ENSG00000144749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273261 ENSG00000144749 HEK293_OSMI2_2hA HEK293_TMG_2hB LRIG1 protein_coding protein_coding 19.46973 14.32836 16.59815 0.5589737 0.1201135 0.2120115 13.472836 6.679062 14.2838289 1.18854934 0.5763680 1.095517 0.68102500 0.46256667 0.86030000 0.39773333 7.579223e-05 2.656581e-09 FALSE TRUE
ENST00000496559 ENSG00000144749 HEK293_OSMI2_2hA HEK293_TMG_2hB LRIG1 protein_coding processed_transcript 19.46973 14.32836 16.59815 0.5589737 0.1201135 0.2120115 4.291364 7.199921 0.6167892 0.69660851 0.2411709 -3.523931 0.24120417 0.50673333 0.03706667 -0.46966667 2.562467e-08 2.656581e-09 FALSE TRUE
MSTRG.23216.4 ENSG00000144749 HEK293_OSMI2_2hA HEK293_TMG_2hB LRIG1 protein_coding   19.46973 14.32836 16.59815 0.5589737 0.1201135 0.2120115 0.566216 0.146350 1.3677204 0.03883002 0.1381220 3.139432 0.03094583 0.01016667 0.08250000 0.07233333 2.656581e-09 2.656581e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144749 E001 1.0392854 0.0502796433 6.378521e-02 1.329988e-01 3 66378797 66378797 1 - 0.108 0.457 2.721
ENSG00000144749 E002 664.1285747 0.0055618376 6.946193e-14 2.017819e-12 3 66378798 66380073 1276 - 2.665 2.947 0.935
ENSG00000144749 E003 169.3961374 0.0012873147 4.539964e-03 1.465342e-02 3 66380074 66380224 151 - 2.168 2.289 0.405
ENSG00000144749 E004 222.1590947 0.0003863645 1.078921e-02 3.066190e-02 3 66380225 66380489 265 - 2.300 2.395 0.317
ENSG00000144749 E005 215.9087944 0.0002274236 1.455672e-01 2.556339e-01 3 66380577 66380861 285 - 2.300 2.368 0.226
ENSG00000144749 E006 169.5551171 0.0002316606 3.286411e-01 4.721251e-01 3 66381479 66381631 153 - 2.202 2.261 0.197
ENSG00000144749 E007 161.1640208 0.0002156871 3.526200e-01 4.968746e-01 3 66382273 66382398 126 - 2.179 2.237 0.195
ENSG00000144749 E008 261.7051179 0.0001682175 9.478882e-01 9.712484e-01 3 66382982 66383401 420 - 2.402 2.436 0.113
ENSG00000144749 E009 134.3938055 0.0002363293 2.175173e-01 3.473921e-01 3 66383991 66384131 141 - 2.095 2.165 0.234
ENSG00000144749 E010 133.7434771 0.0004749845 2.800737e-01 4.198712e-01 3 66384132 66384272 141 - 2.129 2.128 -0.005
ENSG00000144749 E011 180.5616964 0.0001994199 1.003048e-02 2.883745e-02 3 66385981 66386301 321 - 2.274 2.239 -0.118
ENSG00000144749 E012 105.3478010 0.0003462859 6.070752e-02 1.278214e-01 3 66394040 66394203 164 - 2.041 2.009 -0.110
ENSG00000144749 E013 82.3486145 0.0049888505 1.627892e-02 4.334068e-02 3 66398112 66398183 72 - 1.960 1.868 -0.309
ENSG00000144749 E014 80.3604965 0.0079059130 1.869504e-03 6.820575e-03 3 66398970 66399041 72 - 1.973 1.825 -0.500
ENSG00000144749 E015 0.4783925 0.0211967115 6.914513e-01 7.929298e-01 3 66401609 66401680 72 - 0.195 0.138 -0.598
ENSG00000144749 E016 0.8020473 0.0958699135 5.329045e-01 6.651809e-01 3 66404235 66404410 176 - 0.195 0.326 0.984
ENSG00000144749 E017 107.8208567 0.0005947788 2.368785e-08 2.721897e-07 3 66405198 66405278 81 - 2.106 1.938 -0.562
ENSG00000144749 E018 0.6621601 0.0166469014 8.397344e-01 8.998946e-01 3 66405753 66406213 461 - 0.195 0.243 0.402
ENSG00000144749 E019 125.5306813 0.0015074996 2.938217e-07 2.724470e-06 3 66407348 66407491 144 - 2.167 2.013 -0.516
ENSG00000144749 E020 0.0000000       3 66409754 66410128 375 -      
ENSG00000144749 E021 48.7159328 0.0004851546 1.375990e-02 3.767666e-02 3 66410129 66410150 22 - 1.736 1.644 -0.315
ENSG00000144749 E022 88.3987358 0.0002911950 3.304791e-03 1.116230e-02 3 66410151 66410272 122 - 1.985 1.907 -0.264
ENSG00000144749 E023 69.5580557 0.0003983981 9.467071e-02 1.823913e-01 3 66412871 66412925 55 - 1.866 1.827 -0.131
ENSG00000144749 E024 76.0257969 0.0003663279 4.959447e-02 1.084432e-01 3 66412926 66413014 89 - 1.908 1.860 -0.160
ENSG00000144749 E025 67.7829601 0.0003502066 2.768643e-06 2.088626e-05 3 66414920 66414957 38 - 1.911 1.739 -0.578
ENSG00000144749 E026 87.4232567 0.0003119079 2.988259e-07 2.766674e-06 3 66414958 66415063 106 - 2.017 1.853 -0.551
ENSG00000144749 E027 97.2019153 0.0014618232 1.429131e-04 7.161609e-04 3 66417129 66417266 138 - 2.044 1.925 -0.399
ENSG00000144749 E028 0.0000000       3 66417583 66417632 50 -      
ENSG00000144749 E029 0.4418608 0.0292037750 1.215179e-01 2.220988e-01 3 66451558 66451558 1 - 0.267 0.000 -10.166
ENSG00000144749 E030 61.5936571 0.0030601691 1.143588e-02 3.219922e-02 3 66451559 66451633 75 - 1.837 1.738 -0.334
ENSG00000144749 E031 47.2621112 0.0080329935 1.954186e-03 7.084500e-03 3 66462438 66462509 72 - 1.754 1.579 -0.596
ENSG00000144749 E032 0.0000000       3 66468985 66469245 261 -      
ENSG00000144749 E033 0.0000000       3 66498147 66498259 113 -      
ENSG00000144749 E034 86.5721368 0.0246721977 3.286424e-05 1.936225e-04 3 66500190 66501022 833 - 2.063 1.749 -1.055
ENSG00000144749 E035 0.3666179 0.0320116418 8.800732e-01 9.270865e-01 3 66501093 66501263 171 - 0.108 0.138 0.405