.0004728061 2.573774e-12 5.911662e-11 3 184144128 184144224 97 + 2.367 2.544 0.592
ENSG00000145191 E069 1.9476950 0.0079235061 5.933895e-01 7.157967e-01 3 184144225 184144596 372 + 0.380 0.483 0.547
ENSG00000145191 E070 357.1719271 0.0028409361 7.256216e-10 1.104749e-08 3 184144597 184144707 111 + 2.346 2.564 0.726
ENSG00000145191 E071 8.1456820 0.0034678226 9.608407e-01 9.793476e-01 3 184144708 184144883 176 + 0.903 0.918 0.059
ENSG00000145191 E072 533.3652620 0.0022214131 3.464681e-11 6.600699e-10 3 184144884 184146127 1244 + 2.535 2.734 0.663