ENSG00000144674

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356847 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding protein_coding 12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 2.15396734 0.3142670 3.6233124 0.06345653 0.2750981 3.4860312 0.13882500 0.06916667 0.20946667 0.14030000 1.668519e-04 4.094695e-23 FALSE TRUE
ENST00000361924 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding protein_coding 12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 1.70570253 1.7342068 1.0818637 0.31764081 0.5527506 -0.6757783 0.21732500 0.37670000 0.06140000 -0.31530000 1.594539e-01 4.094695e-23 FALSE TRUE
ENST00000437131 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding protein_coding 12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 3.81159065 2.1668678 3.7795886 0.42966189 0.4567917 0.7997874 0.33910833 0.46830000 0.21760000 -0.25070000 1.534074e-03 4.094695e-23 FALSE TRUE
ENST00000444882 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding protein_coding 12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 0.09197987 0.2676938 0.0000000 0.26769381 0.0000000 -4.7954231 0.02166667 0.07516667 0.00000000 -0.07516667 5.883525e-01 4.094695e-23 FALSE TRUE
MSTRG.22710.10 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding   12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 3.90393745 0.0000000 6.7562346 0.00000000 0.4751241 9.4022094 0.20321667 0.00000000 0.39103333 0.39103333 4.094695e-23 4.094695e-23 TRUE TRUE
MSTRG.22710.13 ENSG00000144674 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA4 protein_coding   12.93473 4.525532 17.32818 0.4869912 0.3041272 1.934609 0.47871867 0.0000000 0.9135962 0.00000000 0.3357579 6.5291903 0.03165000 0.00000000 0.05343333 0.05343333 1.927172e-03 4.094695e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144674 E001 0.0000000       3 37240855 37241494 640 +      
ENSG00000144674 E002 0.0000000       3 37241495 37241825 331 +      
ENSG00000144674 E003 0.0000000       3 37241826 37241887 62 +      
ENSG00000144674 E004 0.0000000       3 37241888 37241920 33 +      
ENSG00000144674 E005 0.1451727 0.0433223988 1.000000e+00   3 37241921 37243190 1270 + 0.072 0.000 -8.087
ENSG00000144674 E006 1.1718769 0.0549110075 8.946970e-02 1.743229e-01 3 37243191 37243246 56 + 0.389 0.000 -12.928
ENSG00000144674 E007 1.1718769 0.0549110075 8.946970e-02 1.743229e-01 3 37243247 37243251 5 + 0.389 0.000 -12.928
ENSG00000144674 E008 1.3191260 0.0263054192 6.026798e-02 1.270668e-01 3 37243252 37243269 18 + 0.420 0.000 -13.381
ENSG00000144674 E009 1.6158141 0.0146480628 3.150231e-02 7.488479e-02 3 37243270 37243270 1 + 0.476 0.000 -13.821
ENSG00000144674 E010 11.3658911 0.0015197318 5.004700e-03 1.594265e-02 3 37243271 37243337 67 + 1.119 0.753 -1.381
ENSG00000144674 E011 21.8509928 0.0008624685 8.063727e-06 5.470542e-05 3 37243338 37243423 86 + 1.394 0.934 -1.648
ENSG00000144674 E012 36.8405349 0.0006039520 2.269927e-09 3.150179e-08 3 37243424 37243622 199 + 1.616 1.123 -1.716
ENSG00000144674 E013 0.4427912 0.2579705837 6.756062e-01 7.808204e-01 3 37245303 37245421 119 + 0.134 0.197 0.666
ENSG00000144674 E014 1.0382438 0.0121668039 5.547580e-01 6.837016e-01 3 37249701 37250607 907 + 0.320 0.200 -0.901
ENSG00000144674 E015 29.3202196 0.0008361691 1.405222e-05 9.019962e-05 3 37251395 37251467 73 + 1.503 1.123 -1.331
ENSG00000144674 E016 22.9087873 0.0008222080 2.120350e-04 1.015404e-03 3 37251468 37251484 17 + 1.397 1.038 -1.271
ENSG00000144674 E017 0.8921407 0.0132526883 1.513887e-01 2.635582e-01 3 37266842 37266940 99 + 0.320 0.000 -13.027
ENSG00000144674 E018 26.2539412 0.0007809631 4.106809e-07 3.695449e-06 3 37273536 37273601 66 + 1.475 0.989 -1.721
ENSG00000144674 E019 50.0443909 0.0004465190 1.355073e-12 3.248728e-11 3 37281958 37282091 134 + 1.748 1.239 -1.750
ENSG00000144674 E020 48.0319230 0.0004906921 1.282110e-12 3.089048e-11 3 37282092 37282182 91 + 1.732 1.209 -1.804
ENSG00000144674 E021 53.6674850 0.0004275939 2.514092e-16 1.030702e-14 3 37282183 37282272 90 + 1.786 1.193 -2.041
ENSG00000144674 E022 31.8367217 0.0012053063 8.010104e-09 1.005384e-07 3 37286014 37286061 48 + 1.559 1.038 -1.827
ENSG00000144674 E023 0.3729606 0.0286074436 3.873264e-01 5.314692e-01 3 37287527 37287612 86 + 0.072 0.200 1.688
ENSG00000144674 E024 36.1857341 0.0080654388 1.529255e-08 1.821177e-07 3 37289235 37289291 57 + 1.615 1.062 -1.934
ENSG00000144674 E025 21.6407945 0.0113913978 1.074928e-05 7.091584e-05 3 37294979 37294981 3 + 1.400 0.871 -1.908
ENSG00000144674 E026 44.7147433 0.0020296629 1.126087e-10 1.970751e-09 3 37294982 37295077 96 + 1.700 1.193 -1.752
ENSG00000144674 E027 59.8448445 0.0049191100 3.116120e-12 7.058945e-11 3 37296087 37296219 133 + 1.825 1.295 -1.814
ENSG00000144674 E028 71.3406501 0.0003555217 2.422042e-21 1.809340e-19 3 37298833 37299020 188 + 1.908 1.307 -2.052
ENSG00000144674 E029 47.8253041 0.0028276859 2.619349e-12 6.009055e-11 3 37299288 37299371 84 + 1.735 1.176 -1.929
ENSG00000144674 E030 61.1943410 0.0023258857 4.305518e-15 1.494992e-13 3 37302185 37302332 148 + 1.839 1.281 -1.910
ENSG00000144674 E031 0.4847352 0.2301019593 6.888509e-01 7.908993e-01 3 37313422 37313519 98 + 0.135 0.200 0.685
ENSG00000144674 E032 65.2565308 0.0003654412 2.661742e-16 1.088407e-14 3 37315420 37315598 179 + 1.863 1.343 -1.774
ENSG00000144674 E033 0.2924217 0.0272158035 7.986483e-01   3 37315865 37315929 65 + 0.134 0.000 -11.270
ENSG00000144674 E034 59.7643588 0.0004542141 1.217235e-16 5.176239e-15 3 37319063 37319194 132 + 1.829 1.267 -1.923
ENSG00000144674 E035 1.7014481 0.0128759756 3.416879e-01 4.856094e-01 3 37319195 37320382 1188 + 0.356 0.523 0.876
ENSG00000144674 E036 0.0000000       3 37321589 37321730 142 +      
ENSG00000144674 E037 64.9930972 0.0125530710 1.579905e-11 3.183454e-10 3 37321731 37321886 156 + 1.868 1.270 -2.045
ENSG00000144674 E038 990.4438109 0.0025745217 2.871045e-06 2.157263e-05 3 37323588 37327636 4049 + 2.969 2.872 -0.320
ENSG00000144674 E039 119.2609414 0.0002989819 4.846560e-05 2.740059e-04 3 37327637 37327764 128 + 1.981 2.118 0.460
ENSG00000144674 E040 83.9024756 0.0003593785 2.472938e-03 8.682505e-03 3 37327765 37327825 61 + 1.835 1.956 0.409
ENSG00000144674 E041 117.1167967 0.0004005007 1.566805e-04 7.769311e-04 3 37328416 37328537 122 + 1.979 2.108 0.432
ENSG00000144674 E042 125.2406517 0.0002996291 3.417585e-08 3.807355e-07 3 37328963 37329093 131 + 1.988 2.169 0.608
ENSG00000144674 E043 0.3332198 0.0294714732 3.877019e-01   3 37329094 37329339 246 + 0.072 0.200 1.685
ENSG00000144674 E044 128.9384407 0.0002797920 9.926146e-16 3.747466e-14 3 37335053 37335166 114 + 1.970 2.229 0.865
ENSG00000144674 E045 60.3364125 0.0004128805 1.033776e-07 1.047192e-06 3 37337143 37337163 21 + 1.651 1.899 0.839
ENSG00000144674 E046 98.5455339 0.0002906221 1.400966e-13 3.897913e-12 3 37337666 37337734 69 + 1.852 2.122 0.907
ENSG00000144674 E047 95.3036252 0.0008494441 2.309380e-14 7.200544e-13 3 37340124 37340199 76 + 1.825 2.121 0.992
ENSG00000144674 E048 101.3223019 0.0003247415 2.120270e-18 1.121694e-16 3 37347193 37347296 104 + 1.846 2.160 1.055
ENSG00000144674 E049 109.5061475 0.0003273079 1.169444e-18 6.403111e-17 3 37355101 37355187 87 + 1.882 2.188 1.026
ENSG00000144674 E050 58.4378665 0.0087610031 1.037284e-05 6.870271e-05 3 37361243 37361305 63 + 1.624 1.906 0.953
ENSG00000144674 E051 154.4994289 0.0029004949 1.330948e-17 6.433887e-16 3 37366080 37366272 193 + 2.024 2.345 1.071
ENSG00000144674 E052 128.8913488 0.0160144561 9.271581e-15 3.064329e-13 3 37366273 37366879 607 + 1.853 2.369 1.731
ENSG00000144674 E053 0.1515154 0.0431839103 1.000000e+00   3 37379042 37379087 46 + 0.072 0.000 -10.092