ENSG00000145016

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273582 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding protein_coding 6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 3.8158004 4.8659289 2.3078174 0.12068423 0.04397037 -1.0729102 0.56660417 0.64846667 0.44253333 -0.205933333 7.732055e-02 1.563668e-28 FALSE TRUE
ENST00000296343 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding protein_coding 6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 0.4782922 0.7123538 0.3566683 0.13125555 0.10847839 -0.9782302 0.07097917 0.09156667 0.07020000 -0.021366667 7.172651e-01 1.563668e-28 FALSE TRUE
ENST00000415452 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding protein_coding 6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 0.3833366 0.4433173 0.3492211 0.07638293 0.03713216 -0.3356490 0.05815417 0.05730000 0.06623333 0.008933333 8.191134e-01 1.563668e-28 FALSE TRUE
ENST00000471364 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding retained_intron 6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 0.5072288 0.3826567 0.4537696 0.22222690 0.35671191 0.2401398 0.07682083 0.04476667 0.07630000 0.031533333 9.787117e-01 1.563668e-28   FALSE
ENST00000474214 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding protein_coding 6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 0.2629620 0.8830164 0.0000000 0.26818786 0.00000000 -6.4806147 0.03622083 0.11100000 0.00000000 -0.111000000 4.569587e-07 1.563668e-28 TRUE FALSE
MSTRG.24376.8 ENSG00000145016 HEK293_OSMI2_2hA HEK293_TMG_2hB RUBCN protein_coding   6.610021 7.644236 5.2835 0.8128996 0.4505854 -0.5320365 0.6289038 0.0000000 1.5022093 0.00000000 0.09119347 7.2405140 0.10693333 0.00000000 0.28600000 0.286000000 1.563668e-28 1.563668e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145016 E001 22.869091 0.0026315455 1.755816e-03 6.458413e-03 3 197668867 197671392 2526 - 1.124 1.452 1.152
ENSG00000145016 E002 464.455126 0.0124381106 3.115330e-09 4.213234e-08 3 197671393 197674019 2627 - 2.416 2.750 1.112
ENSG00000145016 E003 119.871400 0.0002856424 1.087561e-02 3.087087e-02 3 197674020 197674495 476 - 1.961 2.118 0.527
ENSG00000145016 E004 36.518751 0.0006220002 6.403233e-01 7.535927e-01 3 197674496 197674576 81 - 1.496 1.594 0.335
ENSG00000145016 E005 49.893925 0.0004717767 7.095322e-01 8.068836e-01 3 197674577 197674741 165 - 1.655 1.707 0.175
ENSG00000145016 E006 38.771240 0.0074605259 2.874122e-01 4.279097e-01 3 197674742 197674930 189 - 1.480 1.628 0.505
ENSG00000145016 E007 5.115638 0.0031723812 6.155799e-01 7.338269e-01 3 197674931 197674949 19 - 0.685 0.814 0.521
ENSG00000145016 E008 15.740674 0.0077933423 3.051336e-01 4.471810e-01 3 197674950 197675007 58 - 1.084 1.253 0.603
ENSG00000145016 E009 33.780342 0.0279166377 9.053994e-01 9.437728e-01 3 197675008 197675196 189 - 1.463 1.553 0.310
ENSG00000145016 E010 29.954494 0.0010985389 4.892210e-01 6.266879e-01 3 197675422 197675515 94 - 1.395 1.511 0.400
ENSG00000145016 E011 5.990535 0.0039770334 2.154935e-01 3.450122e-01 3 197676217 197676884 668 - 0.685 0.912 0.898
ENSG00000145016 E012 44.970736 0.0105297250 1.160507e-01 2.143146e-01 3 197676885 197677038 154 - 1.673 1.635 -0.129
ENSG00000145016 E013 33.861873 0.0149745956 4.942569e-01 6.312099e-01 3 197677480 197677541 62 - 1.522 1.537 0.053
ENSG00000145016 E014 59.285098 0.0006429648 5.340538e-02 1.152137e-01 3 197681129 197681367 239 - 1.777 1.758 -0.064
ENSG00000145016 E015 30.351086 0.0007188380 1.404159e-01 2.486000e-01 3 197681835 197681899 65 - 1.496 1.472 -0.083
ENSG00000145016 E016 37.724744 0.0075554350 3.927062e-03 1.293793e-02 3 197682470 197682615 146 - 1.644 1.514 -0.443
ENSG00000145016 E017 34.434947 0.0012315638 8.356324e-04 3.386268e-03 3 197683307 197683439 133 - 1.608 1.477 -0.451
ENSG00000145016 E018 25.561153 0.0008434399 5.340131e-03 1.685754e-02 3 197684157 197684217 61 - 1.475 1.352 -0.422
ENSG00000145016 E019 3.309706 0.0046912755 8.003244e-01 8.727218e-01 3 197691074 197691148 75 - 0.567 0.661 0.413
ENSG00000145016 E020 29.027644 0.0040999752 3.511114e-02 8.185599e-02 3 197693715 197693816 102 - 1.502 1.423 -0.271
ENSG00000145016 E021 2.339509 0.2306569926 3.646538e-01 5.090006e-01 3 197693817 197693954 138 - 0.609 0.432 -0.844
ENSG00000145016 E022 27.304033 0.0223968260 2.077756e-01 3.358044e-01 3 197694375 197694416 42 - 1.457 1.412 -0.156
ENSG00000145016 E023 47.153054 0.0010000850 1.244732e-03 4.792754e-03 3 197694417 197694585 169 - 1.720 1.622 -0.334
ENSG00000145016 E024 42.568997 0.0020200379 1.121428e-05 7.365265e-05 3 197695866 197695981 116 - 1.723 1.547 -0.600
ENSG00000145016 E025 34.304516 0.0006624552 4.641281e-06 3.328703e-05 3 197696954 197697049 96 - 1.644 1.443 -0.687
ENSG00000145016 E026 0.000000       3 197699187 197699231 45 -      
ENSG00000145016 E027 1.133176 0.0753009011 2.867432e-01 4.271622e-01 3 197700460 197700612 153 - 0.141 0.379 1.861
ENSG00000145016 E028 44.036298 0.0098491319 1.685594e-02 4.461298e-02 3 197700613 197700800 188 - 1.694 1.602 -0.313
ENSG00000145016 E029 29.504791 0.0007389875 2.162598e-01 3.459041e-01 3 197700801 197700927 127 - 1.475 1.464 -0.036
ENSG00000145016 E030 42.138943 0.0005148660 2.560939e-05 1.548703e-04 3 197700928 197701146 219 - 1.710 1.556 -0.525
ENSG00000145016 E031 19.670178 0.0010059232 4.933483e-05 2.783719e-04 3 197701708 197701735 28 - 1.440 1.201 -0.834
ENSG00000145016 E032 28.044720 0.0007256991 2.135361e-03 7.643893e-03 3 197701736 197701859 124 - 1.527 1.397 -0.446
ENSG00000145016 E033 10.837445 0.0016732463 2.568289e-02 6.328342e-02 3 197701860 197701864 5 - 1.148 0.992 -0.567
ENSG00000145016 E034 17.327564 0.0012362125 1.856654e-01 3.083254e-01 3 197703548 197703654 107 - 1.271 1.230 -0.145
ENSG00000145016 E035 23.954520 0.0009412568 3.097390e-03 1.055285e-02 3 197704542 197704701 160 - 1.463 1.325 -0.480
ENSG00000145016 E036 20.023996 0.0009788610 3.514219e-01 4.956472e-01 3 197705092 197705175 84 - 1.306 1.302 -0.014
ENSG00000145016 E037 15.366330 0.0023092771 6.626672e-03 2.025512e-02 3 197717977 197718130 154 - 1.289 1.119 -0.603
ENSG00000145016 E038 19.022294 0.0301852955 1.096005e-02 3.106726e-02 3 197736655 197736915 261 - 1.395 1.188 -0.724
ENSG00000145016 E039 2.773012 0.0162916420 7.808089e-01 8.591719e-01 3 197748109 197748445 337 - 0.567 0.574 0.032
ENSG00000145016 E040 5.833274 0.0052972372 6.375791e-01 7.514355e-01 3 197749269 197749727 459 - 0.830 0.831 0.003