ENSG00000145087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000471454 ENSG00000145087 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP5L protein_coding protein_coding 2.515781 3.679596 2.779954 0.5737095 0.1714686 -0.4032216 0.1783455 0.04286651 0.3162830 0.02345379 0.03367261 2.625698 0.08642083 0.01336667 0.1136333 0.1002667 2.958795e-04 2.647699e-18 FALSE TRUE
ENST00000472879 ENSG00000145087 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP5L protein_coding protein_coding 2.515781 3.679596 2.779954 0.5737095 0.1714686 -0.4032216 0.4266301 0.00000000 0.9227369 0.00000000 0.07283833 6.543398 0.18776250 0.00000000 0.3328000 0.3328000 2.647699e-18 2.647699e-18 FALSE TRUE
MSTRG.23521.2 ENSG00000145087 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP5L protein_coding   2.515781 3.679596 2.779954 0.5737095 0.1714686 -0.4032216 1.8539327 3.54030817 1.4994278 0.57865618 0.12930908 -1.233942 0.70185417 0.95950000 0.5385000 -0.4210000 9.758546e-16 2.647699e-18 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145087 E001 0.1515154 0.0423049717 1.000000e+00   3 120908072 120908162 91 + 0.084 0.000 -7.955
ENSG00000145087 E002 0.9276256 0.0854223691 1.776154e-01 2.981376e-01 3 120908163 120908204 42 + 0.155 0.398 1.808
ENSG00000145087 E003 5.6046137 0.0035977556 4.607214e-05 2.618730e-04 3 120908205 120908235 31 + 0.553 1.056 2.015
ENSG00000145087 E004 10.9199153 0.0017455393 1.095921e-07 1.105355e-06 3 120908236 120908288 53 + 0.803 1.307 1.849
ENSG00000145087 E005 11.3973654 0.0016159315 7.234372e-06 4.963530e-05 3 120908289 120908313 25 + 0.871 1.286 1.511
ENSG00000145087 E006 10.4739019 0.0017582500 1.509745e-08 1.800319e-07 3 120908314 120908334 21 + 0.757 1.307 2.034
ENSG00000145087 E007 0.2955422 0.0306387156 5.181721e-01   3 120909102 120909191 90 + 0.084 0.174 1.204
ENSG00000145087 E008 31.6390305 0.0008021709 2.508642e-19 1.487030e-17 3 120909571 120909767 197 + 1.238 1.744 1.742
ENSG00000145087 E009 17.8775582 0.0012031437 2.617846e-21 1.943351e-19 3 120916321 120916599 279 + 0.831 1.581 2.682
ENSG00000145087 E010 3.6060248 0.0098982134 1.361883e-02 3.735247e-02 3 120954940 120954943 4 + 0.757 0.299 -2.254
ENSG00000145087 E011 6.0032622 0.0029520948 6.774705e-04 2.816616e-03 3 120954944 120955037 94 + 0.951 0.395 -2.418
ENSG00000145087 E012 4.9282713 0.0034404714 4.870995e-03 1.557040e-02 3 121041700 121041781 82 + 0.871 0.395 -2.116
ENSG00000145087 E013 3.8921038 0.0042460235 6.864445e-03 2.087330e-02 3 121045435 121045535 101 + 0.788 0.299 -2.378
ENSG00000145087 E014 5.5894003 0.0032943018 7.182497e-03 2.169770e-02 3 121114925 121115059 135 + 0.907 0.474 -1.838
ENSG00000145087 E015 5.3934147 0.0319596113 1.320889e-04 6.679617e-04 3 121121641 121121704 64 + 0.930 0.175 -3.924
ENSG00000145087 E016 5.2526221 0.0573599992 4.745466e-04 2.062669e-03 3 121152477 121152560 84 + 0.919 0.175 -3.884
ENSG00000145087 E017 5.5916790 0.0029912290 2.438508e-04 1.149489e-03 3 121157504 121157627 124 + 0.929 0.299 -2.922
ENSG00000145087 E018 0.5138669 0.0207400133 8.722768e-01 9.218568e-01 3 121157628 121158968 1341 + 0.155 0.175 0.209
ENSG00000145087 E019 3.4825969 0.0045579491 2.253422e-03 8.009908e-03 3 121205923 121206001 79 + 0.757 0.175 -3.252
ENSG00000145087 E020 4.9082981 0.0034978731 6.401948e-03 1.966772e-02 3 121223003 121223157 155 + 0.858 0.395 -2.065
ENSG00000145087 E021 3.5742966 0.0046544961 6.748724e-02 1.391714e-01 3 121233616 121233688 73 + 0.723 0.395 -1.529
ENSG00000145087 E022 4.5072223 0.0036155063 5.105136e-02 1.110432e-01 3 121238971 121239118 148 + 0.803 0.474 -1.436
ENSG00000145087 E023 3.6820192 0.0462139337 9.165672e-02 1.777178e-01 3 121240440 121240507 68 + 0.740 0.396 -1.593
ENSG00000145087 E024 2.8274424 0.0572728681 2.817398e-01 4.216582e-01 3 121250723 121250763 41 + 0.624 0.397 -1.100
ENSG00000145087 E025 6.8678394 0.0025154928 1.178653e-02 3.302162e-02 3 121254895 121255112 218 + 0.971 0.598 -1.493
ENSG00000145087 E026 6.7214190 0.0026263061 1.879041e-01 3.110925e-01 3 121257161 121257333 173 + 0.929 0.736 -0.753
ENSG00000145087 E027 5.1380872 0.0180970469 2.895763e-01 4.302729e-01 3 121259043 121259168 126 + 0.831 0.648 -0.746
ENSG00000145087 E028 5.0085346 0.0498507616 4.576978e-04 1.997362e-03 3 121279805 121279956 152 + 0.906 0.174 -3.839
ENSG00000145087 E029 0.0000000       3 121282266 121282337 72 +      
ENSG00000145087 E030 3.3979054 0.0046154456 1.301743e-04 6.596000e-04 3 121318475 121318540 66 + 0.773 0.000 -13.600
ENSG00000145087 E031 0.0000000       3 121324493 121324585 93 +      
ENSG00000145087 E032 5.4753114 0.0668549663 3.316167e-04 1.507108e-03 3 121378716 121378886 171 + 0.940 0.174 -3.969
ENSG00000145087 E033 5.5241617 0.0290995796 1.414569e-02 3.855691e-02 3 121381293 121381532 240 + 0.906 0.473 -1.840
ENSG00000145087 E034 8.2436566 0.0021716438 5.694164e-03 1.780161e-02 3 121407243 121407603 361 + 1.036 0.650 -1.508
ENSG00000145087 E035 1.8028145 0.0080996446 8.901587e-01 9.338267e-01 3 121407604 121407668 65 + 0.434 0.395 -0.206
ENSG00000145087 E036 2.3971237 0.0062569796 2.177979e-02 5.521661e-02 3 121413158 121413323 166 + 0.625 0.174 -2.700
ENSG00000145087 E037 1.8080138 0.0084459768 7.739606e-02 1.552938e-01 3 121415857 121415968 112 + 0.526 0.174 -2.252
ENSG00000145087 E038 1.9679603 0.0084052092 6.251634e-01 7.413375e-01 3 121418337 121418557 221 + 0.497 0.395 -0.532
ENSG00000145087 E039 25.0698668 0.0010112702 2.225314e-06 1.713457e-05 3 121419056 121424761 5706 + 1.494 1.093 -1.409