ENSG00000145041

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335891 ENSG00000145041 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF1 protein_coding protein_coding 18.09041 14.32358 21.02496 1.503344 0.1602563 0.5533896 2.517625 5.82205507 0.000000 1.07089337 0.0000000 -9.1878605 0.1671958 0.404866667 0.0000000 -0.40486667 1.803853e-31 1.803853e-31 FALSE TRUE
ENST00000423656 ENSG00000145041 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF1 protein_coding protein_coding 18.09041 14.32358 21.02496 1.503344 0.1602563 0.5533896 2.505715 2.47841448 3.163068 0.41270755 0.1653351 0.3506518 0.1506458 0.170633333 0.1503667 -0.02026667 6.228867e-01 1.803853e-31 FALSE TRUE
ENST00000684031 ENSG00000145041 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF1 protein_coding protein_coding 18.09041 14.32358 21.02496 1.503344 0.1602563 0.5533896 9.531483 5.47234131 13.263570 0.95727208 0.4219233 1.2756924 0.5036000 0.382133333 0.6307000 0.24856667 3.502303e-03 1.803853e-31 FALSE TRUE
MSTRG.23016.16 ENSG00000145041 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF1 protein_coding   18.09041 14.32358 21.02496 1.503344 0.1602563 0.5533896 2.519367 0.07399147 4.132848 0.07399147 0.3474023 5.6242362 0.1271708 0.006433333 0.1967667 0.19033333 7.030291e-04 1.803853e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145041 E001 1.1717857 0.0118016133 1.187868e-01 2.182177e-01 3 51389893 51390928 1036 - 0.190 0.467 1.821
ENSG00000145041 E002 0.0000000       3 51390929 51391081 153 -      
ENSG00000145041 E003 0.0000000       3 51391082 51391219 138 -      
ENSG00000145041 E004 0.0000000       3 51391220 51391245 26 -      
ENSG00000145041 E005 0.0000000       3 51391246 51391271 26 -      
ENSG00000145041 E006 1.2867549 0.0627804830 1.296626e-01 2.336799e-01 3 51391272 51391563 292 - 0.190 0.470 1.836
ENSG00000145041 E007 4.9662163 0.0031750559 2.851170e-01 4.254187e-01 3 51391564 51395866 4303 - 0.708 0.857 0.592
ENSG00000145041 E008 132.6227936 0.0029082104 6.018902e-11 1.100109e-09 3 51395867 51397124 1258 - 1.985 2.254 0.903
ENSG00000145041 E009 35.2813350 0.0008529736 1.185459e-01 2.178606e-01 3 51397125 51397841 717 - 1.515 1.615 0.341
ENSG00000145041 E010 236.6944481 0.0097504378 4.359401e-14 1.304288e-12 3 51397842 51398469 628 - 2.143 2.550 1.357
ENSG00000145041 E011 182.6061425 0.0026662950 9.545505e-09 1.181708e-07 3 51398470 51398666 197 - 2.156 2.368 0.706
ENSG00000145041 E012 136.2527176 0.0002384939 3.800294e-09 5.059411e-08 3 51398667 51398734 68 - 2.045 2.232 0.625
ENSG00000145041 E013 167.1564000 0.0001989212 5.659903e-14 1.666281e-12 3 51398735 51398827 93 - 2.117 2.331 0.715
ENSG00000145041 E014 342.4499629 0.0009550373 8.546127e-07 7.203409e-06 3 51403143 51403391 249 - 2.479 2.601 0.406
ENSG00000145041 E015 115.3950664 0.0004040393 9.552669e-03 2.766528e-02 3 51403392 51403395 4 - 2.026 2.121 0.318
ENSG00000145041 E016 209.6909755 0.0003733232 2.967733e-03 1.016687e-02 3 51412379 51412480 102 - 2.288 2.371 0.278
ENSG00000145041 E017 184.9209189 0.0006169473 1.134166e-04 5.835691e-04 3 51412993 51413066 74 - 2.217 2.333 0.387
ENSG00000145041 E018 203.8680706 0.0007716050 1.088376e-03 4.264258e-03 3 51413282 51413386 105 - 2.267 2.364 0.322
ENSG00000145041 E019 189.5114237 0.0005102703 2.975073e-03 1.018881e-02 3 51413950 51414043 94 - 2.240 2.328 0.294
ENSG00000145041 E020 245.9670532 0.0012496636 1.384587e-01 2.459456e-01 3 51414624 51414857 234 - 2.372 2.416 0.150
ENSG00000145041 E021 116.0825357 0.0002937751 7.970847e-01 8.705122e-01 3 51416787 51416871 85 - 2.063 2.080 0.055
ENSG00000145041 E022 108.0638905 0.0003058695 3.142049e-01 4.568948e-01 3 51418116 51418198 83 - 2.020 2.062 0.142
ENSG00000145041 E023 161.2983131 0.0002151181 9.738764e-01 9.877135e-01 3 51418678 51418876 199 - 2.209 2.218 0.030
ENSG00000145041 E024 468.3208927 0.0002130302 1.465750e-02 3.972219e-02 3 51419734 51420950 1217 - 2.690 2.656 -0.111
ENSG00000145041 E025 80.1809179 0.0045149396 9.899025e-02 1.889321e-01 3 51420951 51420997 47 - 1.943 1.861 -0.277
ENSG00000145041 E026 117.6218377 0.0002902607 9.647208e-03 2.789686e-02 3 51422307 51422431 125 - 2.109 2.031 -0.262
ENSG00000145041 E027 78.9173604 0.0056838020 1.751465e-01 2.948713e-01 3 51427372 51427412 41 - 1.934 1.867 -0.224
ENSG00000145041 E028 124.1959894 0.0002819627 3.138609e-03 1.067313e-02 3 51427413 51427541 129 - 2.140 2.054 -0.291
ENSG00000145041 E029 135.9090412 0.0002247455 3.589862e-04 1.614952e-03 3 51429261 51429470 210 - 2.183 2.081 -0.341
ENSG00000145041 E030 113.8785475 0.0056926814 4.016069e-03 1.318662e-02 3 51430033 51430212 180 - 2.118 1.977 -0.475
ENSG00000145041 E031 72.1847918 0.0085983440 1.468796e-03 5.535842e-03 3 51433106 51433158 53 - 1.942 1.744 -0.668
ENSG00000145041 E032 88.0540932 0.0075768368 4.172575e-04 1.840513e-03 3 51433159 51433264 106 - 2.029 1.826 -0.682
ENSG00000145041 E033 95.0252781 0.0005929830 1.417959e-12 3.387919e-11 3 51440970 51441071 102 - 2.086 1.817 -0.905
ENSG00000145041 E034 228.3657464 0.0003377688 6.337834e-24 6.243805e-22 3 51441385 51441738 354 - 2.459 2.211 -0.826
ENSG00000145041 E035 145.2039636 0.0023013328 2.075986e-10 3.467549e-09 3 51441739 51441897 159 - 2.259 2.023 -0.789
ENSG00000145041 E036 125.5337969 0.0108606270 6.306054e-06 4.388433e-05 3 51443766 51443903 138 - 2.206 1.938 -0.897
ENSG00000145041 E037 106.2521574 0.0047385703 4.441061e-07 3.968237e-06 3 51463114 51463227 114 - 2.126 1.886 -0.806
ENSG00000145041 E038 48.7544360 0.0182928788 2.415144e-03 8.507340e-03 3 51466803 51466805 3 - 1.794 1.544 -0.848
ENSG00000145041 E039 72.5811237 0.0067540803 7.907160e-04 3.226058e-03 3 51466806 51466876 71 - 1.946 1.755 -0.642
ENSG00000145041 E040 65.4107089 0.0049521022 1.927032e-03 6.999452e-03 3 51470929 51471005 77 - 1.893 1.725 -0.566
ENSG00000145041 E041 76.9561254 0.0007435639 7.245322e-06 4.970503e-05 3 51483719 51483836 118 - 1.968 1.785 -0.618
ENSG00000145041 E042 0.2934659 0.0289498413 8.140925e-01   3 51483837 51483838 2 - 0.105 0.142 0.497
ENSG00000145041 E043 24.8894189 0.0008850166 6.882439e-05 3.744135e-04 3 51492389 51492488 100 - 1.519 1.237 -0.978
ENSG00000145041 E044 7.4983069 0.0581848953 2.732826e-01 4.122873e-01 3 51492489 51492513 25 - 1.001 0.812 -0.717
ENSG00000145041 E045 26.0464770 0.0008012413 3.302019e-07 3.028308e-06 3 51496734 51496780 47 - 1.566 1.206 -1.249
ENSG00000145041 E046 41.5204223 0.0005348237 4.601865e-04 2.007252e-03 3 51499873 51500065 193 - 1.711 1.525 -0.633