ENSG00000145002

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000685726 ENSG00000145002 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86B2 protein_coding nonsense_mediated_decay 3.651649 6.287573 3.074606 0.7867798 0.503607 -1.02971 0.6409217 0.8172092 0.8219920 0.1092527 0.0546546 0.008317384 0.1885833 0.1327333 0.2807333 0.14800000 0.04637821 0.04637821 FALSE FALSE
MSTRG.31173.1 ENSG00000145002 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86B2 protein_coding   3.651649 6.287573 3.074606 0.7867798 0.503607 -1.02971 1.3865826 2.0440492 1.2851875 0.1845723 0.1037440 -0.665309756 0.4243458 0.3452333 0.4436667 0.09843333 0.72042541 0.04637821   FALSE
MSTRG.31173.2 ENSG00000145002 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86B2 protein_coding   3.651649 6.287573 3.074606 0.7867798 0.503607 -1.02971 1.3724379 3.1458444 0.7799397 0.8970751 0.4238797 -1.998211722 0.3024667 0.4770000 0.2189667 -0.25803333 0.50765206 0.04637821   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000145002 E001 0.7384326 0.1167026564 1.00000000 1.00000000 8 12195862 12195956 95 - 0.191 0.199 0.077
ENSG00000145002 E002 27.0991225 0.0009074458 0.42314444 0.56626199 8 12195957 12196206 250 - 1.330 1.391 0.211
ENSG00000145002 E003 0.1817044 0.0413506327 1.00000000   8 12424411 12424412 2 - 0.000 0.076 10.186
ENSG00000145002 E004 0.1817044 0.0413506327 1.00000000   8 12424413 12424418 6 - 0.000 0.076 10.186
ENSG00000145002 E005 0.1817044 0.0413506327 1.00000000   8 12424419 12424420 2 - 0.000 0.076 10.186
ENSG00000145002 E006 15.0451100 0.0289227676 0.02957646 0.07112701 8 12424421 12425344 924 - 1.283 1.081 -0.719
ENSG00000145002 E007 0.0000000       8 12425345 12425403 59 -      
ENSG00000145002 E008 0.0000000       8 12425404 12425760 357 -      
ENSG00000145002 E009 0.0000000       8 12425761 12425989 229 -      
ENSG00000145002 E010 0.0000000       8 12427515 12427656 142 -      
ENSG00000145002 E011 0.0000000       8 12427657 12427806 150 -      
ENSG00000145002 E012 0.6621732 0.0221281828 0.29210214 0.43304099 8 12428633 12428898 266 - 0.323 0.141 -1.520
ENSG00000145002 E013 0.6998377 0.0178373296 0.29708737 0.43839423 8 12428981 12429107 127 - 0.323 0.141 -1.519
ENSG00000145002 E014 0.8481309 0.0145581898 0.47971527 0.61804572 8 12429108 12429114 7 - 0.323 0.198 -0.936
ENSG00000145002 E015 3.5657969 0.0053796136 0.02828273 0.06856760 8 12430350 12430451 102 - 0.814 0.494 -1.382
ENSG00000145002 E016 1.6178984 0.0125309042 0.60860630 0.72829530 8 12430589 12430702 114 - 0.424 0.333 -0.518
ENSG00000145002 E017 19.7501732 0.0036155063 0.01073411 0.03053234 8 12432082 12432162 81 - 1.060 1.292 0.828
ENSG00000145002 E018 0.9233592 0.0902542912 0.49748809 0.63404932 8 12434052 12434114 63 - 0.323 0.200 -0.918
ENSG00000145002 E019 0.0000000       8 12435355 12435392 38 -      
ENSG00000145002 E020 14.3609215 0.0014449942 0.86213908 0.91511888 8 12436150 12436247 98 - 1.118 1.111 -0.026
ENSG00000145002 E021 1.6960583 0.0111454961 0.03092776 0.07377620 8 12436248 12436277 30 - 0.000 0.465 12.936
ENSG00000145002 E022 1.2511787 0.0110611423 0.08674260 0.17019445 8 12436278 12436406 129 - 0.000 0.370 12.552