ENSG00000144730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296318 ENSG00000144730 HEK293_OSMI2_2hA HEK293_TMG_2hB IL17RD protein_coding protein_coding 1.615067 1.052747 1.719854 0.07677192 0.1128435 0.7028517 1.3272531 0.7797577 1.47780091 0.04727750 0.05849868 0.9136994 0.8165917 0.7433000 0.86293333 0.1196333 0.26300582 0.01347724 FALSE TRUE
ENST00000498471 ENSG00000144730 HEK293_OSMI2_2hA HEK293_TMG_2hB IL17RD protein_coding processed_transcript 1.615067 1.052747 1.719854 0.07677192 0.1128435 0.7028517 0.1816119 0.2541349 0.08240715 0.05662144 0.04787737 -1.5151987 0.1278583 0.2381333 0.04483333 -0.1933000 0.01347724 0.01347724   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144730 E001 144.5933454 0.0173393885 0.0005783273 0.002453638 3 57089982 57094249 4268 - 2.062 2.266 0.681
ENSG00000144730 E002 21.3672784 0.0009560801 0.5479859902 0.677908944 3 57094250 57094649 400 - 1.328 1.340 0.042
ENSG00000144730 E003 47.9260069 0.0006195404 0.1658507025 0.282802452 3 57094650 57096177 1528 - 1.681 1.672 -0.032
ENSG00000144730 E004 16.0486008 0.0015202346 0.7121430717 0.808981871 3 57096178 57096500 323 - 1.212 1.237 0.089
ENSG00000144730 E005 3.5095967 0.0220129698 0.1463963062 0.256778877 3 57096501 57096505 5 - 0.516 0.787 1.166
ENSG00000144730 E006 0.4375944 0.0263029542 0.2195901952 0.349888590 3 57097473 57097590 118 - 0.226 0.000 -10.841
ENSG00000144730 E007 0.0000000       3 57097591 57097595 5 -      
ENSG00000144730 E008 25.7074607 0.0215733554 0.0566024148 0.120760710 3 57097596 57098538 943 - 1.456 1.331 -0.432
ENSG00000144730 E009 6.9426123 0.0497251354 0.1390722656 0.246797902 3 57101179 57101363 185 - 0.953 0.752 -0.776
ENSG00000144730 E010 4.1184808 0.0374417287 0.0319787852 0.075818596 3 57102479 57102589 111 - 0.795 0.456 -1.494
ENSG00000144730 E011 4.3709331 0.0536636103 0.1339985567 0.239710905 3 57103091 57103145 55 - 0.795 0.576 -0.920
ENSG00000144730 E012 6.6752442 0.0024770595 0.6302054581 0.745412809 3 57104342 57104407 66 - 0.882 0.875 -0.025
ENSG00000144730 E013 9.4131875 0.0019596461 0.3252571766 0.468688885 3 57105857 57105951 95 - 1.024 0.971 -0.197
ENSG00000144730 E014 7.9897662 0.0034175461 0.0581496339 0.123455153 3 57105952 57106008 57 - 0.995 0.818 -0.674
ENSG00000144730 E015 6.2867804 0.0418491151 0.1456618959 0.255748000 3 57106110 57106154 45 - 0.906 0.717 -0.744
ENSG00000144730 E016 7.4765396 0.0028575267 0.0234827100 0.058744787 3 57109537 57109657 121 - 0.985 0.752 -0.899
ENSG00000144730 E017 6.3379630 0.0035484485 0.0169324752 0.044784255 3 57110193 57110311 119 - 0.942 0.673 -1.062
ENSG00000144730 E018 4.4524155 0.0049351378 0.3370632435 0.480923807 3 57114692 57114740 49 - 0.763 0.673 -0.367
ENSG00000144730 E019 4.8617956 0.0384166723 0.3883424111 0.532435036 3 57114741 57114817 77 - 0.795 0.711 -0.339
ENSG00000144730 E020 2.5022252 0.7542235977 0.6767728660 0.781645862 3 57120256 57120313 58 - 0.571 0.492 -0.370
ENSG00000144730 E021 0.0000000       3 57142453 57142491 39 -      
ENSG00000144730 E022 4.6842743 0.0036931889 0.0007308469 0.003010060 3 57150290 57150496 207 - 0.485 0.992 2.103
ENSG00000144730 E023 0.1515154 0.0434476132 0.8576361442   3 57164926 57165160 235 - 0.089 0.000 -9.258
ENSG00000144730 E024 3.0601125 0.1159217337 0.6733247096 0.779045464 3 57165161 57165375 215 - 0.622 0.574 -0.215
ENSG00000144730 E025 1.2941444 0.0103701775 0.9324284097 0.961431677 3 57169232 57169394 163 - 0.330 0.379 0.289
ENSG00000144730 E026 0.6664265 0.0166167287 0.5715865160 0.697835408 3 57170233 57170306 74 - 0.163 0.285 1.026