ENSG00000144711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273221 ENSG00000144711 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC1 protein_coding protein_coding 17.50879 19.18449 20.00065 1.785917 0.2336879 0.06007639 2.246487 3.4104006 3.2825253 0.35745383 0.3995586 -0.0549708 0.12107083 0.1782000 0.16380000 -0.01440000 8.447869e-01 2.466445e-18 FALSE TRUE
ENST00000613206 ENSG00000144711 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC1 protein_coding protein_coding 17.50879 19.18449 20.00065 1.785917 0.2336879 0.06007639 4.135034 7.5248801 0.9601438 0.96583813 0.5606286 -2.9573140 0.24349583 0.4001667 0.04803333 -0.35213333 8.724152e-02 2.466445e-18 FALSE TRUE
MSTRG.22497.4 ENSG00000144711 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC1 protein_coding   17.50879 19.18449 20.00065 1.785917 0.2336879 0.06007639 8.378717 6.4464078 11.4685008 1.52287128 0.3740564 0.8301306 0.48187500 0.3273000 0.57396667 0.24666667 8.220807e-03 2.466445e-18 FALSE TRUE
MSTRG.22497.5 ENSG00000144711 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC1 protein_coding   17.50879 19.18449 20.00065 1.785917 0.2336879 0.06007639 1.004034 0.0000000 2.2126653 0.00000000 0.3270897 7.7961469 0.05892083 0.0000000 0.11043333 0.11043333 2.466445e-18 2.466445e-18 FALSE TRUE
MSTRG.22497.7 ENSG00000144711 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC1 protein_coding   17.50879 19.18449 20.00065 1.785917 0.2336879 0.06007639 0.732158 0.2368383 1.4394276 0.02516787 0.1392107 2.5538450 0.03997500 0.0123000 0.07186667 0.05956667 3.298770e-09 2.466445e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144711 E001 0.6266857 0.0168535106 9.813876e-01 9.923987e-01 3 12897043 12897219 177 - 0.209 0.227 0.151
ENSG00000144711 E002 171.4800810 0.0168482899 1.040671e-13 2.951376e-12 3 12897220 12897574 355 - 1.840 2.426 1.961
ENSG00000144711 E003 631.3238738 0.0071013136 1.347007e-15 5.011516e-14 3 12897575 12898392 818 - 2.562 2.942 1.267
ENSG00000144711 E004 846.7797611 0.0015645063 8.051660e-29 1.223226e-26 3 12898393 12899434 1042 - 2.753 3.040 0.952
ENSG00000144711 E005 625.0829230 0.0015301058 5.844357e-04 2.476117e-03 3 12899435 12900326 892 - 2.718 2.853 0.449
ENSG00000144711 E006 141.3486602 0.0019314725 3.789049e-01 5.231953e-01 3 12900327 12900569 243 - 2.137 2.163 0.086
ENSG00000144711 E007 70.7804033 0.0003544595 6.024824e-01 7.234435e-01 3 12900570 12900576 7 - 1.832 1.866 0.113
ENSG00000144711 E008 167.8130129 0.0002658548 4.114983e-02 9.316099e-02 3 12900577 12900752 176 - 2.220 2.220 -0.002
ENSG00000144711 E009 265.6864021 0.0003820561 2.718061e-03 9.426780e-03 3 12900753 12901522 770 - 2.427 2.415 -0.039
ENSG00000144711 E010 25.2112257 0.0020264849 4.501713e-01 5.913151e-01 3 12902773 12902822 50 - 1.410 1.411 0.003
ENSG00000144711 E011 118.1803745 0.0034524017 2.606967e-03 9.085226e-03 3 12908349 12908525 177 - 2.110 2.039 -0.236
ENSG00000144711 E012 144.2575186 0.0053174728 1.256015e-04 6.393879e-04 3 12909273 12909434 162 - 2.215 2.102 -0.378
ENSG00000144711 E013 104.4524345 0.0038336661 2.124590e-06 1.642913e-05 3 12911629 12911728 100 - 2.094 1.938 -0.524
ENSG00000144711 E014 71.0834994 0.0006227826 2.500616e-05 1.516289e-04 3 12913428 12913458 31 - 1.913 1.788 -0.420
ENSG00000144711 E015 116.6418954 0.0043984973 1.144457e-03 4.452414e-03 3 12913459 12913553 95 - 2.109 2.022 -0.292
ENSG00000144711 E016 66.8605377 0.0025956141 6.057710e-03 1.876200e-02 3 12915104 12915133 30 - 1.863 1.785 -0.261
ENSG00000144711 E017 173.5881299 0.0020897443 6.073245e-11 1.109185e-09 3 12915594 12915733 140 - 2.315 2.149 -0.554
ENSG00000144711 E018 189.2155651 0.0002880301 1.122052e-27 1.544836e-25 3 12920430 12920596 167 - 2.382 2.148 -0.779
ENSG00000144711 E019 132.3191225 0.0002527977 3.416273e-20 2.228659e-18 3 12922120 12922242 123 - 2.227 1.995 -0.777
ENSG00000144711 E020 132.3008651 0.0052584041 8.470504e-07 7.146486e-06 3 12924581 12924742 162 - 2.203 2.034 -0.566
ENSG00000144711 E021 406.2099867 0.0108714145 1.105490e-06 9.093890e-06 3 12935448 12936550 1103 - 2.691 2.515 -0.586
ENSG00000144711 E022 82.0424728 0.0038335279 2.966658e-11 5.718023e-10 3 12936551 12936697 147 - 2.035 1.765 -0.907
ENSG00000144711 E023 116.8958491 0.0039262760 1.305791e-14 4.226521e-13 3 12941571 12941865 295 - 2.194 1.908 -0.959
ENSG00000144711 E024 1.7724325 0.0079839822 8.097994e-03 2.402877e-02 3 12960277 12960638 362 - 0.117 0.612 3.322
ENSG00000144711 E025 11.3191979 0.0015582129 3.024396e-04 1.389506e-03 3 12963198 12963327 130 - 0.817 1.242 1.568
ENSG00000144711 E026 42.3324969 0.0299138100 2.377564e-03 8.391346e-03 3 12967387 12967713 327 - 1.738 1.508 -0.781
ENSG00000144711 E027 0.1817044 0.0396176627 4.977738e-01   3 12986971 12987036 66 - 0.000 0.128 8.848
ENSG00000144711 E028 0.4386386 0.1893891225 6.060348e-01 7.263056e-01 3 12994081 12994384 304 - 0.208 0.127 -0.860
ENSG00000144711 E029 0.0000000       3 12995024 12995126 103 -      
ENSG00000144711 E030 0.5244761 0.2515708923 6.242735e-01 7.406485e-01 3 13022033 13022596 564 - 0.209 0.130 -0.828
ENSG00000144711 E031 0.0000000       3 13042287 13042440 154 -      
ENSG00000144711 E032 12.3833945 0.0013855341 2.495402e-03 8.750350e-03 3 13047478 13047522 45 - 1.232 0.997 -0.847
ENSG00000144711 E033 0.0000000       3 13072992 13073429 438 -      
ENSG00000144711 E034 11.0062101 0.0128586552 2.217496e-03 7.897913e-03 3 13164104 13164133 30 - 1.208 0.914 -1.070
ENSG00000144711 E035 15.2221591 0.0106107428 2.512951e-07 2.362987e-06 3 13282711 13283281 571 - 1.394 0.915 -1.720