ENSG00000144848

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283290 ENSG00000144848 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG3 protein_coding protein_coding 42.67506 31.56987 60.62613 2.231429 1.399009 0.9411723 39.8646 30.30368 54.62655 2.285131 1.487401 0.8498972 0.9407125 0.9592667 0.9009 -0.05836667 0.000231777 6.681953e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144848 E001 7.8181596 0.0211134644 1.792337e-01 3.001599e-01 3 112532510 112532517 8 - 0.866 1.040 0.650
ENSG00000144848 E002 18.8463810 0.0087441122 6.888586e-01 7.909032e-01 3 112532518 112532521 4 - 1.312 1.276 -0.127
ENSG00000144848 E003 335.1685185 0.0002320368 9.899355e-16 3.738097e-14 3 112532522 112532780 259 - 2.450 2.607 0.525
ENSG00000144848 E004 72.6993902 0.0003434823 1.673912e-11 3.360366e-10 3 112532781 112534268 1488 - 1.966 1.660 -1.033
ENSG00000144848 E005 315.5537904 0.0004004125 1.360121e-07 1.347017e-06 3 112534269 112534337 69 - 2.448 2.559 0.367
ENSG00000144848 E006 9.5654022 0.0017397147 7.153960e-01 8.113215e-01 3 112534338 112536209 1872 - 1.005 1.042 0.136
ENSG00000144848 E007 3.0386823 0.0096235144 5.960380e-01 7.180268e-01 3 112536210 112536474 265 - 0.633 0.545 -0.394
ENSG00000144848 E008 489.4921030 0.0001392043 2.161901e-09 3.010406e-08 3 112536475 112536602 128 - 2.645 2.740 0.313
ENSG00000144848 E009 2.4002536 0.0062729049 4.852253e-01 6.231365e-01 3 112536603 112536767 165 - 0.481 0.594 0.528
ENSG00000144848 E010 0.5901394 0.3486936955 4.041534e-01 5.478641e-01 3 112537531 112537734 204 - 0.098 0.272 1.783
ENSG00000144848 E011 583.8336335 0.0001029032 5.470720e-04 2.336049e-03 3 112537735 112537890 156 - 2.742 2.791 0.160
ENSG00000144848 E012 351.9066341 0.0002309406 1.718612e-02 4.535443e-02 3 112538146 112538180 35 - 2.526 2.571 0.149
ENSG00000144848 E013 0.8762330 0.1957983153 3.626346e-01 5.070451e-01 3 112538181 112538344 164 - 0.355 0.150 -1.611
ENSG00000144848 E014 441.8995173 0.0001356787 8.693564e-01 9.200203e-01 3 112541803 112541884 82 - 2.645 2.640 -0.017
ENSG00000144848 E015 0.8931848 0.0352089871 2.750683e-01 4.143235e-01 3 112543995 112544056 62 - 0.356 0.151 -1.605
ENSG00000144848 E016 383.1213636 0.0001522565 1.985758e-01 3.244046e-01 3 112544057 112544106 50 - 2.592 2.566 -0.086
ENSG00000144848 E017 414.7917835 0.0006181984 7.302371e-02 1.483687e-01 3 112548533 112548614 82 - 2.631 2.592 -0.131
ENSG00000144848 E018 239.4735884 0.0001986630 4.392252e-03 1.424339e-02 3 112548615 112548640 26 - 2.405 2.335 -0.233
ENSG00000144848 E019 257.6658480 0.0001545342 4.602292e-06 3.303992e-05 3 112550192 112550218 27 - 2.451 2.345 -0.356
ENSG00000144848 E020 329.3047018 0.0001381582 9.472910e-07 7.897093e-06 3 112550219 112550262 44 - 2.555 2.454 -0.336
ENSG00000144848 E021 280.3968071 0.0002197379 1.551454e-04 7.699437e-04 3 112553280 112553329 50 - 2.480 2.393 -0.287
ENSG00000144848 E022 0.3030308 0.3821685305 4.964117e-01   3 112558138 112558375 238 - 0.179 0.000 -9.792
ENSG00000144848 E023 227.9419734 0.0007332272 1.328094e-03 5.069278e-03 3 112558376 112558417 42 - 2.390 2.301 -0.297
ENSG00000144848 E024 344.8260947 0.0059381308 2.279873e-01 3.600283e-01 3 112561457 112561845 389 - 2.558 2.499 -0.196
ENSG00000144848 E025 60.8391950 0.0020140085 1.520224e-01 2.644354e-01 3 112561846 112562046 201 - 1.817 1.742 -0.253