ENSG00000144741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336733 ENSG00000144741 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A26 protein_coding protein_coding 35.82633 62.16426 21.96698 2.639832 0.7666404 -1.500324 23.952550 41.3663867 14.017259 2.7438947 0.2604823 -1.560575 0.66202083 0.66450000 0.63883333 -0.02566667 7.642013e-01 4.189443e-21 FALSE TRUE
ENST00000354883 ENSG00000144741 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A26 protein_coding protein_coding 35.82633 62.16426 21.96698 2.639832 0.7666404 -1.500324 1.393086 0.8342515 1.879173 0.4243189 0.4637938 1.162010 0.05178750 0.01293333 0.08496667 0.07203333 1.686996e-01 4.189443e-21 FALSE TRUE
ENST00000676754 ENSG00000144741 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A26 protein_coding protein_coding 35.82633 62.16426 21.96698 2.639832 0.7666404 -1.500324 3.482745 8.4217270 0.000000 1.1551057 0.0000000 -9.719684 0.07798333 0.13656667 0.00000000 -0.13656667 4.189443e-21 4.189443e-21 FALSE TRUE
MSTRG.23213.21 ENSG00000144741 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A26 protein_coding   35.82633 62.16426 21.96698 2.639832 0.7666404 -1.500324 3.084163 7.1953517 2.227575 0.6387503 0.2923738 -1.687133 0.08281250 0.11620000 0.10146667 -0.01473333 7.894187e-01 4.189443e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144741 E001 0.0000000       3 66133610 66133984 375 +      
ENSG00000144741 E002 0.0000000       3 66220707 66220722 16 +      
ENSG00000144741 E003 0.0000000       3 66220723 66220731 9 +      
ENSG00000144741 E004 0.0000000       3 66220732 66220741 10 +      
ENSG00000144741 E005 1.7263490 0.0083029543 2.530556e-01 3.895180e-01 3 66220742 66220833 92 + 0.199 0.422 1.503
ENSG00000144741 E006 1.7263490 0.0083029543 2.530556e-01 3.895180e-01 3 66220834 66220858 25 + 0.199 0.422 1.503
ENSG00000144741 E007 0.0000000       3 66220859 66220903 45 +      
ENSG00000144741 E008 0.1451727 0.0426083215 1.489863e-01   3 66220904 66220959 56 + 0.199 0.000 -12.328
ENSG00000144741 E009 1.1717857 0.0114104036 7.978042e-01 8.709925e-01 3 66220960 66220988 29 + 0.334 0.282 -0.344
ENSG00000144741 E010 1.1717857 0.0114104036 7.978042e-01 8.709925e-01 3 66220989 66220991 3 + 0.334 0.282 -0.344
ENSG00000144741 E011 1.1717857 0.0114104036 7.978042e-01 8.709925e-01 3 66220992 66220996 5 + 0.334 0.282 -0.344
ENSG00000144741 E012 1.3534901 0.0125890055 9.642512e-01 9.814666e-01 3 66220997 66221000 4 + 0.334 0.321 -0.081
ENSG00000144741 E013 2.3562569 0.0062702675 7.158084e-01 8.116288e-01 3 66221001 66221006 6 + 0.521 0.451 -0.345
ENSG00000144741 E014 2.8409921 0.0177704149 3.292539e-01 4.727581e-01 3 66221007 66221008 2 + 0.651 0.478 -0.793
ENSG00000144741 E015 11.2517131 0.0016967801 7.992335e-02 1.594433e-01 3 66221009 66221011 3 + 1.156 0.964 -0.699
ENSG00000144741 E016 92.2766978 0.0108527793 3.978496e-02 9.062876e-02 3 66221012 66221063 52 + 1.985 1.843 -0.477
ENSG00000144741 E017 173.9599984 0.0036833564 6.947751e-02 1.424908e-01 3 66221064 66221127 64 + 2.216 2.131 -0.285
ENSG00000144741 E018 0.0000000       3 66230191 66230236 46 +      
ENSG00000144741 E019 0.0000000       3 66231786 66231872 87 +      
ENSG00000144741 E020 182.8249545 0.0055605360 3.368254e-01 4.806930e-01 3 66236544 66236700 157 + 2.146 2.179 0.109
ENSG00000144741 E021 0.0000000       3 66238565 66238695 131 +      
ENSG00000144741 E022 303.0041356 0.0017224920 5.579886e-01 6.863123e-01 3 66243203 66243312 110 + 2.414 2.387 -0.089
ENSG00000144741 E023 0.0000000       3 66261595 66261650 56 +      
ENSG00000144741 E024 365.1348872 0.0010037543 6.889801e-01 7.909660e-01 3 66262051 66262155 105 + 2.473 2.475 0.005
ENSG00000144741 E025 309.0604662 0.0001770563 6.320442e-01 7.469674e-01 3 66263332 66263379 48 + 2.400 2.404 0.013
ENSG00000144741 E026 1.5114395 0.0091000203 1.304695e-05 8.434417e-05 3 66276365 66278402 2038 + 0.794 0.073 -4.836
ENSG00000144741 E027 0.2934659 0.0288411199 4.069476e-01   3 66299236 66299469 234 + 0.199 0.073 -1.668
ENSG00000144741 E028 2.7102024 0.0822803813 6.184969e-01 7.361045e-01 3 66304453 66304537 85 + 0.591 0.479 -0.523
ENSG00000144741 E029 0.0000000       3 66304538 66305514 977 +      
ENSG00000144741 E030 0.1451727 0.0426083215 1.489863e-01   3 66336621 66337384 764 + 0.199 0.000 -12.328
ENSG00000144741 E031 0.0000000       3 66345287 66345346 60 +      
ENSG00000144741 E032 1.1760376 0.0234369842 1.384393e-01 2.459189e-01 3 66345996 66346363 368 + 0.000 0.322 12.218
ENSG00000144741 E033 258.6500167 0.0001800889 1.053026e-01 1.985514e-01 3 66346364 66346408 45 + 2.298 2.333 0.117
ENSG00000144741 E034 2.6509599 0.0259872926 1.768312e-04 8.646537e-04 3 66346409 66354145 7737 + 0.901 0.282 -2.929
ENSG00000144741 E035 2.2755922 0.5504958983 6.540461e-01 7.643567e-01 3 66356031 66356084 54 + 0.703 0.357 -1.664
ENSG00000144741 E036 318.6456754 0.0002483593 3.199375e-03 1.085464e-02 3 66362860 66362929 70 + 2.364 2.428 0.213
ENSG00000144741 E037 0.5138669 0.0217681645 1.251286e-01 2.273208e-01 3 66368392 66368546 155 + 0.334 0.073 -2.664
ENSG00000144741 E038 345.8839089 0.0008136142 2.522255e-03 8.828785e-03 3 66369478 66369542 65 + 2.394 2.464 0.233
ENSG00000144741 E039 351.1458157 0.0001702232 5.463699e-05 3.049020e-04 3 66370529 66370602 74 + 2.389 2.474 0.283
ENSG00000144741 E040 4.2252142 0.0949979681 1.149744e-01 2.127978e-01 3 66371202 66371413 212 + 0.869 0.554 -1.311
ENSG00000144741 E041 554.0775972 0.0005938326 2.757096e-05 1.654231e-04 3 66377690 66377967 278 + 2.594 2.670 0.255
ENSG00000144741 E042 128.9093340 0.0014555133 7.087315e-02 1.447951e-01 3 66377968 66378016 49 + 1.972 2.040 0.227
ENSG00000144741 E043 85.8531489 0.0003909438 1.550176e-01 2.684401e-01 3 66378017 66378070 54 + 1.807 1.866 0.197
ENSG00000144741 E044 25.7524876 0.0007924170 6.129006e-03 1.894750e-02 3 66378071 66378159 89 + 1.501 1.293 -0.722
ENSG00000144741 E045 31.1762210 0.0043010559 4.224170e-10 6.705122e-09 3 66378160 66378409 250 + 1.730 1.291 -1.507
ENSG00000144741 E046 23.6597186 0.0267295704 8.497638e-04 3.436770e-03 3 66378410 66378502 93 + 1.561 1.217 -1.193
ENSG00000144741 E047 10.0005635 0.0255861167 5.569620e-03 1.747425e-02 3 66378503 66378506 4 + 1.222 0.873 -1.274
ENSG00000144741 E048 45.9979051 0.0188032778 7.160076e-08 7.476052e-07 3 66378507 66379583 1077 + 1.902 1.447 -1.545
ENSG00000144741 E049 12.9206724 0.0417413543 1.975455e-03 7.150387e-03 3 66379584 66380116 533 + 1.351 0.948 -1.447
ENSG00000144741 E050 15.9823325 0.0104551503 4.534055e-07 4.044083e-06 3 66380117 66380953 837 + 1.477 0.983 -1.750
ENSG00000144741 E051 44.4134134 0.0011015624 1.031986e-10 1.817146e-09 3 66381497 66383750 2254 + 1.830 1.462 -1.254
ENSG00000144741 E052 8.0769735 0.0021280151 3.566387e-14 1.081199e-12 3 66386184 66388116 1933 + 1.373 0.528 -3.251
ENSG00000144741 E053 1.1480412 0.0401232065 1.227487e-02 3.419307e-02 3 66392301 66392545 245 + 0.591 0.136 -2.984