ENSG00000144635

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273130 ENSG00000144635 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1LI1 protein_coding protein_coding 34.54183 22.01461 54.3633 2.662811 1.673809 1.303782 27.219900 13.754780 44.264741 1.201387 0.7503295 1.6855023 0.7519750 0.6304333 0.8166000 0.1861667 0.02941934 0.02941934 FALSE TRUE
MSTRG.22672.5 ENSG00000144635 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1LI1 protein_coding   34.54183 22.01461 54.3633 2.662811 1.673809 1.303782 6.148992 7.779103 8.518138 1.535793 2.9244513 0.1307737 0.2156292 0.3482333 0.1538333 -0.1944000 0.04397629 0.02941934 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144635 E001 11.1602950 0.0015148913 6.366732e-03 1.957541e-02 3 32525974 32526099 126 - 0.950 1.228 1.009
ENSG00000144635 E002 79.1350049 0.0079559795 2.252502e-01 3.567288e-01 3 32526100 32526283 184 - 1.914 1.845 -0.233
ENSG00000144635 E003 136.3426983 0.0003279590 5.374637e-03 1.694755e-02 3 32526284 32526620 337 - 2.153 2.072 -0.272
ENSG00000144635 E004 340.1914539 0.0024761863 5.708197e-02 1.216082e-01 3 32526621 32526908 288 - 2.494 2.564 0.232
ENSG00000144635 E005 400.1677554 0.0031309361 2.704704e-07 2.525124e-06 3 32528446 32528601 156 - 2.520 2.693 0.578
ENSG00000144635 E006 320.5379429 0.0035042549 4.735469e-03 1.519256e-02 3 32529540 32529629 90 - 2.453 2.561 0.360
ENSG00000144635 E007 233.1629058 0.0046431295 6.899355e-02 1.417054e-01 3 32529630 32529660 31 - 2.324 2.413 0.298
ENSG00000144635 E008 252.5789803 0.0060430524 1.059384e-01 1.995260e-01 3 32530284 32530328 45 - 2.359 2.445 0.288
ENSG00000144635 E009 2.0141431 0.2948377910 8.911368e-01 9.344656e-01 3 32530329 32530460 132 - 0.450 0.468 0.092
ENSG00000144635 E010 272.1588307 0.0077347074 1.233306e-01 2.247158e-01 3 32530461 32530520 60 - 2.389 2.479 0.302
ENSG00000144635 E011 10.6228708 0.0147604522 2.097975e-02 5.354588e-02 3 32530521 32532985 2465 - 1.136 0.851 -1.057
ENSG00000144635 E012 354.0773225 0.0001933757 1.572378e-04 7.794497e-04 3 32532986 32533097 112 - 2.507 2.590 0.279
ENSG00000144635 E013 348.3559593 0.0012462466 5.484337e-02 1.177274e-01 3 32534511 32534646 136 - 2.510 2.562 0.173
ENSG00000144635 E014 321.6949891 0.0002942931 2.113305e-01 3.400668e-01 3 32537011 32537104 94 - 2.502 2.484 -0.061
ENSG00000144635 E015 0.5954526 0.0184340418 1.572991e-01 2.715124e-01 3 32537105 32537272 168 - 0.280 0.000 -11.935
ENSG00000144635 E016 184.4723326 0.0002128253 3.160923e-02 7.509330e-02 3 32541037 32541051 15 - 2.273 2.223 -0.166
ENSG00000144635 E017 423.3069108 0.0018447947 5.113270e-02 1.111895e-01 3 32541052 32541206 155 - 2.632 2.582 -0.166
ENSG00000144635 E018 396.5502223 0.0006542871 1.774535e-03 6.518281e-03 3 32544876 32544988 113 - 2.608 2.546 -0.205
ENSG00000144635 E019 367.9494244 0.0009245375 1.496132e-04 7.453198e-04 3 32544989 32545106 118 - 2.582 2.497 -0.283
ENSG00000144635 E020 0.8878743 0.0131346723 5.856639e-02 1.241721e-01 3 32545427 32545848 422 - 0.372 0.000 -12.520
ENSG00000144635 E021 199.6083289 0.0051397733 1.449847e-01 2.548140e-01 3 32545849 32545873 25 - 2.309 2.248 -0.203
ENSG00000144635 E022 293.5521008 0.0044973878 1.074761e-02 3.056156e-02 3 32545874 32545965 92 - 2.488 2.389 -0.330
ENSG00000144635 E023 0.7760110 0.0165327447 7.501419e-01 8.369088e-01 3 32566613 32566735 123 - 0.225 0.287 0.465
ENSG00000144635 E024 1.1804097 0.1910922690 5.753062e-02 1.223837e-01 3 32570141 32570345 205 - 0.448 0.000 -12.934
ENSG00000144635 E025 201.4991326 0.0028511120 4.771563e-04 2.072538e-03 3 32570346 32570419 74 - 2.334 2.208 -0.423
ENSG00000144635 E026 1.5521227 0.0094034605 6.559748e-01 7.657478e-01 3 32570420 32570624 205 - 0.372 0.458 0.465
ENSG00000144635 E027 292.9716547 0.0078977589 4.085910e-04 1.807419e-03 3 32570625 32570858 234 - 2.509 2.335 -0.581